Marion Criaud1,2,3,4,5, Leigh Christopher2,3,4, Philippe Boulinguez1,6,5, Bénédicte Ballanger1,6,5, Anthony E. Lang3, Sang S. Cho2,3,4, Sylvain Houle4, Antonio P. Strafella2,3,4
1Centre De Neuroscience Cognitive CNRS, UMR5229 Bron France
2Division of Brain, Imaging and Behaviour – Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada
3Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto Ontario Canada
4Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
5Université Lyon 1, Villeurbanne, France
6Université De Lyon Lyon F‐69622 France
Tóm tắt
AbstractThe insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson's disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate‐based quantitative meta‐analysis approach, the activation likelihood estimation. A total of 132 insular foci were selected from 96 published experiments comprising the five functional categories: cognition, affective/behavioral symptoms, bodily awareness/autonomic function, sensorimotor function, and nonspecific resting functional changes associated with the disease. We found a significant convergence of activation maxima related to PD in different insular regions including anterior and posterior regions bilaterally. This study provides evidence of an important functional distribution of different domains within the insular cortex in PD, particularly in relation to nonmotor aspects, with an influence of medication effect. Hum Brain Mapp 37:1375‐1392, 2016. © 2016 Wiley Periodicals, Inc.
