Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

Medicinal Research Reviews - Tập 34 Số 2 - Trang 340-437 - 2014
Ling Zhang1, Xin-Mei Peng1, Guri L. V. Damu1, Rong‐Xia Geng1, Cheng‐He Zhou1
1Laboratory of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People’s Republic of China

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Hill, 2009, Marine natural products, Annu Rep Prog Chem Sect B, 105, 150, 10.1039/b822053k

Forte, 2009, A submarine journey: The pyrrole-imidazole alkaloids, Mar Drugs, 7, 705, 10.3390/md7040705

Jin, 2011, Muscarine, imidazole, oxazole, and thiazole alkaloids, Nat Prod Rep, 28, 1143, 10.1039/c0np00074d

Gao, 2002, Efficient imidazolium catalysts for the benzoin condensation, J Chem Res, 2002, 262, 10.3184/030823402103172130

Jiang, 2006, Chiral imidazole metalloenzyme models: Synthesis and enantioselective hydrolysis for a-amino acid esters, J Mol Catal A: Chem, 260, 288, 10.1016/j.molcata.2006.07.034

Molina, 2012, Imidazole derivatives: A comprehensive survey of their recognition properties, Org Biomol Chem, 10, 1711, 10.1039/c2ob06808g

Aleksandrova, 2011, Properties of haloimidazoles, Chem Heterocycl Compd, 47, 261, 10.1007/s10593-011-0754-8

Narasimhan, 2011, Biological importance of imidazole nucleus in the new millennium, Med Chem Res, 20, 1119, 10.1007/s00044-010-9472-5

Shalini, 2010, Imidazole and its biological activities: A review, Chem Sinica, 1, 36

Bhatnagar, 2011, A review on “Imidazoles”: Their chemistry and pharmacological potentials, Int J PharmTech Res, 3, 268

Boiani, 2005, Imidazole and benzimidazole derivatives as chemotherapeutic agents, Mini Rev Med Chem, 5, 409, 10.2174/1389557053544047

Zhou, 2012, Recent researches in triazole compounds as medicinal drugs, Curr Med Chem, 19, 239, 10.2174/092986712803414213

Zhang, 2014, Current developments in the syntheses of 1,2,4-triazole compounds, Curr Org Chem

Lu, 2012, Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2, Eur J Med Chem, 49, 164, 10.1016/j.ejmech.2012.01.007

Keter, 2012, Perspective: The potential of pyrazole-based compounds in medicine, Biometals, 25, 9, 10.1007/s10534-011-9496-4

Liaras, 2011, Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation, Bioorg Med Chem, 19, 3135, 10.1016/j.bmc.2011.04.007

Varadaraji, 2010, Synthesis and evaluation of a series of 1-substituted tetrazole derivatives as antimicrobial agents, Org Commun, 3, 45

Pattabiraman, 2011, Rethinking amide bond synthesis, Nature, 480, 471, 10.1038/nature10702

Zhou, 2009, Review on supermolecules as chemical drugs, Sci China Ser B, 52, 415, 10.1007/s11426-009-0103-2

Zhou, 2010, Recent researches in metal supramolecular complexes as anticancer agents, Anticancer Agents Med Chem, 10, 371, 10.2174/1871520611009050371

Steinman, 2012, Zoledronic acid effectiveness against breast cancer metastases-A role for estrogen in the microenvironment?, Breast Cancer Res, 14, 213, 10.1186/bcr3223

Ashley, 2010, Antifungal Therapy, 199

Mishra, 2012, Imidazole as an anti-epileptic: An overview, Med Chem Res, 21, 3929, 10.1007/s00044-012-9972-6

Burnier, 2011, Pharmacokinetic evaluation of losartan, Expert Opin Drug Metab Toxicol, 7, 643, 10.1517/17425255.2011.570333

Carrillo-Munoz, 2005, Sertaconazole: Updated review of a topical antifungal agent, Expert Rev Anti Infect Ther, 3, 333, 10.1586/14787210.3.3.333

Fothergill, 2006, Miconazole: A historical perspective, Expert Rev Anti Infect Ther, 4, 171, 10.1586/14787210.4.2.171

Natarajan, 2005, P38 MAP kinase inhibitors: Evolution of imidazole-based and pyrido-pyrimidin-2-one lead classes, Curr Top Med Chem, 5, 987, 10.2174/1568026054985876

De Luca, 2006, Naturally occurring and synthetic imidazoles: Their chemistry and their biological activities, Curr Med Chem, 13, 1

Kumar, 2010, Review of imidazole heterocyclic ring containing compounds with their biological activity, Pharmacophore, 1, 167

Grasso, 2012, The mutational landscape of lethal castration-resistant prostate cancer, Nature, 487, 239, 10.1038/nature11125

Cragg, 2009, Impact of natural products on developing new anti-cancer agents, Chem Rev, 109, 3012, 10.1021/cr900019j

Kapuriya, 2011, Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents, Bioorg Med Chem, 19, 471, 10.1016/j.bmc.2010.11.005

Tang, 2012, Synthesis and characterization of thiophene-derived amido bis-nitrogen mustard and its antimicrobial and anticancer activities, Chin J Chem, 30, 1831, 10.1002/cjoc.201100668

Yu, 2007, Recent progress of the porphyrin-based anticancer drugs, Chem Res Appl, 19, 1296

Li, 2007, Synthesis and anticancer activities of porphyrin induced anticancer drugs, Chin Chem Lett, 18, 1331, 10.1016/j.cclet.2007.09.012

Zhu, 2011, Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy, Chem Commun, 47, 10311, 10.1039/c1cc13328d

Wang, 2011, Recent advances in the researches of triazole compounds as medicinal drugs, Sci Sin Chem, 41, 1429, 10.1360/032010-843

Meng, 2008, Advances in the research of benzimidazole compounds as enzyme inhibitors, Chin J Biochem Pharm, 29, 422

Zhou, 2009, Research in supermolecular chemical drugs, Sci China Ser B, 39, 208

Baroniya, 2010, Recent advancement in imidazole as anticancer agents: A review, Pharm Sinica, 1, 172

Cai, 2009, Advance in research of imidazoles as anti-tumor agents, Chin J New Drugs, 18, 598

Zhou, 2001, Synthesis and anticancer activity of novel chiral glucose derived bis-imidazoles and their analogs, Carbohydr Res, 333, 313, 10.1016/S0008-6215(01)00154-9

Holleran, 2010, Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776, J Pharm Biomed Anal, 52, 714, 10.1016/j.jpba.2010.02.020

Pommier, 2009, DNA topoisomerase I inhibitors: Chemistry, biology, and interfacial inhibition, Chem Rev, 109, 2894, 10.1021/cr900097c

Li, 2010, Cytotoxicity and Topo I targeting activity of substituted 10-nitrogenous heterocyclic aromatic group derivatives of SN-38, Eur J Med Chem, 45, 3200, 10.1016/j.ejmech.2010.03.013

