Current insights into the role of human β-defensins in atopic dermatitis

Nutten, 2015, Atopic dermatitis: global epidemiology and risk factors, Ann Nutr Metab, 66(Suppl.1), 8, 10.1159/000370220

Lee, 2006, An update of the defensive barrier function of skin, Yonsei Med J, 47, 293, 10.3349/ymj.2006.47.3.293

Niyonsaba, 2009, Multifunctional antimicrobial proteins and peptides: natural activators of immune systems, Curr Pharm Des, 15, 2393, 10.2174/138161209788682271

Niyonsaba, 2016, The role of human beta-defensins in allergic diseases, Clin Exp Allergy, 46, 1522, 10.1111/cea.12843

Pazgier, 2006, Human beta-defensins, Cell Mol Life Sci, 63, 1294, 10.1007/s00018-005-5540-2

Niyonsaba, 2017, Friends or foes? Host defense (antimicrobial) peptides and proteins in human skin diseases, Exp Dermatol, 10.1111/exd.13314

Hata, 2010, History of eczema herpeticum is associated with the inability to induce human beta-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis, Br J Dermatol, 163, 659, 10.1111/j.1365-2133.2010.09892.x

Nomura, 2003, Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes, J Immunol, 171, 3262, 10.4049/jimmunol.171.6.3262

Bensch, 1995, hBD-1: a novel beta-defensin from human plasma, FEBS Lett, 368, 331, 10.1016/0014-5793(95)00687-5

Ali, 2001, Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin, J Invest Dermatol, 117, 106, 10.1046/j.0022-202x.2001.01401.x

Harder, 1997, A peptide antibiotic from human skin, Nature, 387, 861, 10.1038/43088

Wolk, 2004, IL-22 increases the innate immunity of tissues, Immunity, 21, 241, 10.1016/j.immuni.2004.07.007

Kao, 2004, IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways, J Immunol, 173, 3482, 10.4049/jimmunol.173.5.3482

Wilson, 2007, Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat Immunol, 8, 950, 10.1038/ni1497

Liu, 2002, Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation, J Invest Dermatol, 118, 275, 10.1046/j.0022-202x.2001.01651.x

Oren, 2003, In human epidermis, beta-defensin 2 is packaged in lamellar bodies, Exp Mol Pathol, 74, 180, 10.1016/S0014-4800(02)00023-0

Duits, 2002, Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells, Immunology, 106, 517, 10.1046/j.1365-2567.2002.01430.x

Harder, 2001, Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic, J Biol Chem, 276, 5707, 10.1074/jbc.M008557200

Sawamura, 2005, Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection, Gene Ther, 12, 857, 10.1038/sj.gt.3302472

Garcia, 2001, Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity, FASEB J, 15, 1819, 10.1096/fj.00-0865fje

Harder, 2004, Differential gene induction of human beta-defensins (hBD-1, −2, −3, and −4) in keratinocytes is inhibited by retinoic acid, J Invest Dermatol, 123, 522, 10.1111/j.0022-202X.2004.23234.x

Rivas-Santiago, 2009, Susceptibility to infectious diseases based on antimicrobial peptide production, Infect Immun, 77, 4690, 10.1128/IAI.01515-08

Garcia, 2001, Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction, Cell Tissue Res, 306, 257, 10.1007/s004410100433

MacLeod, 2016, The innate immune system in acute and chronic wounds, Adv Wound Care (New Rochelle), 5, 65, 10.1089/wound.2014.0608

Niyonsaba, 2007, Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines, J Invest Dermatol, 127, 594, 10.1038/sj.jid.5700599

Kiatsurayanon, 2014, Host defense (antimicrobial) peptide, human beta-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes, J Invest Dermatol, 134, 2163, 10.1038/jid.2014.143

Lai, 2010, Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections, J Invest Dermatol, 130, 2211, 10.1038/jid.2010.123

Ommori, 2013, Selective induction of antimicrobial peptides from keratinocytes by staphylococcal bacteria, Microb Pathog, 56, 35, 10.1016/j.micpath.2012.11.005

Christophers, 1987, Contrasting disease patterns in psoriasis and atopic dermatitis, Arch Dermatol Res, 279, S48, 10.1007/BF00585919

Ong, 2002, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N Engl J Med, 347, 1151, 10.1056/NEJMoa021481

Brandt, 2011, Th2 cytokines and atopic dermatitis, J Clin Cell Immunol, 2, 110, 10.4172/2155-9899.1000110

da Silva, 2014, Mast cell function: a new vision of an old cell, J Histochem Cytochem, 62, 698, 10.1369/0022155414545334

Kabashima, 2013, New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity, J Dermatol Sci, 70, 3, 10.1016/j.jdermsci.2013.02.001

Albanesi, 2007, IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3, J Immunol, 179, 984, 10.4049/jimmunol.179.2.984

Howell, 2005, Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis, J Invest Dermatol, 125, 738, 10.1111/j.0022-202X.2005.23776.x

Cornelissen, 2012, IL-31 regulates differentiation and filaggrin expression in human organotypic skin models, J Allergy Clin Immunol, 129, 426, 10.1016/j.jaci.2011.10.042

