Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 2 - Trang 48-59 - 2016
Larry Alphs1, H. Robert Brashear2, Phillip Chappell3, Yeates Conwell4, Sarah Dubrava3, Ni A. Khin5,6, Nicholas Kozauer7, Dean M. Hartley8, David S. Miller9, Rachel J. Schindler10, Eric R. Siemers11, Michelle Stewart3, Kristine Yaffe12
1Janssen Scientific Affairs, LLC, Titusville, NJ, USA
2Janssen Alzheimer Immunotherapy Research & Development, LLC, South San Francisco, CA, USA
3Pfizer, Groton, CT, USA
4University of Rochester, Rochester, NY USA
5Division of Psychiatry Products, Food and Drug Administration, Silver Spring, MD, USA
6Division of Clinical Compliance Evaluation, FDA, Silver Spring, MD, USA
7Division of Neurology Products, Food and Drug Administration, Silver Spring, MD, USA
8Alzheimer's Association Chicago IL USA
9Bracket, Wayne, PA, USA
10Pfizer Inc., New York, NY, USA
11Eli Lilly and Company, Inc., Indianapolis, IN, USA
12University of California, San Francisco, CA, USA

Tóm tắt

AbstractIntroductionBetter understanding of suicide risk and its management in older adults with cognitive impairment and/or dementia remain significant unmet public health needs. Urgency to address them derives from concern that CNS treatments for dementia may impact suicide risk. Regulatory guidances requiring assessment of emergent suicidal ideation and behavior (SI/SB) at every clinical trial visit emphasize the need for understanding their prevalence.MethodsThe literature regarding SI/SB in older persons with cognitive impairment or dementia was reviewed by an Alzheimer's Association Taskforce with emphasis on epidemiology, classification, assessment, and regulatory requirements.ResultsGaps in our knowledge were identified, challenges discussed and recommendations for future work provided.DiscussionCurrently available SI/SB data from geriatric persons with dementia do not provide adequate understanding of its epidemiology, identification, assessment, or management. The growing public health burden of this population requires greater attention from clinicians and researchers on tactics and assessment tools to meet these needs.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 2

48-59

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