Li, 2009, Synthesis and antitumor activity of novel 20s-camptothecin analogues, Bioorg Med Chem Lett, 19, 513, 10.1016/j.bmcl.2008.11.031

Beretta, 2012, Targeting DNA topoisomerase I with non-camptothecin poisons, Curr Med Chem, 19, 1238, 10.2174/092986712799320529

Pommier, 2009, The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: Update and perspectives, Mol Cancer Ther, 8, 1001, 10.1158/1535-7163.MCT-08-0706

Cinelli, 2010, The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode, Bioorg Med Chem, 18, 5535, 10.1016/j.bmc.2010.06.040

Morrell, 2006, Synthesis of benz[d]indeno[1,2-b] pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors, Bioorg Med Chem Lett, 16, 1846, 10.1016/j.bmcl.2006.01.008

Kiselev, 2010, Design, synthesis, and evaluation of dibenzo[c,h][1,6] naphthyridines as topoisomerase I inhibitors and potential anticancer agents, J Med Chem, 53, 8716, 10.1021/jm101048k

Song, 2010, Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors, J Med Chem, 53, 1979, 10.1021/jm901649x

Sondhi, 2010, Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives, Eur J Med Chem, 45, 555, 10.1016/j.ejmech.2009.10.042

Shang, 2012, Synthesis and biological evaluation of 4a/4b-imidazolyl podophyllotoxin analogues as antitumor agents, Arch Pharm, 345, 43, 10.1002/ardp.201100094

Shinohara, 2010, Anticancer activities of alkylating pyrroles-imidazole polyamides with specific sequence recognition, Anticancer Drugs, 21, 228, 10.1097/CAD.0b013e328334d8f9

Franks, 2010, Targeting the ICB2 site of the topoisomerase II a promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide, Bioorg Med Chem, 18, 5553, 10.1016/j.bmc.2010.06.041

Bhattacharyya, 2008, Antimitotic activity of colchicine and the structural basis for its interaction with tubulin, Med Res Rev, 28, 155, 10.1002/med.20097

Arora, 2009, Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity, Cancer Res, 69, 1910, 10.1158/0008-5472.CAN-08-0877

Bonezzi, 2009, Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles, J Med Chem, 52, 7906, 10.1021/jm900968s

Ciupa, 2011, Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives, MedChemComm, 2, 1011, 10.1039/c1md00155h

Shan, 2011, Developments of combretastatin A-4 derivatives as anticancer agents, Curr Med Chem, 18, 523, 10.2174/092986711794480221

Chaudhary, 2007, Combretastatin A-4 analogs as anticancer agents, Mini Rev Med Chem, 7, 1186, 10.2174/138955707782795647

Lu, 2009, Discovery of 4-substituted methoxybenzoylaryl-thiazole as novel anticancer agents: Synthesis, biological evaluation, and structure-activity relationships, J Med Chem, 52, 1701, 10.1021/jm801449a

Bellina, 2006, Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin, Bioorg Med Chem Lett, 16, 5757, 10.1016/j.bmcl.2006.08.087

Chen, 2012, Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents, J Med Chem, 55, 7285, 10.1021/jm300564b

Beale, 2010, Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4, MedChemComm, 1, 202, 10.1039/c0md00095g

Biersack, 2011, Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4- methoxyphenyl)-5-(halophenyl)-imidazoles, Bioorg Med Chem Lett, 21, 6270, 10.1016/j.bmcl.2011.09.005

Bonezzi, 2009, Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles, J Med Chem, 52, 7906, 10.1021/jm900968s

Chen, 2011, Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization, Bioorg Med Chem, 19, 4782, 10.1016/j.bmc.2011.06.084

Chen, 2010, Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents, J Med Chem, 53, 7414, 10.1021/jm100884b

La Barbera, 2009, The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells, Anticancer Drugs, 20, 425, 10.1097/CAD.0b013e32832ae55f

Bielawski, 2009, Synthesis and cytotoxic activity of novel amidine analogues of bis(2-chloroethyl) amine, Arch Pharm, 342, 484, 10.1002/ardp.200800231

Li, 2010, Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents, J Med Chem, 53, 2409, 10.1021/jm901501s

Cui, 2012, Recent advances in application of thiazole compounds, Sci Sin Chim, 42, 1105

Li, 2012, Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents, Invest New Drugs, 30, 164, 10.1007/s10637-010-9547-7

Sadek, 2011, Imidazole-substituted drugs and tendency for inhibition of cytochrome P450 isoenzymes: A review, Pharma Chem, 3, 410

Nabholtz, 2009, Comparative review of anastrozole, letrozole and exemestane in the management of early breast cancer, Expert Opin Pharmacother, 10, 1435, 10.1517/14656560902953738

Narayana, 2012, Molecular modeling evaluation of non-steroidal aromatase inhibitors, Chem Biol Drug Des, 79, 674, 10.1111/j.1747-0285.2011.01277.x

Bansal, 2013, Synthesis of imidazole-derived steroidal hybrids as potent aromatase inhibitors, Med Chem Res, 22, 692, 10.1007/s00044-012-0059-1

Roy, 2010, Classical and 3D-QSAR studies of cytochrome 17 inhibitor imidazole-substituted biphenyls, Mol Simul, 36, 311, 10.1080/08927020903426493

Yin, 2012, Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of cushing's syndrome, J Med Chem, 55, 6629, 10.1021/jm3003872

Gomaa, 2012, Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates, Bioorg Med Chem, 20, 6080, 10.1016/j.bmc.2012.08.044

Doiron, 2011, Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors, Eur J Med Chem, 46, 4010, 10.1016/j.ejmech.2011.05.074

Nagar, 2009, Pharmacophore searching of benzofuran derivatives for selective CYP19 aromatase inhibition, Lett Drug Des Discov, 6, 38, 10.2174/157018009787158607

Pautus, 2009, Design and synthesis of substituted imidazole and triazole N-phenylbenzo[d]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26, J Enzyme Inhib Med Chem, 24, 487, 10.1080/14756360802218334

Aboraia, 2010, Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl) arylamides, Bioorg Med Chem, 18, 4939, 10.1016/j.bmc.2010.06.011

Ahmed, 2009, Synthesis and biochemical evaluation of a range of 2-, 3- and 4-substituted derivatives of benzyl imidazole-based compounds as probes of the active site of 17a-hydroxylase/17,20-Lyase (P45017a), Lett Drug Des Discov, 6, 524, 10.2174/157018009789108295

Hu, 2010, The role of fluorine substitution in biphenyl methylene imidazole-type CYP17 inhibitors for the treatment of prostate carcinoma, ChemMedChem, 5, 899, 10.1002/cmdc.201000065

Kaku, 2011, 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors, Bioorg Med Chem, 19, 2428, 10.1016/j.bmc.2011.02.009

Owen, 2010, Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17a-hydroxylase/17,20-lyase (P45017a) derived from rat testicular microsomes, Bioorg Med Chem Lett, 20, 5345, 10.1016/j.bmcl.2010.02.100

