Mối quan hệ giữa việc tiêu thụ thịt đỏ và bánh mì nguyên cám với các biomarker liên quan đến béo phì, viêm, chuyển hóa glucose và căng thẳng oxy hóa

Springer Science and Business Media LLC - Tập 52 - Trang 337-345 - 2012
Jukka Montonen1, Heiner Boeing1, Andreas Fritsche2, Erwin Schleicher2, Hans-Georg Joost3, Matthias B. Schulze4, Annika Steffen1, Tobias Pischon1,5
1Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
2Department of Internal Medicine IV, University of Tuebingen, Tübingen, Germany
3Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
4Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
5Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany

Tóm tắt

Nghiên cứu này nhằm xem xét mối liên hệ giữa việc tiêu thụ thịt đỏ và bánh mì nguyên cám với các mức biomarker trong huyết tương liên quan đến chuyển hóa glucose, căng thẳng oxy hóa, viêm nhiễm và béo phì. Nghiên cứu cắt ngang của chúng tôi dựa trên 2,198 nam và nữ được chọn làm tiểu nhóm cho cuộc điều tra các yếu tố sinh học dự đoán bệnh tiểu đường và bệnh tim mạch từ nghiên cứu Điều tra Tiềm năng Châu Âu về Ung thư và Dinh Dưỡng-Potsdam. Các mức độ glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase, alanine-aminotransferase, fetuin-A, HDL-cholesterol và triglycerides được đo từ các mẫu máu ngẫu nhiên. Dữ liệu về chế độ ăn uống và lối sống được đánh giá thông qua bảng câu hỏi, và dữ liệu nhân trắc được đo lường. Sau khi điều chỉnh đa biến, việc tiêu thụ cao hơn bánh mì nguyên cám có sự liên kết đáng kể (P trend <0.05) với mức độ GGT, ALT và hs-CRP thấp hơn, trong khi việc tiêu thụ cao hơn thịt đỏ có liên kết đáng kể với mức độ GGT và hs-CRP cao hơn sau khi điều chỉnh cho các yếu tố gây nhiễu liên quan đến lối sống và chế độ ăn uống. Việc điều chỉnh thêm đối với chỉ số khối cơ thể (BMI) và chu vi vòng eo đã làm giảm sự liên kết giữa thịt đỏ và hs-CRP (P = 0.19). Kết quả của nghiên cứu này cho thấy việc tiêu thụ bánh mì nguyên cám cao liên quan đến mức độ GGT, ALT và hs-CRP thấp hơn, trong khi việc tiêu thụ thịt đỏ cao có liên quan đến các mức độ GGT và hs-CRP trong huyết tương cao hơn.

Từ khóa

#thịt đỏ #bánh mì nguyên cám #biomarker #chuyển hóa glucose #viêm #béo phì #căng thẳng oxy hóa

Tài liệu tham khảo

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