Creating the Gene Ontology Resource: Design and Implementation

Genome Research - Tập 11 Số 8 - Trang 1425-1433 - 2001
The Gene Ontology Consortium

Tóm tắt

The exponential growth in the volume of accessible biological information has generated a confusion of voices surrounding the annotation of molecular information about genes and their products. The Gene Ontology (GO) project seeks to provide a set of structured vocabularies for specific biological domains that can be used to describe gene products in any organism. This work includes building three extensive ontologies to describe molecular function, biological process, and cellular component, and providing a community database resource that supports the use of these ontologies. The GO Consortium was initiated by scientists associated with three model organism databases: SGD, the Saccharomyces Genome database; FlyBase, the Drosophila genome database; and MGD/GXD, the Mouse Genome Informatics databases. Additional model organism database groups are joining the project. Each of these model organism information systems is annotating genes and gene products using GO vocabulary terms and incorporating these annotations into their respective model organism databases. Each database contributes its annotation files to a shared GO data resource accessible to the public athttp://www.geneontology.org/. The GO site can be used by the community both to recover the GO vocabularies and to access the annotated gene product data sets from the model organism databases. The GO Consortium supports the development of the GO database resource and provides tools enabling curators and researchers to query and manipulate the vocabularies. We believe that the shared development of this molecular annotation resource will contribute to the unification of biological information.

Từ khóa


Tài liệu tham khảo

10.1126/science.287.5461.2185

10.1093/nar/28.1.45

10.1093/nar/28.1.77

10.1093/nar/28.1.108

Delozier, 1992, MEDLINE and MeSH: Challenges for end users., Med. Ref. Serv. Q, 11, 29, 10.1300/J115V11N03_03

10.1006/knac.1993.1008

10.1006/ijhc.1995.1081

Guarino N. , ed(1998) Formal ontology in information systems (IOS Press, Washington, DC.) ibid.

10.1093/nar/29.1.102

10.1016/S0169-023X(99)00022-1

10.1093/nar/28.1.56

10.1001/jama.1994.03510380059038

Oxford Dictionary of Biochemistry and Molecular Biology. 1997. (eds. A.D. Smith, et al.) Oxford University Press, NY..

Riley, 1993, Functions of the gene products of Escherichia coli., Microbiol. Rev., 57, 862, 10.1128/mr.57.4.862-952.1993

10.1093/nar/28.1.115

Rison, 2000, Comparison of functional annotation schemes for genomes., Func. Integ. Genom., 1, 56, 10.1007/s101420000005

Schulze-Kremer S. Karp P.D. Musen M.A. Altman R.B. (1998) Ontologies for molecular biology tutorial. 6th International Conference on Intelligent Systems for Molecular Biology, Montreal, Canada..

10.1093/nar/27.1.85

10.1038/75556

Thông tin
Thông tin xuất bản

Genome Research

Tập 11 Số 8

1425-1433

Thông tin tác giả