Correlation between antiangiogenic activity and antioxidant activity of various components from propolis

Molecular Nutrition and Food Research - Tập 53 Số 5 - Trang 643-651 - 2009
Mok‐Ryeon Ahn1, Kazuhiro Kunimasa2, Shigenori Kumazawa2, Tsutomu Nakayama2, Kazuhiko Kaji2, Yoshihiro Uto3, Hitoshi Hori3, Hideko Nagasawa4, Toshiro Ohta
1Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka, Shizuoka, Japan
2Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka, Shizuoka, Japan. Fax: +81-54-264-5571
3Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan.
4Faculty of Pharmaceutical Science, Gifu Pharmaceutical University, Gifu, Japan

Tóm tắt

AbstractPropolis possesses various physiological activities. In this study, we examined the antiangiogenic and antioxidant activities of various components from propolis: acacetin, apigenin, artepillin C, caffeic acid phenethyl ester, chrysin, p‐coumaric acid, galangin, kaempferol, pinocembrin, and quercetin. The effects of these components were tested on in vitro models of angiogenesis, tube formation and growth of human umbilical vein endothelial cells (HUVECs). Furthermore, these components were evaluated for their antioxidant activities by 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical‐scavenging and ferric reducing/antioxidant power (FRAP) assays. Two propolis components, caffeic acid phenethyl ester, and quercetin, possessed strong inhibitory effects on tube formation and on endothelial cell proliferation and, coincidentally, showed strong antioxidant activity. Artepillin C, galangin, and kaempferol also possessed strong antiangiogenic and antioxidant activities to a slightly less degree. In contrast, acacetin, apigenin, and pinocembrin possessed a considerable degree of antiangiogenic activities, although they showed very low antioxidant activities. From these results, we propose that components from propolis such as artepillin C, caffeic acid phenethyl ester, galangin, kaempferol, and quercetin might represent a new class of dietary‐derived antioxidative compounds with antiangiogenic activities. These propolis components may have the potential to be developed into pharmaceutical drugs for the treatment of angiogenesis‐dependent human diseases such as tumors.

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Molecular Nutrition and Food Research

Tập 53 Số 5

643-651

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