Ahmed, 2009, Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17a-hydroxylase/17,20-lyase (P-45017a), Bioorg Med Chem Lett, 19, 4698, 10.1016/j.bmcl.2009.06.070

Gomaa, 2011, Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): Synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates, J Med Chem, 54, 2778, 10.1021/jm101583w

Bansal, 2011, Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy, Med Chem Res, 20, 661, 10.1007/s00044-010-9368-4

Peng, 2013, Current developments of coumarin compounds in medicinal chemistry, Curr Pharm Des, 19, 3884, 10.2174/1381612811319210013

Stefanachi, 2011, Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase, J Med Chem, 54, 1613, 10.1021/jm101120u

Gobbi, 2010, Novel highly potent and selective nonsteroidal aromatase inhibitors: Synthesis, biological evaluation and structure-activity relationships investigation, J Med Chem, 53, 5347, 10.1021/jm100319h

Abadi, 2012, Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors, MedChemComm, 3, 663, 10.1039/c2md20072d

Brendel, 2011, Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors, Cancer Chemother Pharmacol, 68, 53, 10.1007/s00280-010-1423-9

Lee, 2010, Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines, Bioorg Med Chem Lett, 20, 1573, 10.1016/j.bmcl.2010.01.064

Rajitha, 2011, Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as a new class of anti-cancer agents, Eur J Med Chem, 46, 4887, 10.1016/j.ejmech.2011.07.045

Yu, 2010, 1,4-Dihydropyrazolo[4,3-d] imidazole phenyl derivatives: A novel type II Raf kinase inhibitors, Bioorg Med Chem Lett, 20, 3805, 10.1016/j.bmcl.2010.04.039

Niculescu-Duvaz, 2010, Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds, Bioorg Med Chem, 18, 6934, 10.1016/j.bmc.2010.06.031

Dewang, 2010, Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-b type 1 receptor kinase inhibitors, Bioorg Med Chem Lett, 20, 4228, 10.1016/j.bmcl.2010.05.032

Inman, 2002, SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, J Mol Pharmacol, 62, 65, 10.1124/mol.62.1.65

Kim, 2009, Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-b type 1 receptor kinase inhibitors, Eur J Med Chem, 44, 568, 10.1016/j.ejmech.2008.03.024

Kim, 2010, Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and pyrazoles as transforming growth factor-b type 1 receptor kinase inhibitors, Bioorg Med Chem, 18, 4459, 10.1016/j.bmc.2010.04.071

Li, 2009, Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor b type 1 receptor (ALK5), Bioorg Med Chem Lett, 19, 4868, 10.1016/j.bmcl.2009.04.066

Ciayadi, 2011, 2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-b1 and activin A signaling, Bioorg Med Chem Lett, 21, 5642, 10.1016/j.bmcl.2010.12.120

Amada, 2012, Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-b type 1 receptor kinase, Bioorg Med Chem Lett, 22, 2024, 10.1016/j.bmcl.2012.01.066

Amada, 2012, 5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor- b type I receptor inhibitors, Bioorg Med Chem, 20, 7128, 10.1016/j.bmc.2012.09.066

Zhang, 2006, Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer, J Clin Pharmacol, 46, 1116, 10.1177/0091270006291034

Xie, 2009, Imidazole-containing farnesyltransferase inhibitors: 3D quantitative structure-activity relationships and molecular docking, J Comput Aided Mol Des, 23, 431, 10.1007/s10822-009-9278-z

Coudray, 2009, Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase, J Enzyme Inhib Med Chem, 24, 972, 10.1080/14756360802561196

Kerhervé, 2009, New asymmetric synthesis of protein farnesyltransferase inhibitors via palladium-catalyzed cross-coupling reactions of 2-iodo-imidazoles, Org Biomol Chem, 7, 2214, 10.1039/b902601k

Bolchi, 2011, Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase, Bioorg Med Chem Lett, 21, 5408, 10.1016/j.bmcl.2011.07.003

Asoh, 2009, Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors, Bioorg Med Chem Lett, 19, 1753, 10.1016/j.bmcl.2009.01.074

Fletcher, 2010, Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents, J Med Chem, 53, 6867, 10.1021/jm1001748

Zhu, 2010, Discovery of C-imidazole azaheptapyridine FPT inhibitors, Bioorg Med Chem Lett, 20, 1134, 10.1016/j.bmcl.2009.12.013

Duez, 2010, Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues, Bioorg Med Chem, 18, 543, 10.1016/j.bmc.2009.12.017

Chang, 2011, Recent advances in researches of triazole-based supramolecular chemistry and medicinal drugs, Chem J Chin Univ, 32, 1970

Luo, 1995, Design and synthesis of imidazolium cyclophane, Heterocycles, 41, 1421, 10.3987/COM-94-7019

Zhou, 1996, Convenient and efficient synthesis of imidazolium cyclophanes, Org Prep Proc Int, 28, 345, 10.1080/00304949609356541

Liu, 1999, First synthesis of estrogen-imidazolium cyclophanes, Synth Commun, 29, 2979, 10.1080/00397919908086472

Wei, 2005, An effective methodology to novel larger imidazolium cyclophanes, Lett Org Chem, 2, 507, 10.2174/1570178054640804

Gautier, 2012, Advances in metal-carbene complexes as potent anti-cancer agents, Metallomics, 4, 23, 10.1039/C1MT00123J

Ni, 2012, Osmium(VI) nitrido complexes bearing azole heterocycles: A new class of antitumor agents, Chem Sci, 3, 1582, 10.1039/c2sc01031c

Zhao, 2005, Metal complexes with aromatic N-containing ligands as potential agents in cancer treatment, Curr Med Chem Anticancer Agents, 5, 137, 10.2174/1568011053174873

Zhang, 2012, 5-Fluorouracil in combination with cisplatin alters the microRNA expression profile in the CNE nasopharyngeal carcinoma cell line, Mol Med Rep, 6, 303

Rademaker-Lakhai, 2004, A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent, Clin Cancer Res, 10, 3717, 10.1158/1078-0432.CCR-03-0746

Zhang, 2012, Recent progress and future potential for metal complexes as anticancer drugs targeting G-quadruplex DNA, Curr Med Chem, 19, 2957, 10.2174/092986712800672067

Klein, 2009, Platinum drug distribution in cancer cells and tumors, Chem Rev, 109, 4911, 10.1021/cr9001066

Büchel, 2011, En route to osmium analogues of KP1019: Synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[OsIVCl4(Hazole)2], Inorg Chem, 50, 7690, 10.1021/ic200728b

Büchel, 2009, [OsIVCl5(Hazole)]- complexes: Synthesis, structure, spectroscopic properties, and antiproliferative activity, Inorg Chem, 48, 10737, 10.1021/ic901671j

Ravera, 2011, Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands, J Inorg Biochem, 105, 400, 10.1016/j.jinorgbio.2010.12.002

