Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics
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Double, 2010, Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions?, Progress Neurobiol., 92, 316, 10.1016/j.pneurobio.2010.06.001
Barnham, 2008, Metals in Alzheimer's and Parkinson's diseases, Curr. Opin. Chem. Biol., 12, 222, 10.1016/j.cbpa.2008.02.019
Ward, 2012, Chelating agents for neurodegenerative diseases, Curr. Med. Chem., 19, 2760, 10.2174/092986712800609689
Sutachan, 2012, Cellular and molecular mechanisms of antioxidants in Parkinson's disease, Nutr. Neurosci., 15, 120, 10.1179/1476830511Y.0000000033
Bandmann, 2015, Wilson's disease and other neurological copper disorders, Lancet Neurol., 14, 103, 10.1016/S1474-4422(14)70190-5
Zlatic, 2015, Fluphenazine.HCl and epigallocatechin gallate modulate the rate of formation and structural properties of apolipoprotein C-II Amyloid Fibrils, Biochemistry, 54, 3831, 10.1021/acs.biochem.5b00399
Davies, 2013, Localization of copper and copper transporters in the human brain, Metallomics, 5, 43, 10.1039/C2MT20151H
Dexter, 1991, Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia, Brain, 114, 1953, 10.1093/brain/114.4.1953
Bohic, 2008, Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy, Anal. Chem., 80, 9557, 10.1021/ac801817k
Lutsenko, 2008, Cellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance, Arch. Biochem. Biophys., 476, 22, 10.1016/j.abb.2008.05.005
Brewer, 2008, The risks of free copper in the body and the development of useful anticopper drugs, Curr. Opin. Clin. Nutr. Metab. Care, 11, 727, 10.1097/MCO.0b013e328314b678
Bauerly, 2004, Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment, J. Nutr. Biochem., 15, 155, 10.1016/j.jnutbio.2003.10.008
Kuo, 2006, Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status, J. Nutr., 136, 21, 10.1093/jn/136.1.21
Nevitt, 2012, Charting the travels of copper in eukaryotes from yeast to mammals, Biochim. Biophys. Acta, 1823, 1580, 10.1016/j.bbamcr.2012.02.011
Ohgami, 2006, The Steap proteins are metalloreductases, Blood, 108, 1388, 10.1182/blood-2006-02-003681
Kelly, 1996, A murine model of Menkes disease reveals a physiological function of metallothionein, Nat. Genet., 13, 219, 10.1038/ng0696-219
Klomp, 1996, Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia, Hum. Mol. Genet., 5, 1989, 10.1093/hmg/5.12.1989
Yoshida, 1995, A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans, Nat. Genet., 9, 267, 10.1038/ng0395-267
Harris, 1995, Aceruloplasminemia: molecular characterization of this disorder of iron metabolism, Proc. Natl. Acad. Sci. U.S.A., 92, 2539, 10.1073/pnas.92.7.2539
Culotta, 1997, The copper chaperone for superoxide dismutase, J. Biol. Chem., 272, 23469, 10.1074/jbc.272.38.23469
Beers, 1997, Purification, characterization, and localization of yeast Cox17p, a mitochondrial copper shuttle, J. Biol. Chem., 272, 33191, 10.1074/jbc.272.52.33191
Cobine, 2006, Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase, J. Biol. Chem., 281, 36552, 10.1074/jbc.M606839200
Cobine, 2004, Yeast contain a non-proteinaceous pool of copper in the mitochondrial matrix, J. Biol. Chem., 279, 14447, 10.1074/jbc.M312693200
Maxfield, 2004, Cox17 is functional when tethered to the mitochondrial inner membrane, J. Biol. Chem., 279, 5072, 10.1074/jbc.M311772200
Lee, 2001, Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development, Proc. Natl. Acad. Sci. U.S.A., 98, 6842, 10.1073/pnas.111058698
Takahashi, 2002, Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development, Mol. Cell Biol., 22, 7614, 10.1128/MCB.22.21.7614-7621.2002
Oswald, 2009, Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase, J. Mol. Biol., 389, 470, 10.1016/j.jmb.2009.04.034
Leary, 2004, Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase, Hum. Mol. Genet., 13, 1839, 10.1093/hmg/ddh197
