Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin
Tóm tắt
Coffee silverskin is a thin film that covers the raw coffee bean. In general, coffee silverskin, which detaches during the coffee roasting process, is disposed as firelighters or dispatched to landfills and can cause serious environmental pollution. The aim of this study was to investigate the feasibility of using coffee silverskin as a functional material in cosmetics by evaluating its bioactive ingredients, antioxidative activity, cytoprotective effect, matrix metalloproteinase-1 (MMP-1)-inhibiting effect, and anti-melanogenesis effect. To this end, a 50% ethanol (EtOH) extract and its ethyl acetate (EtOAc) fraction were prepared from coffee silverskin; caffeine was found to be the major compound in the extract. Both the 50% EtOH extract and its EtOAc fraction exhibited antioxidant activities. However, the EtOAc fraction showed a greater radical-scavenging activity and reducing power than that shown by the 50% EtOH extract. Furthermore, the EtOAc fraction increased cell viability in a UVB-irradiated human keratinocyte injury model and significantly suppressed UVB-induced MMP-1 expression and α-melanocyte-stimulating hormone (α-MSH)-stimulated melanin production in HaCaT keratinocytes and B16F1 melanocytes, respectively. Interestingly, caffeine, the major component of the EtOAc fraction, did not show an inhibitory effect. Thus, the antioxidant capacity of the coffee silverskin extract may be attributable to some compounds that exhibit a high antioxidant capacity even at low concentrations or the total antioxidant capacity of various constituent phenolic compounds. Our findings indicate that coffee silverskin has the potential for application as a natural functional material in multifunctional cosmetics.
Tài liệu tham khảo
Wlaschek M, Tantcheva-Poor I, Naderi L, Ma WJ, Schneider A, Razi-Wolf Z, Schuller J, Scharffetter-Kochanek K. Solar UV irradiation and dermal photoaging. J Photoch Photobio B. 2001;63:41–51.
Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev. 2015;21:16–29.
Xuan SH, Park YM, Ha JH, Jeong YJ, Park SN. The effect of dehydroglyasperin C on UVB-mediated MMPs expression in human HaCaT cells. Pharmacol Rep. 2017;69:1224–31.
Park SN. Skin aging and antioxidant. J Soc Cosmet Scientists Korea. 1997;23:75–132.
Wohlrab J, Hilpert K, Wolff L. Epidermal aging and anti-aging strategies. Hautarzt. 2016;67:107–11.
Park SN, Kim SY, Lim GN, Jo NR, Lee MH. In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts. J Ind Eng Chem. 2012;18:680–3.
Martini D, Del Bo C, Tassotti M, Riso P, Del Rio D, Brighenti F, Porrini M. Coffee consumption and oxidative stress: a review of human intervention studies. Molecules. 2016;21:1–20.
International Coffee Orcanization, http://www.ico.org/, (Accessed 10 Apr 2018).
Bresciani L, Calani L, Bruni R, Brighenti F, Del Rio D. Phenolic composition, caffeine content and antioxidant capacity of coffee silverskin. Food Res Int. 2014;61:196–201.
Rodrigues F, Palmeira-de-Oliveira A, das Neves J, Sarmento B, Amaral MH, Oliveira MB. Coffee silverskin: a possible valuable cosmetic ingredient. Pharm Biol. 2015;53:386–94.
Borrelli RC, Esposito F, Napolitano A, Ritieni A, Fogliano V. Characterization of a new potential functional ingredient: coffee silverskin. J Agric Food Chem. 2004;52:1338–43.
Furusawa M, Narita Y, Iwai K, Fukunaga T, Nakagiri O. Inhibitory effect of a hot water extract of coffee “silverskin” on hyaluronidase. Biosci Biotechnol Biochem. 2011;75:1205–7.
Alves RC, Costa AS, Jerez M, Casal S, Sineiro J, Nunez MJ, Oliveira B. Antiradical activity, phenolics profile, and hydroxymethylfurfural in espresso coffee: influence of technological factors. J Agric Food Chem. 2010;58:12221–9.
Seong JS, Xuan SH, Park SH, Lee KS, Park YM, Park SN. Antioxidative and antiaging activities and component analysis of Lespedeza cuneata G. Don extracts fermented with Lactobacillus pentosus. J Microbiol Biotechnol. 2017;27:1961–70.
Silvan JM, Reguero M, de Pascual-Teresa S. A protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells. Food Funct. 2016;7:1067–76.
Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20:933–56.
Kim EK, Lee SJ, Lim BO, Jeon YJ, Song MD, Park TK, Lee KH, Kim B, Lee SR, Moon SH, Jeon BT, Park PJ. Antioxidative and neuroprotective effects of enzymatic extracts from leaves of Perilla frutescens var. japonica. Food Sci Biotechnol. 2008;17:279–86.
Hwang JP, Ha JH, No GY, Jeong YJ, Park SN. Cellular protective effect of novel dimeric ferulamide derivatives against UVA and 1O2 and its structural mechanism. J Ind Eng Chem. 2017;53:164–70.
Schuch AP, Moreno NC, Schuch NJ, Menck CFM, Garcia CCM. Sunlight damage to cellular DNA: focus on oxidatively generated lesions. Free Radic Biol Med. 2017;107:110–24.
Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337:1419–28.
Bosch R, Philips N, Suarez-Perez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, Gonzalez S. Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals. Antioxidants (Basel). 2015;4:248–68.
Chao WW, Su CC, Peng HY, Chou ST. Melaleuca quinquenervia essential oil inhibits alpha-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells. Phytomedicine. 2017;34:191–201.
Lephart ED. Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms. Ageing Res Rev. 2016;31:36–54.
Rittie L, Fisher GJ. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med. 2015;5:a015370. https://doi.org/10.1101/cshperspect.a015370.
Meng TX, Irino N, Kondo R. Melanin biosynthesis inhibitory activity of a compound isolated from young green barley (Hordeum vulgare L.) in B16 melanoma cells. J Nat Med. 2015;69:427–31.
Perez-Sanchez A, Barrajon-Catalan E, Herranz-Lopez M, Castillo J, Micol V. Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and prevents UVB-induced oxidative stress and DNA damage in a skin cell model. J Dermatol Sci. 2016;84:169–77.
Hwang YP, Oh KN, Yun HJ, Jeong HG. The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells. J Dermatol Sci. 2011;61:23–31.
Brash DE. UV-induced melanin Chemiexcitation: a new mode of melanoma pathogenesis. Toxicol Pathol. 2016;44:552–4.
Costin GE, Hearing VJ. Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J. 2007;21:976–94.
Regazzoni L, Saligari F, Marinello C, Rossoni G, Aldini G, Carini M, Orioli M. Coffee silver skin as a source of polyphenols: high resolution mass spectrometric profiling of components and antioxidant activity. J Funct Foods. 2016;20:472–85.