Navarro, 2009, Synthesis, characterization, DNA interaction studies and anticancer activity of platinum-clotrimazole complexes, Transit Metal Chem, 34, 869, 10.1007/s11243-009-9276-y

Ravera, 2011, Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands, J Inorg Biochem, 105, 400, 10.1016/j.jinorgbio.2010.12.002

Hindi, 2009, The medicinal applications of imidazolium carbene-metal complexes, Chem Rev, 109, 3859, 10.1021/cr800500u

Sun, 2011, Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells, Chem Sci, 2, 728, 10.1039/c0sc00593b

Kennedy, 2011, Cationic ruthenium(III) maltolato-imidazole complexes-Synthesis, characterization, and antiproliferatory activity, Can J Chem, 89, 948, 10.1139/v11-074

Alessio, 2004, Ruthenium antimetastatic agents, Curr Top Med Chem, 4, 1525, 10.2174/1568026043387421

Suss-Fink, 2010, Arene ruthenium complexes as anticancer agents, Dalton Trans, 39, 1673, 10.1039/B916860P

Webb, 2011, Control of ligand-exchange processes and the oxidation state of the antimetastatic Ru(III) complex NAMI-A by interactions with human serum albumin, Dalton Trans, 40, 1322, 10.1039/c0dt01168a

Levina, 2009, Recent developments in ruthenium anticancer drugs, Metallomics, 1, 458, 10.1039/b904071d

Chen, 2009, A DFT study on the hydrolysis mechanism of the potential antitumor Ru(III) complex TzNAMI, THEOCHEM-J Mol Struct, 901, 137, 10.1016/j.theochem.2009.01.011

Vargiu, 2008, The hydrolysis mechanism of the anticancer ruthenium drugs NAMI-A and ICR investigated by DFT-PCM calculations, J Phys Chem B, 112, 4401, 10.1021/jp710078y

Tan, 2011, Synthesis, characterization, antiproliferative and anti-metastatic properties of two rutheniume DMSO complexes containing 2,2'-biimidazole, Eur J Med Chem, 46, 1555, 10.1016/j.ejmech.2011.01.074

Kennedy, 2010, Synthesis of ruthenium(II)-4,4′-biimidazole complexes and their potential anti-tumour activity, Can J Chem, 88, 886, 10.1139/V10-076

Zhang, 2011, Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities, Eur J Med Chem, 46, 4391, 10.1016/j.ejmech.2011.07.010

Quang, 2010, Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens, Chem Rev, 110, 6280, 10.1021/cr100154p

Felorzabihi, 2009, Up-conversion of 980 nm light into white light from sol-gel derived thin film made with new combinations of LaF3:Ln3+ nanoparticles, J Phys Chem B, 113, 2262, 10.1021/jp807637s

Filosa, 2009, Molecular modeling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors, Bioorg Med Chem, 17, 13, 10.1016/j.bmc.2008.11.024

Kilpin, 2012, Naphthalimide-tagged ruthenium-arene anticancer complexes: Combining coordination with intercalation, Organometallics, 31, 7031, 10.1021/om3007079

Renfrewa, 2011, Adding diversity to ruthenium(II) earene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains, J Organomet Chem, 696, 772, 10.1016/j.jorganchem.2010.09.067

Galassi, 2012, Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents, Dalton Trans, 41, 5307, 10.1039/c2dt11781a

Kunz, 2009, Imidazole-based phosphane gold(I) complexes as potential agents for cancer treatment: Synthesis, structural studies and antitumour activity, Dalton Trans, 37, 7741, 10.1039/b902748c

Schuh, 2012, Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents, J Med Chem, 55, 5518, 10.1021/jm300428v

Gabrielli, 2012, Neutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity, Polyhedron, 34, 188, 10.1016/j.poly.2011.12.026

Wetzel, 2011, Gold(I) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition, Dalton Trans, 40, 9212, 10.1039/c1dt10368g

Youngs, 2012, Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: A perspective, Dalton Trans, 41, 327, 10.1039/C1DT11100K

Monteiro, 2012, Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands, Dalton Trans, 41, 3720, 10.1039/c2dt12399a

Patil, 2010, Synthesis, cytotoxicity and antibacterial studies of novel symmetrically and nonsymmetrically 4-(methoxycarbonyl) benzyl-substituted N-heterocyclic carbene-silver acetate complexes, Helv Chim Acta, 93, 2347, 10.1002/hlca.201000310

Patil, 2011, Novel benzyl-substituted N-heterocyclic carbene-silver acetate complexes: Synthesis, cytotoxicity and antibacterial studies, Metallomics, 3, 74, 10.1039/C0MT00034E

Patil, 2010, Synthesis, cytotoxicity and antibacterial studies of symmetrically and non-symmetrically benzyl- or p-cyanobenzyl-substituted N-heterocyclic carbene-silver complexes, Appl Organomet Chem, 24, 781, 10.1002/aoc.1702

Tardito, 2009, Copper compounds in anticancer strategies, Curr Med Chem, 16, 1325, 10.2174/092986709787846532

Chen, 2009, Metal complexes, their cellular targets and potential for cancer therapy, Curr Pharm Des, 15, 777, 10.2174/138161209787582183

Wadas, 2007, Copper chelation chemistry and its role in copper radiopharmaceuticals, Curr Pharm Des, 13, 3, 10.2174/138161207779313768

Xie, 2009, Role of copper in angiogenesis and its medicinal implications, Curr Med Chem, 16, 1304, 10.2174/092986709787846622

Tabassum, 2010, Synthesis of carbo hydrate-conjugate heterobimetallic CuII-Sn2IV and ZnII-Sn2IV complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity, Eur J Med Chem, 45, 4797, 10.1016/j.ejmech.2010.07.046

Liu, 2011, Nitroimidazoles as anti-tumor agents, Anticancer Agents Med Chem, 11, 687, 10.2174/187152011796817664

Zhang, 2011, 2-chloro-N-[(4-chlorophenyl)(phenyl)-methyl]-N-[2-(4-nitro-1H-imidazol-1-yl)-ethyl]ethanamine, Acta Crystallogr Sect E, E67, o491, 10.1107/S160053681100256X

Yu, 2008, Synthesis of porphyrin-nitroimidazole derivatives and their radiosensitization, Chin J Med Chem, 18, 414

Valderrama-Negrón, 2011, Synthesis, spectroscopic characterization and radiosensitizing properties of acetato-bridged copper(II) complexes with 5-nitroimidazole drugs, Inorg Chim Acta, 367, 85, 10.1016/j.ica.2010.12.006

Souza, 2009, Synthesis, characterization and biological activities of mononuclear Co(III) complexes as potential bioreductively activated prodrugs, J Inorg Biochem, 103, 1355, 10.1016/j.jinorgbio.2009.07.008

Chen, 2009, Design of anticancer prodrugs for reductive activation, Med Res Rev, 29, 29, 10.1002/med.20137