Rothstein, 1999, The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain, J. Neurochem., 72, 422, 10.1046/j.1471-4159.1999.0720422.x
Kim, 2009, Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis, Am. J. Physiol. Gastrointest. Liver Physiol., 296, G356, 10.1152/ajpgi.90632.2008
Lee, 2002, Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system, J. Biol. Chem., 277, 40253, 10.1074/jbc.M208002200
Ip, 2010, Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue, Mol. Pain, 6, 53, 10.1186/1744-8069-6-53
Mercer, 1993, Isolation of a partial candidate gene for Menkes disease by positional cloning, Nat. Genet., 3, 20, 10.1038/ng0193-20
Gouider-Khouja, 2009, Wilson's disease, Parkinsonism Relat. Disord., 15, S126, 10.1016/S1353-8020(09)70798-9
Capo, 2008, Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer's disease patients, Biometals, 21, 367, 10.1007/s10534-007-9125-4
Holtzman, 1970, Studies on the rate of release and turnover of ceruloplasmin and apoceruloplasmin in rat plasma, J. Biol. Chem., 245, 2354, 10.1016/S0021-9258(18)63159-X
Gaetke, 2003, Copper toxicity, oxidative stress, and antioxidant nutrients, Toxicology, 189, 147, 10.1016/S0300-483X(03)00159-8
Valko, 2005, Metals, toxicity and oxidative stress, Curr. Med. Chem., 12, 1161, 10.2174/0929867053764635
Litwin, 2013, Brain metal accumulation in Wilson's disease, J. Neurol. Sci., 329, 55, 10.1016/j.jns.2013.03.021
Gray, 2012, Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load, PloS One, 7, e38327, 10.1371/journal.pone.0038327
Kim, 2010, Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs, Cell Metab., 11, 353, 10.1016/j.cmet.2010.04.003
Campanella, 1973, Iron, transferrin, copper and ceruloplasmin of the serum and cerebrospinal fluid in extrapyramidal diseases and primary myopathies. Study in basic conditions and in Parkinsonism after treatment with dopaminergic agents (L-dopa, L-dopa + RO 4–4602, amantadine), Acta Neurol., 28, 1
Jimenez-Jimenez, 1992, Serum levels of zinc and copper in patients with Parkinson's disease, J. Neurol. Sci., 112, 30, 10.1016/0022-510X(92)90127-7
Jimenez-Jimenez, 1998, Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease, J. Neural. Transm., 105, 497, 10.1007/s007020050073
Pall, 1987, Raised cerebrospinal-fluid copper concentration in Parkinson's disease, Lancet, 2, 238, 10.1016/S0140-6736(87)90827-0
Torsdottir, 1999, Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease, Pharmacol. Toxicol., 85, 239, 10.1111/j.1600-0773.1999.tb02015.x
Arnal, 2010, Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives, Brain Res., 1319, 118, 10.1016/j.brainres.2009.11.085
Mariani, 2013, Fe and Cu do not differ in Parkinson's disease: a replication study plus meta-analysis, Neurobiol. Aging, 34, 632, 10.1016/j.neurobiolaging.2012.05.015
Gazzaniga, 1992, A case control study of CSF copper, iron and manganese in Parkinson disease, Ital. J. Neurol. Sci., 13, 239, 10.1007/BF02224396
Takahashi, 1994, Trace elements analysis of serum and cerebrospinal fluid with PIXE–effect of age and changes in parkinsonian patients, Nippon Ronen Igakkai Zasshi, 31, 865, 10.3143/geriatrics.31.865
Loeffler, 1994, Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease, Alzheimer Dis. Assoc. Disord., 8, 190, 10.1097/00002093-199408030-00005
Davies, 2014, Copper pathology in vulnerable brain regions in Parkinson's disease, Neurobiol. Aging, 35, 858, 10.1016/j.neurobiolaging.2013.09.034
Dexter, 1989, Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease, J. Neurochem., 52, 1830, 10.1111/j.1471-4159.1989.tb07264.x
Loeffler, 1996, Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders, Brain Res., 738, 265, 10.1016/S0006-8993(96)00782-2
Ayton, 2013, Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease, Ann. Neurol., 73, 554, 10.1002/ana.23817