Howell, 2008, Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation, J Invest Dermatol, 128, 2248, 10.1038/jid.2008.74

Honzke, 2016, Influence of Th2 cytokines on the cornified envelope, tight junction proteins, and beta-defensins in filaggrin-deficient skin equivalents, J Invest Dermatol, 136, 631, 10.1016/j.jid.2015.11.007

van Drongelen, 2014, Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models, Clin Exp Allergy, 44, 1515, 10.1111/cea.12443

Hamid, 1994, Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis, J Clin Invest, 94, 870, 10.1172/JCI117408

Harder, 2010, Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury, J Invest Dermatol, 130, 1355, 10.1038/jid.2009.432

Koga, 2008, Possible pathogenic role of Th17 cells for atopic dermatitis, J Invest Dermatol, 128, 2625, 10.1038/jid.2008.111

Toda, 2003, Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions, J Allergy Clin Immunol, 111, 875, 10.1067/mai.2003.1414

Nakajima, 2014, IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models, J Invest Dermatol, 134, 2122, 10.1038/jid.2014.51

Oyoshi, 2009, Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen, J Allergy Clin Immunol, 124, 485, 10.1016/j.jaci.2009.05.042

Kanda, 2012, Increased serum human beta-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M, Immunobiology, 217, 436, 10.1016/j.imbio.2011.10.010

Borkowski, 2011, The coordinated response of the physical and antimicrobial peptide barriers of the skin, J Invest Dermatol, 131, 285, 10.1038/jid.2010.360

Aberg, 2008, Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers, J Invest Dermatol, 128, 917, 10.1038/sj.jid.5701099

Sorensen, 2006, Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor, J Clin Invest, 116, 1878, 10.1172/JCI28422

Gambichler, 2006, Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy, Br J Dermatol, 155, 1275, 10.1111/j.1365-2133.2006.07481.x

Brown, 2012, One remarkable molecule: filaggrin, J Invest Dermatol, 132, 751, 10.1038/jid.2011.393

Scharschmidt, 2009, Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens, J Allergy Clin Immunol, 124, 496, 10.1016/j.jaci.2009.06.046

Elias, 2014, Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis, J Allergy Clin Immunol, 134, 781, 10.1016/j.jaci.2014.05.048

Clausen, 2013, Human beta-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis, Br J Dermatol, 169, 587, 10.1111/bjd.12419

Jensen, 2004, Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis, J Invest Dermatol, 122, 1423, 10.1111/j.0022-202X.2004.22621.x

Suarez-Farinas, 2011, Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities, J Allergy Clin Immunol, 127, 954, 10.1016/j.jaci.2010.12.1124

de Koning, 2011, Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients, J Invest Dermatol, 131, 263, 10.1038/jid.2010.278

Buddenkotte, 2010, Pathophysiology and therapy of pruritus in allergic and atopic diseases, Allergy, 65, 805, 10.1111/j.1398-9995.2010.01995.x

Valdman-Grinshpoun, 2012, Barrier-restoring therapies in atopic dermatitis: current approaches and future perspectives, Dermatol Res Pract, 2012, 923134, 10.1155/2012/923134

Sano, 2013, Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis, Clin Exp Immunol, 171, 330, 10.1111/cei.12021

Turner, 2014, A new itch to scratch for TSLP, Trends Immunol, 35, 49, 10.1016/j.it.2013.12.001

Albrecht, 2015, Expression and function of histamine and its receptors in atopic dermatitis, Mol Cell Pediatr, 2, 16, 10.1186/s40348-015-0027-1

Hellstrand, 1995, Role of histamine in natural killer cell-dependent protection against herpes simplex virus type 2 infection in mice, Clin Diagn Lab Immunol, 2, 277, 10.1128/cdli.2.3.277-280.1995

Megyeri, 2006, The role of histamine in the intracellular survival of Mycobacterium bovis BCG, Microbes Infect, 8, 1035, 10.1016/j.micinf.2005.10.022

Ishikawa, 2009, Histamine induces human beta-defensin-3 production in human keratinocytes, J Dermatol Sci, 56, 121, 10.1016/j.jdermsci.2009.07.012

Kanda, 2007, Histamine enhances the production of human beta-defensin-2 in human keratinocytes, Am J Physiol Cell Physiol, 293, C1916, 10.1152/ajpcell.00293.2007

Lee, 2016, TSLP down-regulates S100A7 and beta-defensin 2 via the JAK2/STAT3-dependent mechanism, J Invest Dermatol, 136, 2427, 10.1016/j.jid.2016.07.027

Miller, 2011, Role of IL-33 in inflammation and disease, J Inflamm (Lond), 8, 22, 10.1186/1476-9255-8-22

Alase, 2012, Interleukin-33 modulates the expression of human beta-defensin 2 in human primary keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis, Br J Dermatol, 167, 1386, 10.1111/j.1365-2133.2012.11140.x