Naura, 2009, Studies on mode of action of hexaammine Co(III) chloride against diethylnitrosamine-induced hepatocarcino-genesis in mice, J Biochem Mol Toxicol, 23, 193, 10.1002/jbt.20280

Nagababu, 2009, DNA-binding and cytotoxicity of the cobalt(III) ethylenediamine pyrazole complex [Co(en)2(pyz)2]3+, J Iran Chem Soc, 6, 145, 10.1007/BF03246513

Fernández, 2012, Influence of ligand denticity on the properties of novel 99mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue, Bioorg Med Chem, 20, 4040, 10.1016/j.bmc.2012.05.010

Rowinska-Zyrek, 2013, His-rich sequences is plagiarism from nature a good idea?, New J Chem, 37, 58, 10.1039/C2NJ40558J

Jin, 2009, Muscarine, imidazole, oxazole and thiazole alkaloids, Nat Prod Rep, 26, 382, 10.1039/b718045b

Sato, 2011, A cytotoxic imidazole alkaloid from the marine sponge jaspis duoaster, Chem Lett, 40, 186, 10.1246/cl.2011.186

Feng, 2010, Pseudoceratinazole A: A novel bromotyrosine alkaloid from the Australian sponge Pseudoceratina sp, Tetrahedron Lett, 51, 4847, 10.1016/j.tetlet.2010.07.052

Rudolph, 2013, Pteridine-, thymidine-, choline- and imidazole-derived alkaloids from the Australian ascidian, Leptoclinides durus, Org Biomol Chem, 11, 261, 10.1039/C2OB26879E

Morinaka, 2010, Amaranzoles B-F, imidazole-2-carboxy steroids from the marine sponge Phorbas amaranthus. C24-N- and C24-O-analogues from a divergent oxidative biosynthesis, J Org Chem, 75, 2453, 10.1021/jo1000324

Du, 2010, Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities, J Antibiot, 63, 165, 10.1038/ja.2010.11

Witchard, 2010, Synthesis of 5-amino-3-methylimidazolidine-2,4-dione and 1,3,5-triazine derivatives as analogues of the alkaloids naamidine A and G, Synthesis, 2010, 4312, 10.1055/s-0030-1258963

Flint, 2012, DNA damage as a result of psychological stress: Implications for breast cancer, Breast Cancer Res, 14, 320, 10.1186/bcr3189

Li, 2009, Ethidium bromide fluorescence probe on the interaction between dinuclear macrocyclic polyamine Zn(II) complex and DNA, Chin J Appl Chem, 26, 1461

Tansil, 2011, Electropolymerization of intercalator-grafted conducting polymer for direct and amplified DNA detection, Chem Commun, 47, 1533, 10.1039/C0CC03698F

Chen, 2011, Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand, Bioorg Med Chem Lett, 21, 1004, 10.1016/j.bmcl.2010.12.019

Özkay, 2010, Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H- imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity, Eur J Med Chem, 45, 3320, 10.1016/j.ejmech.2010.04.015

Satam, 2012, Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5′-ACGCGT-3′, Bioorg Med Chem, 20, 693, 10.1016/j.bmc.2011.12.010

Zhang, 2008, Advances in the research of the alkylating anticancer agents, Chin Pharma J, 44, 1281

Zbancioc, 2010, Design, synthesis and in vitro anticancer activity of a new class of bifunctional DNA intercalators, Lett Drug Des Discov, 7, 644, 10.2174/157018010792929504

Song, 2012, Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans, RSC Advances, 2, 4612, 10.1039/c2ra20376f

Zhang, 2011, Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents, Bioorg Med Chem Lett, 21, 1010, 10.1016/j.bmcl.2010.12.020

Huang, 2010, Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)-methyl]-3-(trifluoro methyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant, J Med Chem, 53, 4701, 10.1021/jm100395q

Potter, 2010, Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution, Bioorg Med Chem Lett, 20, 6483, 10.1016/j.bmcl.2010.09.063

Cummings, 2009, Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based a-helix mimetic, Org Lett, 11, 25, 10.1021/ol8022962

Patel, 2010, QSAR study on hetaryl imidazoles: A novel dual inhibitor of VEGF receptors I and II, Med Chem, 6, 24, 10.2174/157340610791208736

Dimova, 2012, Assessing the target differentiation potential of imidazole-based protein kinase inhibitors, J Med Chem, 55, 11067, 10.1021/jm3014508

Kontogiorgis, 2010, Thromboxane synthase inhibitors and thromboxane A2 receptor antagonists: A quantitative structure activity relationships (QSARs) analysis, Curr Med Chem, 17, 3162, 10.2174/092986710792231978

Sorrenti, 2012, Evaluation of imidazole-based compounds as heme oxygenase-1 inhibitors, Chem Biol Drug Des, 80, 876, 10.1111/cbdd.12015

Vlahakis, 2012, Heme oxygenase inhibition by a-(1H-imidazol-1-yl)-w-phenylalkanes: Effect of introduction of heteroatoms in the alkyl linker, ChemMedChem, 7, 897, 10.1002/cmdc.201100602

Roman, 2010, Heme oxygenase inhibition by 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and their derivatives, ChemMedChem, 5, 1541, 10.1002/cmdc.201000120

Lanier, 2010, Design and synthesis of selective inhibitors of placental alkaline phosphatase, Bioorg Med Chem, 18, 573, 10.1016/j.bmc.2009.12.012

Stoops, 2011, Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, ACS Chem Biol, 6, 452, 10.1021/cb100305h

Alker, 2010, Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists, Bioorg Med Chem Lett, 20, 4521, 10.1016/j.bmcl.2010.06.026

Ai, 2012, Multi-targeted histone deacetylase inhibitors in cancer therapy, Curr Med Chem, 19, 475, 10.2174/092986712798918842

Jiang, 2012, Synthesis and biological evaluation of novel 2-(2-arylmethylene) hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents, Eur J Med Chem, 54, 534, 10.1016/j.ejmech.2012.05.039

Hauze, 2009, Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template, Bioorg Med Chem Lett, 19, 1986, 10.1016/j.bmcl.2009.02.043

Luo, 2011, Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors, Bioorg Med Chem, 19, 6069, 10.1016/j.bmc.2011.08.038

Wittine, 2012, Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations, Bioorg Med Chem, 20, 3675, 10.1016/j.bmc.2012.01.054

Santos, 2009, Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity, Bioorg Med Chem, 17, 6241, 10.1016/j.bmc.2009.07.050

Harusawa, 2010, Synthesis of two estradiol-imidazole c-ribonucleoside hybrid compounds exhibiting inhibitory effects agents type 1 17b-hydroxysteroid dehydrogenase, Heterocycles, 81, 2817, 10.3987/COM-10-12069

Yang, 2012, Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO, Bioorg Med Chem Lett, 22, 4907, 10.1016/j.bmcl.2012.04.104

Henise, 2011, Irreversible Nek2 kinase inhibitors with cellular activity, J Med Chem, 54, 4133, 10.1021/jm200222m