Popescu, 2009, Iron, copper, and zinc distribution of the cerebellum, Cerebellum, 8, 74, 10.1007/s12311-008-0091-3
Uitti, 1989, Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains, Can. J. Neurol. Sci., 16, 310, 10.1017/S0317167100029140
Ayton, 2012, Ceruloplasmin dysfunction and therapeutic potential for parkinson disease, Ann. Neurol., 73, 554, 10.1002/ana.23817
Wypijewska, 2010, Iron and reactive oxygen species activity in parkinsonian substantia nigra, Parkinsonism Relat. Disord., 16, 329, 10.1016/j.parkreldis.2010.02.007
Zlatic, 2015, Molecular basis of neurodegeneration and neurodevelopmental defects in Menkes disease, Neurobiol. Dis., 81, 154, 10.1016/j.nbd.2014.12.024
Miotto, 2014, Site-specific copper-catalyzed oxidation of alpha-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease, Inorg. Chem., 53, 4350, 10.1021/ic4031377
Binolfi, 2010, Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein, Inorg. Chem., 49, 10668, 10.1021/ic1016752
Wright, 2009, Unique copper-induced oligomers mediate alpha-synuclein toxicity, FASEB J., 23, 2384, 10.1096/fj.09-130039
Santner, 2010, Metalloproteomics and metal toxicology of alpha-synuclein, Metallomics, 2, 378, 10.1039/b926659c
Rose, 2011, Mechanism of copper(II)-induced misfolding of Parkinson's disease protein, Sci. Rep., 1, 11, 10.1038/srep00011
Halliday, 2005, Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease, Brain, 128, 2654, 10.1093/brain/awh584
Tavassoly, 2014, Cu(II) and dopamine bind to alpha-synuclein and cause large conformational changes, FEBS J., 281, 2738, 10.1111/febs.12817
Ha, 2014, Dopamine and Cu+/2+ can induce oligomerization of alpha-synuclein in the absence of oxygen: two types of oligomerization mechanisms for alpha-synuclein and related cell toxicity studies, J. Neurosci. Res., 92, 359, 10.1002/jnr.23323
Wang, 2010, Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity, J. Neurochem., 113, 704, 10.1111/j.1471-4159.2010.06638.x
Wilhelm, 2014, Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins, Science, 344, 1023, 10.1126/science.1252884
Moriarty, 2014, A revised picture of the Cu(II)-alpha-synuclein complex: the role of N-terminal acetylation, Biochemistry, 53, 2815, 10.1021/bi5003025
Miotto, 2015, Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding, J. Am. Chem. Soc., 137, 6444, 10.1021/jacs.5b01911
Miller, 1987, Milk and casein-based diets for the study of brain catecholamines in copper-deficient rats, J. Nutr., 117, 1890, 10.1093/jn/117.11.1890
Prohaska, 1975, Copper deficiency in the developing rat brain: evidence for abnormal mitochondria, J. Neurochem., 25, 221, 10.1111/j.1471-4159.1975.tb06956.x
Yajima, 1979, Neuronal degeneration in the brain of the brindled mouse. II. Ultrastructure of neuronal inclusions in the cerebral cortex, Acta Neuropathol., 48, 133, 10.1007/BF00691154
Prohaska, 1982, Effect of dietary or genetic copper deficiency on brain catecholamines, trace metals and enzymes in mice and rats, J. Nutr., 112, 1706, 10.1093/jn/112.9.1706
Rossi, 2001, Increased susceptibility of copper-deficient neuroblastoma cells to oxidative stress-mediated apoptosis, Free Radic. Biol. Med., 30, 1177, 10.1016/S0891-5849(01)00533-0
Lombardo, 2003, Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells, Cell. Mol. Life Sci., 60, 1733, 10.1007/s00018-003-3153-1
Valentine, 2005, Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis, Annu. Rev. Biochem., 74, 563, 10.1146/annurev.biochem.72.121801.161647
Girotto, 2014, DJ-1 is a copper chaperone acting on SOD1 activation, J. Biol. Chem., 289, 10887, 10.1074/jbc.M113.535112
Polazzi, 2013, Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity, Neuro-Signals, 21, 112, 10.1159/000337115
Torsdottir, 2006, Ceruloplasmin and superoxide dismutase (SOD1) in Parkinson's disease: a follow-up study, J. Neurol. Sci., 241, 53, 10.1016/j.jns.2005.10.015
