Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling

Li Zhou1, Fan Yang2, Guobing� Li1, Jingbin� Huang1, Yali Liu1, Qian Zhang1, Qin Tang1, Changpeng� Hu1, Rong Zhang1
1Department of Pharmacy, The Second Affiliated Hospital, Third Military Medical University, Chongqing, China
2Department of Orthopaedic, General Hospital of Tibetan Military Command Lhasa, Lhasa, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Boege, 2017, A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development., Cancer Cell, 32, 342.e10, 10.1016/j.ccell.2017.08.010

Dorchies, 2009, Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallate., Biofactors, 35, 279, 10.1002/biof.34

Fan, 2017, Pekinenin E inhibits the growth of hepatocellular carcinoma by promoting endoplasmic reticulum stress mediated cell death., Front. Pharmacol., 8, 10.3389/fphar.2017.00424

Gravitz, 2014, Liver cancer., Nature, 4, 10.1038/516S1a

Hu, 2017, Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress., Biomed. Pharmacother., 85, 313, 10.1016/j.biopha.2016.11.031

Huang, 2017, Coptisine from Rhizoma Coptidis suppresses HCT-116 cells-related tumor growth in vitro and in vivo., Sci. Rep., 7, 10.1038/srep38524

Huang, 2015, Interleukin-8 Induces Expression of FOXC1 to promote transactivation of CXCR1 and CCL2 in hepatocellular carcinoma cell lines and formation of metastases in mice., Gastroenterology, 149, e14, 10.1053/j.gastro.2015.05.058

Huang, 2017, Proteasome Inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells., Front. Pharmacol., 8, 10.3389/fphar.2017.00476

Huang, 2017, Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor., Chem. Commun., 53, 1941, 10.1039/c6cc09504f

Iizuka, 2016, The transcription factor carbohydrate-response element-binding protein (ChREBP): a possible link between metabolic disease and cancer., Biochim. Biophys. Acta, 1863, 474, 10.1016/j.bbadis.2016.11.029

Iizuka, 2002, Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma., Int. J. Cancer, 99, 286, 10.1002/ijc.10338

Jin, 2017, Regulator of calcineurin 1 Gene Isoform 4, down-regulated in hepatocellular carcinoma, prevents proliferation, migration, and invasive activity of cancer cells and metastasis of orthotopic tumors by inhibiting nuclear translocation of NFAT1., Gastroenterology, 153, e33, 10.1053/j.gastro.2017.05.045

Jovanovic, 2015, Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer’s disease., Expert Opin. Ther. Pat., 25, 567, 10.1517/13543776.2015.1014802

Kou, 2016, Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters., Life Sci., 151, 50, 10.1016/j.lfs.2016.02.046

Kumazoe, , Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis., FEBS Lett., 587, 3052, 10.1016/j.febslet.2013.07.041

Kumazoe, , 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis., J. Clin. Invest., 123, 787, 10.1172/jci64768

Kwon, 2008, Evaluation of antibacterial effects of a combination of Coptidis Rhizoma, Mume Fructus, and Schizandrae Fructus against Salmonella., Int. J. Food Microbiol., 127, 180, 10.1016/j.ijfoodmicro.2008.06.020

Li, 2015, Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis., Oncotarget, 6, 1834, 10.18632/oncotarget.2795

Li, 2017, Comparative metabolism study of five protoberberine alkaloids in liver microsomes from rat, rhesus monkey, and human., Planta Med., 83, 1281, 10.1055/s-0043-108249

Lin, 2004, Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth., Clin. Exp. Pharmacol. Physiol., 31, 65, 10.1111/j.1440-1681.2004.03951.x

Lu, 2016, Inhibition of human 67-kDa laminin receptor sensitizes multidrug resistance colon cancer cell line SW480 for apoptosis induction., Tumour Biol., 37, 1319, 10.1007/s13277-015-3873-5

Lu, 2013, Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction., Int. J. Oncol., 42, 229, 10.3892/ijo.2012.1704

Lv, 2015, WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1., J. Exp. Clin. Cancer Res., 34, 10.1186/s13046-015-0233-7

Mocanu, 2014, Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells., J. Nat. Prod., 77, 250, 10.1021/np4007712

Montuori, 2016, 67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?, Transl. Med. UniSa, 15, 8

Pesapane, 2017, Recent advances in the function of the 67 kDa laminin receptor and its targeting for personalized therapy in cancer., Curr. Pharm. Des., 23, 4745, 10.2174/1381612823666170710125332

Rao, 2017, Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells., Tumour Biol., 39, 10.1177/1010428317694565

Saravani, 2012, Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468., Cell Prolif., 45, 199, 10.1111/j.1365-2184.2012.00819.x

Song, 2012, Expression of 67-kDa laminin receptor was associated with tumor progression and poor prognosis in epithelial ovarian cancer., Gynecol. Oncol., 125, 427, 10.1016/j.ygyno.2012.01.030

Tsukamoto, 2012, Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells., Biochem. J., 443, 525, 10.1042/bj20111837

Tsukamoto, 2015, Sphingosine Kinase-1 protects multiple myeloma from apoptosis driven by cancer-specific inhibition of RTKs., Mol. Cancer Ther., 14, 2303, 10.1158/1535-7163.mct-15-0185

Wu, 2016, Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells., Eur. J. Pharmacol., 780, 106, 10.1016/j.ejphar.2016.03.037

Xu, 2017, Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2., J. Exp. Clin. Cancer Res., 36, 10.1186/s13046-017-0514-4

Yang, 2017, Adropin is a key mediator of hypoxia induced anti-dipsogenic effects via TRPV4-CamKK-AMPK signaling in the circumventricular organs of rats., Front. Mol. Neurosci., 10, 10.3389/fnmol.2017.00105

Yoshimoto, 2013, Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome., Nature, 499, 97, 10.1038/nature12347

Yu, 2014, Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms., Toxicol. Lett., 226, 328, 10.1016/j.toxlet.2014.02.021

Zhang, 2014, Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system., Chin. J. Nat. Med., 12, 428, 10.1016/s1875-5364(14)60067-4

Zhang, 2016, Indazolo[3,2-b]quinazolinones attack hepatocellular carcinoma Hep3B cells by inducing mitochondrial-dependent apoptosis and inhibition of Nrf2/ARE signaling pathway., Curr. Mol. Med., 16, 820, 10.2174/1566524016666161128114444

Zhou, 2016, Compound K attenuates the development of atherosclerosis in ApoE(-/-) Mice via LXRalpha activation., Int. J. Mol. Sci., 8, 10.3390/ijms17071054

Zhou, 2016, Improving the anticancer efficacy of laminin receptor-specific therapeutic ruthenium nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent apoptosis in SMMC-7721 Cells., ACS Appl. Mater. Interfaces, 8, 15000, 10.1021/acsami.5b02261