Contraction and increase in tissue calcium content induced by maitotoxin, the most potent known marine toxin, in intestinal smooth muscle

British Journal of Pharmacology - Tập 79 Số 1 - Trang 3-5 - 1983
Yasushi Ohizumi1, Takeshi Yasumoto2,3
1Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194.
2Faculty of Agriculture, Tohoku University, Sendai, 980 Japan
3Mitsubishi-Kasei Institute of Life Sciences, Machida, Tokyo 194

Tóm tắt

Maitotoxin (MTX), the most potent known marine toxin, isolated from toxic dinoflagellates and poisonous fish, caused a dose‐dependent contraction of the guinea‐pig isolated ileum and taenia caeci at concentrations of 100 pg to 30 ng/ml. These contractile responses to MTX (3 ng/ml) in both tissues were abolished by incubation in Ca2+‐free solution and were markedly inhibited by treatment with methoxyverapamil (D600), but were not affected by tetrodotoxin and atropine. Furthermore, MTX markedly elevated tissue Ca2+ content of the taenia caeci. These results suggest that MTX activates Ca2+ channels in the smooth muscle membrane of both tissues to increase Ca2+ influx and thus induces contractions.

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Tài liệu tham khảo

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British Journal of Pharmacology

Tập 79 Số 1

3-5

Thông tin tác giả