Cross-Talk between Two Cysteine Protease Families
Tóm tắt
Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsible for cleaving the loop region in Bcl-xL and, therefore, turning an antiapoptotic molecule into a proapoptotic molecule. We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid β peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation. These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspase families.
Từ khóa
Tài liệu tham khảo
1995, The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families, Nat. Genet, 11, 219, 10.1038/ng1095-219
Begley, 1999, Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice, J. Neurochem, 72, 1030, 10.1046/j.1471-4159.1999.0721030.x
Bialik, 1999, The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes, Circ. Res., 85, 403, 10.1161/01.RES.85.5.403
Boise, 1993, bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death, Cell., 74, 597, 10.1016/0092-8674(93)90508-N
Buckley, 1997, Tunicamycin increases intracellular calcium levels in bovine aortic endothelial cells, Am. J. Physiol., 273, C1298, 10.1152/ajpcell.1997.273.4.C1298
Budihardjo, 1999, Biochemical pathways of caspase activation during apoptosis, Annu. Rev. Cell Dev. Biol., 15, 269, 10.1146/annurev.cellbio.15.1.269
Chan, 1999, Caspase and calpain substratesroles in synaptic plasticity and cell death, J. Neurosci. Res, 58, 167, 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K
Clem, 1998, Modulation of cell death by Bcl-XL through caspase interaction, Proc. Natl. Acad. Sci. USA., 95, 554, 10.1073/pnas.95.2.554
Croall, 1991, Calcium-activated neutral protease (calpain) systemstructure, function, and regulation, Physiol. Rev., 71, 813, 10.1152/physrev.1991.71.3.813
De Maria, 1999, Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1, Nature., 401, 489, 10.1038/46809
Edelstein, 1995, The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury, Proc. Natl. Acad. Sci. USA., 92, 7662, 10.1073/pnas.92.17.7662
Fujita, 1998, Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases, Oncogene., 17, 1295, 10.1038/sj.onc.1202065
Furuichi, 1989, Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400, Nature., 342, 32, 10.1038/342032a0
Gervais, 1999, Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation, Cell., 97, 395, 10.1016/S0092-8674(00)80748-5
Lee, 2000, Neurotoxicity induces cleavage of p35 to p25 by calpain, Nature., 405, 360, 10.1038/35012636
Leissring, 1999, Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes, J. Neurochem., 72, 1061, 10.1046/j.1471-4159.1999.0721061.x
Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell., 91, 479, 10.1016/S0092-8674(00)80434-1
Li, 1998, Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia, Neurosci. Lett., 247, 17, 10.1016/S0304-3940(98)00266-3
Markgraf, 1998, Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats, Stroke., 29, 152, 10.1161/01.STR.29.1.152
Nakagawa, 2000, Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid β, Nature., 403, 98, 10.1038/47513
Namura, 1998, Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia, J. Neurosci., 18, 3659, 10.1523/JNEUROSCI.18-10-03659.1998
Nath, 1996, Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1beta-converting-enzyme-like protease(s) in apoptotic cellscontributory roles of both protease families in neuronal apoptosis, Biochem. J, 319, 683, 10.1042/bj3190683
Patrick, 1999, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature., 402, 615, 10.1038/45159
Perez-Pinzon, 1999, Cytochrome c is released from mitochondria into the cytosol after cerebral anoxia or ischemia, J. Cereb. Blood Flow Metab., 19, 39, 10.1097/00004647-199901000-00004
Saido, 1994, Calpainnew perspectives in molecular diversity and physiological-pathological involvement, FASEB (Fed. Am. Soc. Exp. Biol.) J., 8, 814
Saito, 1993, Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer's diseasea potential molecular basis for neuronal degeneration, Proc. Natl. Acad. Sci. USA., 90, 2628, 10.1073/pnas.90.7.2628
Sanchez, 1999, Caspase-8 is required for cell death induced by expanded polyglutamine repeats, Neuron., 22, 623, 10.1016/S0896-6273(00)80716-3
Sawa, 1999, Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization, Nat. Med., 5, 1194, 10.1038/13518
Shields, 1998, Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis, Proc. Natl. Acad. Sci. USA., 95, 5768, 10.1073/pnas.95.10.5768
Shumway, 1999, The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain, J. Biol. Chem., 274, 30874, 10.1074/jbc.274.43.30874
Sidrauski, 1998, The unfolded protein responsean intracellular signalling pathway with many surprising features, Trends Cell Biol., 8, 245, 10.1016/S0962-8924(98)01267-7
Suzuki, 1987, Calcium-activated neutral protease and its endogenous inhibitor. Activation at the cell membrane and biological function, FEBS (Fed. Eur. Biochem Soc.) Lett., 220, 271, 10.1016/0014-5793(87)80828-1
Thornberry, 1992, A novel heterodimeric cysteine protease is required for interleukin-1beta processing in monocytes, Nature., 356, 768, 10.1038/356768a0
Toda, 1989, Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction, Jpn. Heart. J, 30, 375, 10.1536/ihj.30.375
Tsuji, 1998, m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains, Neurosci. Lett., 248, 109, 10.1016/S0304-3940(98)00348-6
Wang, 1989, Calmodulin-binding proteins as calpain substrates, Biochem. J., 262, 693, 10.1042/bj2620693
Yokota, 1999, Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage, Brain Res., 819, 8, 10.1016/S0006-8993(98)01334-1