Cytochrome P450 and P‐Glycoprotein‐Mediated Interactions Involving African Herbs Indicated for Common Noncommunicable Diseases

Evidence-based Complementary and Alternative Medicine - Tập 2017 Số 1 - 2017
Gregory Ondieki1, Makafui Nyagblordzro1, Siambi Kikete1, Rongjia Liang1, Lili Wang1,2, Xin He1,2
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin 300193, China
2Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China

Tóm tắt

Herbal remedies are regularly used to complement conventional therapies in the treatment of various illnesses in Africa. This may be because they are relatively cheap and easily accessible and are believed by many to be safe, cause fewer side effects, and are less likely to cause dependency. On the contrary, many herbs have been shown to alter the pharmacokinetics of coadministered allopathic medicines and can either synergize or antagonize therapeutic effects as well as altering the toxicity profiles of these drugs. Current disease burden data point towards epidemiological transitions characterised by increasing urbanization and changing lifestyles, risk factors for chronic diseases like hypertension, diabetes, and cancer which often present as multimorbidities. As a result, we highlight African herb‐drug interactions (HDIs) modulated via cytochrome P450 enzyme family (CYP) and P‐glycoprotein (P‐gp) and the consequences thereof in relation to antihypertensive, antidiabetic, and anticancer drugs. CYPs are enzymes which account for to up to 70% of drug metabolism while P‐gp is an efflux pump that extrudes drug substrates out of cells. Consequently, regulation of the relative activity of both CYP and P‐gp by African herbs influences the effective drug concentration at the site of action and modifies therapeutic outcomes.

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