Jones, 2008, From natural products to small molecule ketone histone deacetylase inhibitors: Development of new class specific agents, Curr Pharm Des, 14, 545, 10.2174/138161208783885317

Bressi, 2010, Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity, Bioorg Med Chem Lett, 20, 3138, 10.1016/j.bmcl.2010.03.092

Attenni, 2009, Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model, Bioorg Med Chem Lett, 19, 3081, 10.1016/j.bmcl.2009.04.011

Dave, 2011, An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II, Bioorg Med Chem Lett, 21, 2764, 10.1016/j.bmcl.2010.10.045

Malhotra, 2010, A profile of the in vitro anti-tumor activity of imidazolium-based ionic liquids, Bioorg Med Chem Lett, 20, 581, 10.1016/j.bmcl.2009.11.085

Yang, 2009, Synthesis and cytotoxic activities of novel phenacylimidazolium bromides, Bioorg Med Chem Lett, 19, 1892, 10.1016/j.bmcl.2009.02.065

Yang, 2012, Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole, Bioorg Med Chem Lett, 22, 2726, 10.1016/j.bmcl.2012.02.094

Lesuisse, 2011, Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors, Bioorg Med Chem Lett, 21, 2224, 10.1016/j.bmcl.2011.03.003

Khanfar, 2010, Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis, Eur J Med Chem, 45, 5397, 10.1016/j.ejmech.2010.08.066

Kathiravan, 2012, The biology and chemistry of antifungal agents: A review, Bioorg Med Chem, 20, 5678, 10.1016/j.bmc.2012.04.045

Zhai, 2011, Recent progress on antifungal drug development, Curr Pharm Biotechnol, 12, 1255, 10.2174/138920111796117292

Ashley, 2010, Antifungal Therapy, 199

Pierard, 2006, New insights in the effects of topical ketoconazole, Curr Top Pharmacol, 10, 59

Pierard, 2012, Miconazole, a pharmacological barrier to skin fungal infections, Expert Opin pharmacother, 13, 1187, 10.1517/14656566.2012.687047

Veraldi, 2008, Topical fenticonazole in dermatology and gynaecology: Current role in therapy, Drugs, 68, 2183, 10.2165/00003495-200868150-00007

Koga, 2009, In vitro antifungal activities of luliconazole, a new topical imidazole, Med Mycol, 47, 640, 10.1080/13693780802541518

Zhou, 2009, Preparation of Fluotrimazole ether derivatives as antimicrobial agents, CN Patent, CN101391986

Lamberth, 2013, Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 3: Imidazoles, Bioorg Med Chem, 21, 127, 10.1016/j.bmc.2012.10.052

Mangas-Sánchez, 2011, Asymmetric chemoenzymatic synthesis of miconazole and econazole enantiomers. The importance of chirality in their biological evaluation, J Org Chem, 76, 2115, 10.1021/jo102459w

Aboul-Enein, 2011, Synthesis and anti-Candida potential of certain novel 1-[(3-substituted-3-phenyl)propyl]-1H-imidazoles, Arch Pharm, 344, 794, 10.1002/ardp.201000224

De Vita, 2012, Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives, Eur J Med Chem, 49, 334, 10.1016/j.ejmech.2012.01.034

Bhandari, 2009, Tetrahydronaphthyl azole oxime ethers: The conformationally rigid analogues of oxiconazole as antibacterials, Eur J Med Chem, 44, 437, 10.1016/j.ejmech.2008.01.006

Emami, 2009, 3-Imidazolyl-substituted flavans as potential antifungal agents: Synthesis, stereochemical properties, and antifungal activity, Arch Pharm, 342, 541, 10.1002/ardp.200900024

Emami, 2009, Design of conformationally constrained azole antifungals: Efficient synthesis and antifungal activity of trans-3-imidazolylflavanones, Chem Biol Drug Des, 73, 388, 10.1111/j.1747-0285.2009.00797.x

El Hage, 2011, Synthesis, antibacterial and antifungal activities of bifonazole derivatives, Arch Pharm, 344, 402, 10.1002/ardp.201000304

Petrov, 2009, New imidazole derivatives of 2(3H)-benzazolones as potential antifungal agents, J Heterocycl Chem, 46, 44, 10.1002/jhet.11

Rezaei, 2011, Design, synthesis and antifungal activity of some new imidazole and triazole derivatives, Arch Pharm, 344, 658, 10.1002/ardp.201000357

Khabnadideh, 2009, Design and synthesis of 2-methyl and 2-methyl-4-nitro imidazole derivatives as antifungal agents, Iranian J Pharm Sci, 5, 31

Fringuelli, 2009, Bulky 1,4-benzoxazine derivatives with antifungal activity, Bioorg Med Chem, 17, 3838, 10.1016/j.bmc.2009.04.051

Marona, 2009, Antifungal and antibacterial activity of the newly synthesized 2-xanthone derivatives, Arch Pharm, 342, 9, 10.1002/ardp.200800089

Saiz-Urra, 2009, Synthesis and quantitative structure-antifungal activity relationships of clovane derivatives against Botrytis cinerea, J Agric Food Chem, 57, 2420, 10.1021/jf8033978

Salimon, 2010, New Schiff bases derivatives containing anthracene and 1,3,4-thidiazole moieties: Synthesis and fungicidal activity, Int J PharmTech Res, 2, 205

Sharma, 2011, Coordination compounds of hydroxamatooxovanadium(IV) complexes with nitrogenous bases and their antimicrobial activities, Bull Chem Soc Jpn, 84, 855, 10.1246/bcsj.20100205

Rodríguez-Argüelles, 2010, Evaluation of the antimicrobial activity of some chloro complexes of imidazole-2-carbaldehyde semicarbazone: X-ray crystal structure of cis-NiCl2 (H2L)(H2O), Polyhedron, 29, 864, 10.1016/j.poly.2009.10.011

Lakshmanan, 2010, Biologically active azoles: synthesis, characterization and antimicrobial activity of some 1-substituted imidazoles, Pharmacia Lettre, 2, 82

Emami, 2011, Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]- 2-(azol-1-yl)ethanone derivatives: Exploring the scaffold flexibility, Chem Biol Drug Des, 78, 979, 10.1111/j.1747-0285.2011.01243.x

Ramachandran, 2011, Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives, Eur J Med Chem, 46, 1926, 10.1016/j.ejmech.2011.02.036

Mokale, 2010, Synthesis and antifungal activity 2,6-bis (substituted phenyl)-1,4-dihydro-3,5-di(1H-imidazol-1-yl)-4-(substituted phenyl) pyridine derivatives, Pharma Chemica, 2, 133

Shi, 2011, Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents, Bioorg Med Chem Lett, 21, 956, 10.1016/j.bmcl.2010.12.059

Shi, 2011, Synthesis and antimicrobial evaluation of coumarin-based benzotriazoles and their synergistic effects with chlromycin and fluconazole, Acta Pharm Sinica, 46, 798

Damu, 2012, Coumarin-based triazole compounds with preparation method and pharmaceutical use thereof, CN Patent, CN103422813

