Computerized Morphometric Study of Thyroid Follicular Carcinoma in Correlation with Known Prognostic Factors

The Kaohsiung Journal of Medical Sciences - Tập 21 - Trang 65-69 - 2005
Sheng-Lan Wang1, Sheau-Fang Yang1, Chee-Yin Chai1
1Department of Pathology, Kaohsiung, Taiwan

Tóm tắt

This study investigates the correlation between computer‐assisted nuclear morphometry and known prognostic factors in thyroid follicular carcinoma. Thirty‐six patients with thyroid follicular carcinoma who underwent surgery between 1991 and 2001 were grouped according to sex, age, size of the primary lesion, the presence of vascular invasion, and metastases. Four nuclear parameters were measured and analyzed: mean nuclear area, mean nuclear perimeter, largest to smallest diameter ratio of the nuclei, and coefficient of variation of the nuclear area. Our results indicated that none of the chosen nuclear variables were significantly correlated with the prognostic factors studied. In conclusion, nuclear morphometry does not seem to correlate with known prognostic factors and cannot serve as an additional predicting factor for biologic behavior.

Tài liệu tham khảo

10.1002/(SICI)1097-0142(19980425)84:2<115::AID-CNCR8>3.0.CO;2-O Ozer E, 2001, Prognostic significance of nuclear morphometry in superficial bladder cancer, Anal Quant Cytol Histol, 23, 251 Ikeguchi M, 1999, Computerized nuclear morphometry is a useful technique for evaluating the high metastatic potential of colorectal adenocarcinoma, Cancer, 86, 944, 10.1002/(SICI)1097-0142(19991115)86:10<1944::AID-CNCR10>3.0.CO;2-2 10.1016/S0090-4295(02)01530-3 Rajesh L, 2004, Morphometric image analysis of follicular lesions of the thyroid, Anal Quant Cytol Histol, 26, 117 Kavantzas N, 2002, Computerized nuclear morphometry and quantitation of angiogenesis in thyroid neoplasms, J Exp Clin Cancer Res, 21, 247 10.1002/1097-0142(20011001)92:7<1818::AID-CNCR1698>3.0.CO;2-U Tseleni‐Balafouta S, 2000, Computerized morphometric study on fine needle aspirates of cellular follicular lesions of the thyroid, Anal Quant Cytol Histol, 22, 323 10.1089/105072501753211000 10.1093/ajcp/94.5.527 10.1016/S0025-6196(12)61170-7 Shaha AR, 1995, Prognostic factors and risk group analysis in follicular carcinoma of the thyroid, Surgery, 18, 1131, 10.1016/S0039-6060(05)80124-2 10.1111/j.1365-2559.2004.01948.x 10.1038/sj.bjc.6600617 Bol MG, 2003, Prognostic value of proliferative activity and nuclear morphometry for progression in TaT1 urothelial cell carcinomas of the urinary bladder, Urology, 60, 1124, 10.1016/S0090-4295(02)01906-4 Tseleni S, 1997, Findings of computerized nuclear morphometry of papillary thyroid carcinoma in correlation with known prognostic factors, J Exp Clin Cancer Res, 16, 401 10.1016/0046-8177(89)90126-3 Palestini N, 1994, Prognostic value of nuclear morphometry in follicular carcinoma of the thyroid gland, Ann Ital Chir, 65, 69
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The Kaohsiung Journal of Medical Sciences

Tập 21

65-69

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