Hon, 2013, Acceptability and efficacy of an emollient containing ceramide-precursor lipids and moisturizing factors for atopic dermatitis in pediatric patients, Drugs R D, 13, 37, 10.1007/s40268-013-0004-x

Park, 2010, Changes of antimicrobial peptides and transepidermal water loss after topical application of tacrolimus and ceramide-dominant emollient in patients with atopic dermatitis, J Korean Med Sci, 25, 766, 10.3346/jkms.2010.25.5.766

Grether-Beck, 2012, Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression, J Invest Dermatol, 132, 1561, 10.1038/jid.2012.42

Cury Martins, 2015, Topical tacrolimus for atopic dermatitis, Cochrane Database Syst Rev, CD009864

Chittock, 2015, Comparing the effect of a twice-weekly tacrolimus and betamethasone valerate dose on the subclinical epidermal barrier defect in atopic dermatitis, Acta Derm Venereol, 95, 653, 10.2340/00015555-2048

Hewison, 2010, Vitamin D and the immune system: new perspectives on an old theme, Endocrinol Metab Clin North Am, 39, 365, 10.1016/j.ecl.2010.02.010

Kim, 2016, Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: a systematic review and meta-analysis, Nutrients, 8, E789, 10.3390/nu8120789

Peroni, 2011, Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children, Br J Dermatol, 164, 1078, 10.1111/j.1365-2133.2010.10147.x

Wang, 2014, Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis, Pediatr Allergy Immunol, 25, 30, 10.1111/pai.12167

Matheson, 2010, Vitamin D and methicillin-resistant Staphylococcus aureus nasal carriage, Scand J Infect Dis, 42, 455, 10.3109/00365541003602049

Bikle, 2011, Vitamin D metabolism and function in the skin, Mol Cell Endocrinol, 347, 80, 10.1016/j.mce.2011.05.017

Kim, 2010, Toll-like receptors and antimicrobial peptides expressions of psoriasis: correlation with serum vitamin D level, J Korean Med Sci, 25, 1506, 10.3346/jkms.2010.25.10.1506

Heine, 2013, Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults, Br J Dermatol, 168, 855, 10.1111/bjd.12077

Hartmann, 2012, Vitamin D receptor activation improves allergen-triggered eczema in mice, J Invest Dermatol, 132, 330, 10.1038/jid.2011.296

Wang, 2004, Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression, J Immunol, 173, 2909, 10.4049/jimmunol.173.5.2909

Liu, 2009, Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses, PLoS One, 4, e5810, 10.1371/journal.pone.0005810

Hong, 2008, Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement, J Invest Dermatol, 128, 2880, 10.1038/jid.2008.169

Glaser, 2009, UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo, J Allergy Clin Immunol, 123, 1117, 10.1016/j.jaci.2009.01.043

Ong, 2016, Bacterial and viral infections in atopic dermatitis: a comprehensive review, Clin Rev Allergy Immunol, 51, 329, 10.1007/s12016-016-8548-5

Totte, 2016, Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis, Br J Dermatol, 175, 687, 10.1111/bjd.14566

Hazrati, 2006, Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection, J Immunol, 177, 8658, 10.4049/jimmunol.177.12.8658

Meyer-Hoffert, 2010, Increased expression of human beta-defensin 3 in mollusca contagiosum, Clin Exp Dermatol, 35, 190, 10.1111/j.1365-2230.2009.03640.x

Faergemann, 2002, Atopic dermatitis and fungi, Clin Microbiol Rev, 15, 545, 10.1128/CMR.15.4.545-563.2002

Tomalka, 2015, beta-Defensin 1 plays a role in acute mucosal defense against Candida albicans, J Immunol, 194, 1788, 10.4049/jimmunol.1203239

Donnarumma, 2004, Malassezia furfur induces the expression of beta-defensin-2 in human keratinocytes in a protein kinase C-dependent manner, Arch Dermatol Res, 295, 474, 10.1007/s00403-003-0445-0

Yuki, 2007, Tight junction proteins in keratinocytes: localization and contribution to barrier function, Exp Dermatol, 16, 324, 10.1111/j.1600-0625.2006.00539.x

Kuroda, 2010, Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function, J Dermatol Sci, 59, 107, 10.1016/j.jdermsci.2010.06.001

Yuki, 2016, Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17, PLoS One, 11, e0161759, 10.1371/journal.pone.0161759

Goto, 2013, Human beta defensin-1 regulates the development of tight junctions in cultured human epidermal keratinocytes, J Dermatol Sci, 71, 145, 10.1016/j.jdermsci.2013.04.017

Prado-Montes de Oca, 2007, Association of beta-defensin 1 single nucleotide polymorphisms with atopic dermatitis, Int Arch Allergy Immunol, 142, 211, 10.1159/000097023

Gwyer Findlay, 2013, Cationic host defence peptides: potential as antiviral therapeutics, BioDrugs, 27, 479, 10.1007/s40259-013-0039-0

Scudiero, 2010, Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity, Antimicrob Agents Chemother, 54, 2312, 10.1128/AAC.01550-09

Schroeder, 2011, Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1, Nature, 469, 419, 10.1038/nature09674