Coronary Tone Modulation: Formation and Actions of Prostaglandins, Endoperoxides, and Thromboxanes

American Association for the Advancement of Science (AAAS) - Tập 195 Số 4276 - Trang 409-412 - 1977
Philip Needleman1, Prasad S. Kulkarni1, Amiram Raz1
1Department of Pharmacology, Washington University Medical School, St. Louis, Missouri 63110

Tóm tắt

Exogenous prostaglandin (PGE 2 ) contracts bovine and human coronary arteries but its precursor, arachidonic acid, relaxes them. The endoperoxides PGH 2 and PGH 3 relax bovine coronary strips, but PGH 1 produces contraction. The primary prostaglandins exert opposite effects to their own endoperoxide precursors, thus, PGE 2 and PGE 3 contract, and PGE 1 relaxes the bovine coronary arteries. The paradoxical coronary dilation produced by the arachidonate or the PGH 2 suggest that little if any coronary isomerase which converts endoperoxide into PGE 2 exists, or that a novel, potent, PG-like substance is produced by the isolated coronary arteries. Although the coronaries do not possess thromboxane A 2 synthetase activity, the vessels are profoundly contracted by exogenous thromboxane A 2 . Thromboxane A 2 can be synthesized and released by circulating platelets when they are aggregated by endothelial injury or thrombin. Thus, coronary tone, and possible spasm, in ischemic myocardial zones may be influenced markedly by interplay between prostaglandins, endoperoxides, and thromboxane formed by platelets on the one hand, and endoperoxide products synthesized endogenously in the coronary arteries on the other.

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Tài liệu tham khảo

AIKEN, W.J., POL J PHARMACOL PHAR 26: 217 (1974).

BUNTING, S, BRIT J PHARMACOL 56: 344 (1976).

ELLIS, E.F., CIRCULATION 52: 496 (1975).

10.1126/science.959827

FURCHGOTT, R.F., REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 108: 129 (1953).

GIMBRONE, M.A., ANGIOTENSIN-2 STIMULATION OF PROSTAGLANDIN PRODUCTION IN CULTURED HUMAN VASCULAR ENDOTHELIUM, SCIENCE 189: 219 (1975).

HAMBERG, M, THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2994 (1975).

HAMBERG, M, PROSTAGLANDIN ENDOPEROXIDES - NEW CONCEPT CONCERNING MODE OF ACTION AND RELEASE OF PROSTAGLANDINS .6., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 3824 (1974).

Hintze, T. H., Circulation Research 40: 313 (1977).

Isakson, P. C., Proceedings of the National Academy of Sciences of the United States of America 74: 101 (1977).

KALSNER, S, ENDOGENOUS PROSTAGLANDIN RELEASE CONTRIBUTES DIRECTLY TO CORONARY-ARTERY TONE, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 53: 560 (1975).

KULKARNI, P. S., FEDERATION PROCEEDINGS 35: 298 (1976).

KULKARNI, P.S., PARADOXICAL ENDOGENOUS SYNTHESIS OF A CORONARY DILATING SUBSTANCE FROM ARACHIDONATE, PROSTAGLANDINS 12: 337 (1976).

NEEDLEMAN, P, EUR J PHARMACOLOGY 66: 316 (1973).

NEEDLEMAN, P, IDENTIFICATION OF AN ENZYME IN PLATELET MICROSOMES WHICH GENERATES THROMBOXANE-A-2 FROM PROSTAGLANDIN ENDOPEROXIDES, NATURE 261: 558 (1976).

NEEDLEMAN, P, THROMBOXANES - SELECTIVE BIOSYNTHESIS AND DISTINCT BIOLOGICAL PROPERTIES, SCIENCE 193: 163 (1976).

PIPER, P.J., RELEASE OF ADDITIONAL FACTORS IN ANAPHYLAXIS AND ITS ANTAGONISM BY ANTI-INFLAMMATORY DRUGS, NATURE 223: 29 (1969).

Raz A. Prostaglandins in press.

TERRAGNO, D.A., PROSTAGLANDIN SYNTHESIS BY BOVINE MESENTERIC-ARTERIES AND VEINS, CIRCULATION RESEARCH 36: 76 (1975).

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American Association for the Advancement of Science (AAAS)

Tập 195 Số 4276

409-412

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