Curcumin, inflammation, ageing and age-related diseases
Tóm tắt
A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini and Barbagallo is summarized. Ageing is manifested by the decreasing health status and increasing probability to acquire age-related disease such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others. They are likely caused by low grade inflammation driven by oxygen stress and manifested by the increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, encoded by genes activated by the transcription factor NF-κB. It is believed that ageing is plastic and can be slowed down by caloric restriction as well as by some nutraceuticals. Accordingly, slowing down ageing and postponing the onset of age-related diseases might be achieved by blocking the NF-κB-dependent inflammation. In this review we consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly.
Tài liệu tham khảo
Kirkwood TB: Evolution of ageing. Nature. 1977, 270: 301-304. 10.1038/270301a0.
Holliday R: Aging is no longer an unsolved problem in biology. Ann N Y Acad Sci. 2006, 1067: 1-9. 10.1196/annals.1354.002.
Kirkwood TB: A systematic look at an old problem. Nature. 2008, 451: 644-647. 10.1038/451644a.
Rattan SI: Increased molecular damage and heterogeneity as the basis of aging. Biol Chem. 2008, 389: 267-272. 10.1515/BC.2008.030.
Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956, 11: 298-300.
Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000, 908: 244-254. 10.1111/j.1749-6632.2000.tb06651.x.
Meyer KC: Aging. Proc Am Thorac Soc. 2005, 2: 433-439. 10.1513/pats.200508-081JS.
Pawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A: Cytomegalovirus and human immunosenescence. Rev Med Virol. 2009, 19: 47-56. 10.1002/rmv.598.
Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J: Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6: 2853-2868. 10.1371/journal.pbio.0060301.
Holliday R: The close relationship between biological aging and age-associated pathologies in humans. J Gerontol A Biol Sci Med Sci. 2004, 59: B543-546.
Chung HY, Sung B, Jung KJ, Zou Y, Yu BP: The molecular inflammatory process in aging. Antioxid Redox Signal. 2006, 8: 572-581. 10.1089/ars.2006.8.572.
Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C: Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009, 8: 18-30. 10.1016/j.arr.2008.07.002.
Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C: Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev. 2007, 128: 83-91. 10.1016/j.mad.2006.11.015.
Mantovani A, Allavena P, Sica A, Balkwill F: Cancer-related inflammation. Nature. 2008, 454: 436-444. 10.1038/nature07205.
Mantovani A: Cancer: Inflaming metastasis. Nature. 2009, 457: 36-37. 10.1038/457036b.
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70. 10.1016/S0092-8674(00)81683-9.
Csiszar A, Wang M, Lakatta EG, Ungvari Z: Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol. 2008, 105: 1333-1341. 10.1152/japplphysiol.90470.2008.
Finch CE, Morgan TE: Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res. 2007, 4: 185-189. 10.2174/156720507780362254.
Gupta A, Pansari K: Inflammation and Alzheimer's disease. Int J Clin Pract. 2003, 57: 36-39.
Vasto S, Candore G, Duro G, Lio D, Grimaldi MP, Caruso C: Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics. 2007, 8: 1735-1745. 10.2217/14622416.8.12.1735.
Hotamisligil GS: Inflammation and metabolic disorders. Nature. 2006, 444: 860-867. 10.1038/nature05485.
Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, Martin GM, Olshansky SJ: New model of health promotion and disease prevention for the 21st century. Bmj. 2008, 337: a399-10.1136/bmj.a399.
Vijg J, Campisi J: Puzzles, promises and a cure for ageing. Nature. 2008, 454: 1065-1071. 10.1038/nature07216.
Ravindran J, Prasad S, Aggarwal BB: Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?. Aaps J. 2009, 3: 495-510. 10.1208/s12248-009-9128-x.
Salvioli S, Sikora E, Cooper EL, Franceschi C: Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies. Evid Based Complement Alternat Med. 2007, 4: 181-190. 10.1093/ecam/nem043.
Singh S: From exotic spice to modern drug?. Cell. 2007, 130: 765-768. 10.1016/j.cell.2007.08.024.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H: Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007, 595: 1-75. full_text.
Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K: The promise of slow down ageing may come from curcumin. Current Pharmacological Design. 2010,
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T: Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev. 2008, 7: 83-105. 10.1016/j.arr.2007.09.002.
Calabrese V, Bates TE, Mancuso C, Cornelius C, Ventimiglia B, Cambria MT, Di Renzo L, De Lorenzo A, Dinkova-Kostova AT: Curcumin and the cellular stress response in free radical-related diseases. Mol Nutr Food Res. 2008, 52: 1062-1073. 10.1002/mnfr.200700316.
Cole GM, Teter B, Frautschy SA: Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007, 595: 197-212. full_text.
Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok V: Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol. 2008, 28: 110-113. 10.1097/jcp.0b013e318160862c.
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM: Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005, 280: 5892-5901. 10.1074/jbc.M404751200.
Chandra V, Pandav R, Dodge HH, Johnston JM, Belle SH, DeKosky ST, Ganguli M: Incidence of Alzheimer's disease in a rural community in India: the Indo-US study. Neurology. 2001, 57: 985-989.
Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH: Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006, 164: 898-906. 10.1093/aje/kwj267.
Berge U, Kristensen P, Rattan SI: Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Exp Gerontol. 2008, 43: 658-662. 10.1016/j.exger.2007.12.009.