Cumambrin A prevents OVX‐induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

Wiley - Tập 33 Số 6 - Trang 6726-6735 - 2019
Lin Zhou1,2, Qian Liu3,4,2, Guoju Hong5,2, Fangming Song3,4,2, Jinmin Zhao3,4, Jinbo Yuan2, Jun Xu6, Ren Xiang Tan7, Jennifer Tickner2, Qiong Gu6, Jiake Xu2
1Department of Endocrinology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
2School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia
3Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China
4Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China
5Orthopedic Department, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
6Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
7State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China

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10.1038/nature01658

10.1126/science.289.5484.1504

Lewellen T. K., 1977, Absolute measurement of total-body calcium by the Ar-37 method-preliminary results: concise communication, J. Nucl. Med., 18, 929

10.1006/bbrc.1998.8443

10.1111/brv.12353

Rular J., 2012, An overview of the regulation of bone remodelling at the cellular level, Clin. Biochem., 45, 863, 10.1016/j.clinbiochem.2012.03.021

Blair H. C., 2004, Recent advances in osteoclast biology and pathological bone resorption, Histol. Histopathol., 19, 189

10.1016/S0092-8674(00)81569-X

10.1038/16852

Takayanagi H., 2009, [Molecular determinants in osteoclast differentiation and osteoimmunology], Rinsho Ketsueki, 50, 447

10.1016/j.bbrc.2004.10.212

10.1111/j.1749-6632.2009.05245.x

Schmidt T. J., 1999, Toxic activities of sesquiterpene lactones: structural and biochemical aspects, Curr. Org. Chem., 3, 577

10.1074/jbc.M101985200

10.1006/cyto.1999.0526

10.1074/jbc.273.3.1288

10.1074/jbc.273.50.33508

10.1016/S0968-0896(99)00195-9

Tarasov V. A., 1974, Cumambrin A—a sesquiterpene lactone from Handelia trichophylla, Chem. Nat. Compd., 10, 10.1007/BF00564023

10.1359/JBMR.040919

10.1074/jbc.M901670200

10.1359/jbmr.2000.15.11.2178

10.1007/978-1-61779-415-5_2

10.1359/jbmr.2003.18.12.2159

10.1042/BJ20121626

10.3390/ijms161126039

10.1016/j.abb.2008.03.018

10.1016/j.molmed.2005.11.007

Jiang M., 2011, The role of Chinese medicine in the treatment of chronic diseases in China, Planta Med., 77, 873, 10.1055/s-0030-1270983

10.2196/resprot.7636

10.2174/1389450118666170321105425

Soysa N. S., 2012, Osteoclast formation and differentiation: an overview, J. Med. Dent. Sci., 59, 65

10.1038/nm1197-1285

Brown K. D., 2008, The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis, Arthritis Res. Ther., 10, 10.1186/ar2457

10.1016/S0955-0674(99)80030-1

10.1038/sj.onc.1203174

10.1016/S0092-8674(02)01166-2

10.1016/j.cytogfr.2008.11.007

10.1084/jem.20051150

10.1196/annals.1443.016

Leibbrandt A., 2011, Encyclopedia of Cancer, 3165, 10.1007/978-3-642-16483-5_4945

10.1196/annals.1402.071

10.1359/jbmr.2003.18.7.1198

10.1083/jcb.148.2.333

10.1038/nm1514

Jee W. S., 2001, Overview: animal models of osteopenia and osteoporosis, J. Musculoskelet. Neuronal Interact., 1, 193