Damu, 2012, Coumarin-based triazole alcohols with preparation method and pharmaceutical use thereof, CN Patent, CN103422800

Zhou, 2012, Preparation of coumarin containing azole compounds as antifungal, anti-AIDS, and antiinfectious agents, CN Patent, CN102040592

Parameshwar, 2011, Synthesis and antifungal screening of some novel coumarin linked imidazole derivatives, Res J Pharm Biol Chem Sci, 2, 514

Thareja, 2010, Novel chromeneimidazole derivatives as antifungal compounds: Synthesis and in vitro evaluation, Acta Pol Pharm, 67, 423

Jin, 2010, New progress in study on biological activities of chalcones, Chin J Biochem Pharm, 31, 358

Liu, 2013, Syntheses and biological activity of chalcones-imidazole derivatives, Res Chem Intermed, 39, 1037, 10.1007/s11164-012-0665-z

Zhou, 2011, 2′-Aminochalcone, pyrazoline, cyclopropylazole derivatives and their preparation, pharmaceutical compositions and use in the treatment of diseases, CN Patent, CN102060792

Hussain, 2009, Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones, Eur J Med Chem, 44, 4654, 10.1016/j.ejmech.2009.06.038

Singh, 2011, Synthesis of novel pyrazole derivative containing aryl phenyl ether as potential antifungal agent, J Korean Chem Soc, 55, 153, 10.5012/jkcs.2011.55.2.153

Meng, 2009, Advances in the research of benzimidazole drugs, Chin J New Drugs, 18, 1505

Zhou, 2009, Dibenzimidazole and onium compound thereof, preparation method and medical use thereof, CN Patent, CN101397276

Zhang, 2013, Design, synthesis and antimicrobial evaluation of novel benzimidazole type of fluconazole analogues and their synergistic effects with chloromycin, norfloxacin and fluconazole, Eur J Med Chem, 64, 329, 10.1016/j.ejmech.2013.03.049

Zhang, 2012, Synthesis and antimicrobial activities of novel benzimidazole derivatives and their binding behavior with bovine serum albumin, Eur J Med Chem, 55, 164, 10.1016/j.ejmech.2012.07.015

Zhou, 2012, Preparation of benzimidazolamine derivatives as antibacterial and/or antifungal agents, CN Patent, CN102659687

Özkay, 2011, Antimicrobial activity of a new combination system of benzimidazole and various azoles, Arch Pharm, 344, 264, 10.1002/ardp.201000172

Yang, 2012, Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity, Bioorg Med Chem Lett, 22, 1455, 10.1016/j.bmcl.2011.11.115

Trivedi, 2011, Synthesis of some 2-methyl-5-nitroimidazole derivatives as potential antimicrobial agents, J Chem Pharm Res, 3, 313

Nowakowska, 2008, Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones, Eur J Med Chem, 43, 707, 10.1016/j.ejmech.2007.05.006

Zhou, 2011, Benzyl chloride tertiary amine double azole antimicrobial compounds, preparation and medical use thereof, CN Patent, CN101323594

Zhou, 2012, Method for preparation of berberine-azole derivative and application as antibacterial and antifungal agents, CN Patent, CN102516242

Zhou, 2011, Medical application of halobenzyl tertiary amine type dibromo antimicrobial compound, CN Patent, CN102140066

Zhou, 2011, Bioactive diaryl tert-amino-azole derivatives and their preparation, pharmaceutical compositions and use in the treatment of diseases, CN Patent, CN102060793

Wan, 2012, Recent advances in antifungal fluconazole, Chin J Antibiot, 37, 8

Fang, 2010, Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents, Eur J Med Chem, 45, 4388, 10.1016/j.ejmech.2010.06.012

Zhang, 2013, Berberine azoles as antimicrobial agents: Synthesis, biological evaluation and their interactions with human serum albumin, MedChemComm, 4, 839, 10.1039/c3md00032j

Zhou, 2011, Sugar-diaryl triazole compound with antimicrobial activity and synthesis and medical application thereof, CN Patent, CN102086221

Taile, 2010, Synthesis and biological evaluation of novel 2-(4-O-b-D-glucosidoxyphenyl)-4,5-disubstituted imidazoles, J Heterocycl Chem, 47, 903, 10.1002/jhet.433

Konda, 2011, Polyethylene glycol (PEG-400): An efficient and recyclable reaction medium for the synthesis of novel 1,5-benzodiazepines and their antimicrobial activity, Chin Chem Lett, 22, 65, 10.1016/j.cclet.2010.09.012

Masman, 2009, Penetratin and derivatives acting as antifungal agents, Eur J Med Chem, 44, 212, 10.1016/j.ejmech.2008.02.019

Sharma, 2010, New antimicrobial hexapeptides: Synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies, ChemMedChem, 5, 86, 10.1002/cmdc.200900330

Nowak-Jary, 2009, Antifungal activity of thionated analogues of Nva-FMDP and Lys-Nva-FMDP, Polish J Microbiol, 58, 295

Wang, 2009, Increased potency of a novel D-b-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens, Yeast Res, 9, 967, 10.1111/j.1567-1364.2009.00531.x

Karlsson, 2009, Effect of sequence and structural properties on 14-helical b-peptide activity against Candida albicans planktonic cells and biofilms, ACS Chem Biol, 4, 567, 10.1021/cb900093r

Arnusch, 2012, Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents, J Med Chem, 55, 1296, 10.1021/jm2014474

Garibotto, 2010, New small-size peptides possessing antifungal activity, Bioorg Med Chem, 18, 158, 10.1016/j.bmc.2009.11.009

Grimaldi, 2010, Synthesis of new antifungal peptides selective against Cryptococcus neoformans, Bioorg Med Chem, 18, 7985, 10.1016/j.bmc.2010.09.033

Li, 2009, Catalytic hydrolysis and supramolecular recognition by benzimidazoly macrocyclic polyamine Zn(II) complex, Chem Res Appl, 21, 1375

Padmavathi, 2010, Synthesis and bioassay of pyrrolyl oxazolines and thiazolines, Eur J Med Chem, 45, 3178, 10.1016/j.ejmech.2010.04.010

Rajakumar, 2011, Synthesis and antimicrobial activity of some novel dicationic sulphonophanes, Eur J Med Chem, 46, 3093, 10.1016/j.ejmech.2011.03.063

Cai, 2009, Recent advance in the research of piperazine-containing compounds as antimicrobial agents, Chin J Antibiot, 34, 454

Zhou, 2009, Triazoles compounds with antimicrobial activity and preparation method and pharmaceutical use thereof, CN Patent, CN101445488

Wang, 2010, Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities, Eur J Med Chem, 45, 4631, 10.1016/j.ejmech.2010.07.031

Peng, 2013, Recent developments in azole compounds as antibacterial and antifungal agents, Curr Top Med Chem, 13, 10.2174/15680266113139990125

