Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

Cancers - Tập 5 Số 2 - Trang 591-616
Kosei Ando1,2,3, Marie‐Françoise Heymann1,2,4,3, Verena Stresing2,4,3, Kanji Mori5, Françoise Rédiní1,2,4,3, Dominique Heymann1,2,4,3
1Equipe Labellisee Ligue 2012, Nantes, 44035 France
2INSERM, UMR 957, 1 Rue Gaston Veil, 44035 Nantes, France
3Physiopathologie de la Résorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Université de Nantes, Nantes Atlantique Universités, 1 Rue Gaston Veil, 44035 Nantes, France
4Nantes University Hospital, Nantes 44035, France
5Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan

Tóm tắt

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies.

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