Boll, 2008, Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases, Neurochem. Res., 33, 1717, 10.1007/s11064-008-9610-3
Alcaraz-Zubeldia, 2001, Neuroprotective effect of acute and chronic administration of copper (II) sulfate against MPP+ neurotoxicity in mice, Neurochem. Res., 26, 59, 10.1023/A:1007680616056
Rubio-Osornio, 2009, Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats, Neurochem. Int., 54, 447, 10.1016/j.neuint.2009.01.019
Przedborski, 1992, Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity, J. Neurosci., 12, 1658, 10.1523/JNEUROSCI.12-05-01658.1992
Miller, 1991, Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium, J. Neurochem., 57, 541, 10.1111/j.1471-4159.1991.tb03784.x
Furukawa, 2006, Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis, Antioxid. Redox Signal., 8, 847, 10.1089/ars.2006.8.847
Lamb, 2001, Heterodimeric structure of superoxide dismutase in complex with its metallochaperone, Nat. Struct. Biol., 8, 751, 10.1038/nsb0901-751
Schmidt, 1999, Multiple protein domains contribute to the action of the copper chaperone for superoxide dismutase, J. Biol. Chem., 274, 23719, 10.1074/jbc.274.34.23719
Wang, 2011, DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection, Ann. Neurol., 70, 591, 10.1002/ana.22514
Bandopadhyay, 2004, The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease, Brain, 127, 420, 10.1093/brain/awh054
McCarthy, 2004, Prana Biotechnology, Limited: metal attenuation in the treatment of neurodegenerative disease, Chem. Biol., 11, 1473, 10.1016/j.chembiol.2004.12.003
Litwin, 2013, Wilson disease–factors affecting clinical presentation, Neurol. Neurochir. Pol., 47, 161, 10.5114/ninp.2013.34397
Lewis, 2001, Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): an agent for radiotherapy, Proc. Natl. Acad. Sci. U.S.A., 98, 1206, 10.1073/pnas.98.3.1206
Hung, 2012, The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease, J. Exp. Med., 209, 837, 10.1084/jem.20112285
Bica, 2014, Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation, PLoS One, 9, e90070, 10.1371/journal.pone.0090070
Ikawa, 2011, Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET, Nucl. Med. Biol., 38, 945, 10.1016/j.nucmedbio.2011.02.016
Ritchie, 2003, Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial, Arch. Neurol., 60, 1685, 10.1001/archneur.60.12.1685
Lannfelt, 2008, Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial, Lancet Neurol., 7, 779, 10.1016/S1474-4422(08)70167-4
Faux, 2010, PBT2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses, J. Alzheimers Dis., 20, 509, 10.3233/JAD-2010-1390
Price, 2008, Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide, Int. J. Biochem. Cell Biol., 40, 1901, 10.1016/j.biocel.2008.01.033
White, 2006, Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity, J. Biol. Chem., 281, 17670, 10.1074/jbc.M602487200
Crouch, 2011, The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity, J. Neurochem., 119, 220, 10.1111/j.1471-4159.2011.07402.x
Huntington Study Group Reach2HD Investigators, 2015, Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial, Lancet Neurol., 14, 39, 10.1016/S1474-4422(14)70262-5
Wilkins, 2009, Clioquinol protects against cell death in Parkinson's disease models in vivo and in vitro, Basal Ganglia IX, 431, 10.1007/978-1-4419-0340-2
Kaur, 2003, Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease, Neuron, 37, 899, 10.1016/S0896-6273(03)00126-0
Osherovich, 2012, Buddy system for orphan disease, SciBX, 5, 1020
Finkelstein, 2013, PBT434, a novel 8-hydroxyquinazolinone, preserves nigro-striatal circuitry, improves motor performance and inhibits alpha syncuclein accumulation in animal models of Parkinson's disease by modulation of iron homeostasis, Movement Disorders, Abstract Supplement, Abstracts of the 17th International Congress of Parkinson's Disease and Movement Disorders, Sydney, Australia, 16–20 June 2013, 28, S369