Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?

mBio - Tập 9 Số 3 - 2018
Eric V. Stabb1
1Department of Microbiology, University of Georgia, Athens, Georgia, USA

Tóm tắt

ABSTRACT Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unified and popularized the field, bacterial PS clearly has roles beyond census taking, and the complexities of PS circuits indicate broader functional capacities. Two common features of bacterial PS are its regulation in response to environmental conditions and positive-feedback loops. Combined, these could enable PS to coordinate quorum-dependent group behaviors in response to heterogeneous environmental cues. Particularly in PS systems where positive feedback is strong, cells that are relatively far from a stimulatory environment could be recruited to a group response. Testing this model will benefit from in situ examination of relevant environmental cues and PS outputs in cells across populations, with and without positive feedback, in heterogeneous environments.

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Tài liệu tham khảo

10.1038/183055a0

10.1128/jb.104.1.313-322.1970

10.1111/1574-6976.12046

10.1073/pnas.75.7.3479

10.3109/10408418609108741

10.3389/fmicb.2014.00054

10.1128/jb.176.2.269-275.1994

10.1111/j.1574-6941.2009.00745.x

10.1016/j.tim.2010.05.003

10.1016/S1369-5274(03)00028-6

10.1128/MMBR.00024-14

10.1016/S0966-842X(02)02400-9

10.1038/nrmicro1600

10.1016/S1369-5274(02)00304-1

10.1111/j.1574-6968.2008.01478.x

10.1016/j.tim.2012.09.004

10.1098/rsif.2012.1009

10.1146/annurev-genet-102108-134304

10.1016/S0021-9258(18)42571-9

10.1128/jb.176.10.2796-2806.1994

10.1007/BF02191645

Atkinson S, Sockett RE, Cámara M, Williams P. 2006. Quorum sensing and the lifestyle of Yersinia. Curr Issues Mol Biol 8:1–10.

10.1128/JB.05125-11

10.1128/mBio.01079-17

10.1186/1752-0509-5-153

10.1038/msb.2011.30

10.1038/nrmicro3491

10.1128/AEM.00900-15

10.3389/fmicb.2015.00767

10.1038/msb.2008.70

10.1016/B978-0-12-381043-4.00002-7

10.3390/s120404156

10.1371/journal.pone.0049590

10.1021/ja211593q

10.1016/j.jtbi.2014.07.033

Stabb EV. 2005. Shedding light on the bioluminescence “paradox.” ASM News 71:223–229.

10.1038/nrmicro.2015.8

10.1111/j.1574-6941.2005.00037.x

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