Coronavirus infections and immune responses

Journal of Medical Virology - Tập 92 Số 4 - Trang 424-432 - 2020
Geng Li1,2, Yaohua Fan3, Yanni Lai3, Tiantian Han3, Zonghui Li2, Peiwen Zhou1, Pan Pan2, Wenbiao Wang1, Dingwen Hu4, Xiaohong Liu5, Qiwei Zhang1,6, Jianguo Wu1,4
1Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China
2Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China
3The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
5The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
6School of Pubic Health, Southern Medical University, Guangzhou, China

Tóm tắt

Abstract

Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV‐induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.

Từ khóa


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Journal of Medical Virology

Tập 92 Số 4

424-432

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