Control of Regulatory T Cell Development by the Transcription Factor Foxp3

American Association for the Advancement of Science (AAAS) - Tập 299 Số 5609 - Trang 1057-1061 - 2003
Shohei Hori1, Takashi Nomura2, Shimon Sakaguchi2,1
1Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230–0045, Japan.
2Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606–8507, Japan.

Tóm tắt

Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3 , which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4 + regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4 + regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.

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Tài liệu tham khảo

10.1126/science.280.5361.243

10.1016/S0092-8674(00)80856-9

10.1038/ni0901-816

10.1034/j.1600-065X.2001.1820107.x

10.1038/nri821

Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M., J. Immunol. 155, 1151 (1995).

Itoh M., et al., J. Immunol. 162, 5317 (1999).

10.1084/jem.184.2.387

Suri-Payer E., Amar A. Z., Thornton A. M., Shevach E. M., J. Immunol. 160, 1212 (1998).

10.1084/jem.192.2.295

10.1084/jem.194.9.1349

10.1136/jmg.39.8.537

Godfrey V. L., Wilkinson J. E., Russell L. B., Am. J. Pathol. 138, 1379 (1991).

Blair P. J., et al., J. Immunol. 153, 3764 (1994).

Clark L. B., et al., J. Immunol. 162, 2546 (1999).

10.1002/1521-4141(200101)31:1<196::AID-IMMU196>3.0.CO;2-9

10.1038/83784

10.1172/JCI11679

10.1038/83707

10.1038/83713

Materials and methods are available as supporting material on Science Online.

10.4049/jimmunol.165.6.3105

10.4049/jimmunol.166.5.3008

10.1084/jem.192.2.303

10.1016/S1074-7613(00)80195-8

10.1038/ni759

10.1016/S1074-7613(02)00280-7

10.1073/pnas.192162899

10.1093/intimm/10.12.1969

10.1084/jem.188.2.287

10.1006/jaut.2000.0473

S. Hori T. Nomura S. Sakaguchi unpublished data.

We thank K. J. Wood Z. Fehervari and T. Takahashi for critically reading the manuscript; W. S. Pear and T. Kitamura for reagents; and T. Matsushita for histology. Supported by grants-in-aid from the Ministry of Education Sports and Culture the Ministry of Human Welfare and the Organization for Pharmaceutical Safety and Research of Japan.

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American Association for the Advancement of Science (AAAS)

Tập 299 Số 5609

1057-1061

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