R.R. Angell1, Allan Templeton2, Ioannis E. Messinis2
1MRC Unit of Reproductive Biology and
2Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, dinburgh
Tóm tắt
Polyspermy occurs with a frequency of about 12% under some hormonal regimens currently being used for in vitro fertilization and embryo transfer. Oocytes with three pronuclei usually show normal cleavage and are morphologically indistinguishable from embryos produced by normal fertilization. Chromosome studies and DNA measurements on dispermic embryos show that about one-half are triploid, the others having either a normal diploid chromosome complement or a severely depleted chromosome complement. The evidence suggests that these errors must arise at the first mitotic division of the oocyte. Aberrant spindle formation is implicated.
