Hiểu biết hiện tại về chẩn đoán và điều trị bệnh Alzheimer

F1000Research - Tập 7 - Trang 1161
Jason Weller1,2, Andrew E. Budson1,2
1Department of Neurology, Boston University School of Medicine, 72 East Concord Street C-309, Boston, MA, USA
2Department of Neurology, Boston VA Hospital, 150 South Huntington Street, Jamaica Plain, MA, 02130, USA

Tóm tắt

Bệnh Alzheimer là nguyên nhân phổ biến nhất gây ra chứng mất trí nhớ trên toàn thế giới, với tỷ lệ mắc bệnh tiếp tục gia tăng một phần do dân số thế giới đang già đi. Quá trình bệnh lý thoái hóa thần kinh này được đặc trưng theo cách cổ điển bởi hai bệnh lý điển hình: sự lắng đọng của mảng β-amyloid và các đám rối sợi thần kinh của tau phosphoryl hóa quá mức. Chẩn đoán dựa trên việc xuất hiện lâm sàng thỏa mãn một số tiêu chí cũng như các dấu hiệu sinh học từ dịch cơ thể và hình ảnh. Hiện tại, điều trị chủ yếu tập trung vào liệu pháp triệu chứng, mặc dù có các thử nghiệm đang diễn ra với mục tiêu giảm sản xuất và tổng thể gánh nặng của bệnh lý trong não. Tại đây, chúng tôi thảo luận về những tiến bộ gần đây trong việc hiểu biết về đánh giá lâm sàng và điều trị bệnh Alzheimer, cùng với các cập nhật về các thử nghiệm lâm sàng vẫn đang tiếp tục.

Từ khóa

#bệnh Alzheimer #chứng mất trí nhớ #bệnh lý thần kinh #chẩn đoán #điều trị #nghiên cứu lâm sàng

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