Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different <i>Mycobacterium tuberculosis</i> genotypes in a BALB/c mouse model

Clinical and Experimental Immunology - Tập 137 Số 3 - Trang 460-468 - 2004
J. A. M. A. Dormans1, Marion Burger2, D Aguilar3, Rogelio Hernández‐Pando3, Kristin Kremer2, Paul Roholl4, Sandra M. Arend5, Dick van Soolingen2
1Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and Environment (RIVM), Bilthoven, The Netherlands.
2Mycobacterial Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven and
3Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition ‘Salvador Zubirán’, México
4Laboratory for Toxicology, Pathology and Genetics and
5Department of Infectious Diseases, Leiden University Medical Centre, Leiden, the Netherlands and

Tóm tắt

SUMMARY One of the most intriguing aspects of tuberculosis is that the outcome of an infection with M. tuberculosis (TB) is highly variable between individuals. The possibility of differences in virulence between M. tuberculosis strains or genotypes has only recently been studied. There is evidence of multifactorial genetic predisposition in humans that influences the susceptibility to tuberculosis. A better understanding of differences in virulence between M. tuberculosis genotypes could be important with regard to the efforts at TB control and the development of improved antituberculosis vaccines. Survival, lung pathology, bacterial load and delayed type hypersensitivity (DTH) responses of BALB/c mice after intratracheal infection with any of 19 different M. tuberculosis complex strains of 11 major genotype families were studied. The results indicate that among genetically different M. tuberculosis strains a very broad response was present with respect to virulence, pathology, bacterial load and DTH. ‘Low’-responders were the H37Rv, Canetti, Beijing-1 strains, while Beijing-2,3, Africa-2 and Somalia-2 strains were ‘high’-responders. A severe pathological response correlates with a high mortality and a high CFU counts in lungs, but poorly with the degree of the DTH response.

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Clinical and Experimental Immunology

Tập 137 Số 3

460-468

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