Zhang, 2013, Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to human serum albumin, Bioorg Med Chem Lett, 23, 1008, 10.1016/j.bmcl.2012.12.036

Khabnadideh, 2007, Synthesis of metronidazole derivatives as antigiardiasis agents, DARU J Pharm Sci, 15, 17

Wang, 2010, Advance in research of antimicrobial drugs with sulfamide group, Chin J New Drug, 19, 30

Zhou, 2010, Bistriazolone, bistriadimenol compounds with antimicrobial activity, and salts, synthesis method and uses thereof, CN Patent, CN101817792

Damu, 2013, A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents, Sci China Chem, 10.1007/s11426-013-4873-1

Khabnadideh, 2012, Antibacterial activity of some new azole compounds, Anti Infect Agents, 10, 26, 10.2174/2211362611201010026

Munoz-Bonilla, 2012, Polymeric materials with antimicrobial activity, Prog Polym Sci, 37, 281, 10.1016/j.progpolymsci.2011.08.005

Huang, 2011, Synthesis, characterization and bioactivity research of a derivative of secnidazole: 1-(2-chloropropyl)-2-methyl-5-nitro-1H-imidazole, J Chem Crystallogr, 41, 1360, 10.1007/s10870-011-0104-9

Sharma, 2009, Convenient one-pot synthesis of novel 2-substituted benzimidazoles, tetrahydrobenzimidazoles and imidazoles and evaluation of their in vitro antibacterial and antifungal activities, Eur J Med Chem, 44, 1751, 10.1016/j.ejmech.2008.03.026

Aonofriesei, 2013, Inhibitory potential of a novel imidazole derivative as evaluated by time-kill and dehydrogenase activity, Curr Microbiol, 66, 162, 10.1007/s00284-012-0252-y

Kanbak, 2009, Synthesis of new 4(1H)-pyridinone derivatives and their antibacterial activity, Rev Chim (Bucuresti), 60, 888

Zhang, 2010, New progress of researches in carbazole compounds, Chin J Org Chem, 30, 783

Zhou, 2011, Process for preparation of carbazole containing chalcone derivatives, CN Patent, CN101993432

Thevissen, 2009, Antifungal carbazoles, Curr Med Chem, 16, 2205, 10.2174/092986709788612701

Zhang, 2010, Synthesis, antibacterial and antifungal activities of some carbazole derivatives, Bioorg Med Chem Lett, 20, 1881, 10.1016/j.bmcl.2010.01.159

Zhang, 2013, Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin, Bioorg Med Chem, 10.1016/j.bmc.2013.05.007

Su, 2010, A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity, Org Biomol Chem, 8, 2814, 10.1039/c001479f

Soliman, 2012, Synthesis and biological activity of dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazins, Eur J Med Chem, 47, 138, 10.1016/j.ejmech.2011.10.034

Krátky, 2011, Salicylanilide ester prodrugs as potential antimicrobial agents-A review, Curr Pharm Des, 17, 3494, 10.2174/138161211798194521

Singh, 2010, Synthesis and antimicrobial activity of some novel 2-amino thiazole derivatives, J Chem Pharm Res, 2, 691

Letafat, 2011, Synthesis and in vitro antibacterial activity of new 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles, Eur J Chem, 8, 1120

Suresh, 2010, Synthesis, antibacterial, antifungal and antioxidant activity studies on 2-benzylthio- and 2-benzylsulfonyl-1H-imidazoles, Pharmacia Lettre, 2, 393

Narasimhan, 2011, Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones, J Enzyme Inhib Med Chem, 26, 720, 10.3109/14756366.2010.548331

Sharma, 2009, Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives, Eur J Med Chem, 44, 2347, 10.1016/j.ejmech.2008.08.010

Aridoss, 2009, Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6- diarylpiperidin-4-ones, Eur J Med Chem, 44, 4199, 10.1016/j.ejmech.2009.05.015

Aridoss, 2009, Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4- ones: Antimicrobial, analgesic and antipyretic studies, Eur J Med Chem, 44, 577, 10.1016/j.ejmech.2008.03.031

Aridoss, 2010, Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol, Bioorg Med Chem Lett, 20, 2242, 10.1016/j.bmcl.2010.02.015

Turtaut, 2011, Synthesis and biological evaluation of a new class of anti- brucella compounds targeting histidinol dehydrogenase: a-O-arylketones and a-S-arylketones derived from histidine, MedChemComm, 2, 995, 10.1039/c1md00146a

Siwek, 2011, Biological and docking studies of topoisomerase IV inhibition by thiosemicarbazides, J Mol Model, 17, 2297, 10.1007/s00894-010-0889-z

Yap, 2009, Porphyrin-linked nitroimidazole antibiotics targeting Porphyromonas gingivalis, Org Biomol Chem, 7, 2855, 10.1039/b904340c

East, 2009, DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity, Bioorg Med Chem Lett, 19, 894, 10.1016/j.bmcl.2008.11.102

Abdel-Wahab, 2011, Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles, Eur J Med Chem, 46, 1505, 10.1016/j.ejmech.2011.01.062

Gouda, 2010, Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrobenzothiophene moiety, Eur J Med Chem, 45, 1338, 10.1016/j.ejmech.2009.12.020

Omar, 2010, Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs, Bioorg Med Chem, 18, 426, 10.1016/j.bmc.2009.10.041

Nanda, 2010, Synthesis of some benzothiazolyl and imidazole derivatives and evaluation of antibacterial activities, J Chem Pharm Res, 2, 785

Gan, 2009, Advances in the research of piperazine compounds as receptor ligands, Chin Pharma J, 44, 1361

Basarab, 2012, Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailability, Bioorg Med Chem Lett, 22, 5600, 10.1016/j.bmcl.2012.07.004

Yu, 2009, Study on the synthesis and antimicrobial activity of novel cationic porphyrins, Chin Chem Lett, 20, 411, 10.1016/j.cclet.2008.11.030

Gan, 2009, Advances in the research of piperazine compounds as enzyme inhibitors, Chin J Biochem Pharm, 30, 127

Wang, 2012, Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents, Bioorg Med Chem Lett, 22, 5363, 10.1016/j.bmcl.2012.07.064

Zhou, 2012, Carbostyril compounds and the preparation method and application thereof, CN Patent, CN102627630

Pattan, 2009, Synthesis and evaluation of some new 6-fluro-quinolin-4(1H)-one derivatives for their anti-microbial activities, J Pharm Sci Res, 1, 55

Mahale, 2011, Synthesis and antibacterial activities of new dibenzothiazepine derivatives, Indian J Chem, 50B, 1196

Khalaj, 2011, Discovery of a novel nitroimidazolyleoxazolidinone hybrid with potent anti-Gram-positive activity: Synthesis and antibacterial evaluation, Eur J Med Chem, 46, 65, 10.1016/j.ejmech.2010.10.015

Sirisha, 2011, Synthesis, antibacterial and antimycobacterial activities of some new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines, Eur J Med Chem, 46, 1564, 10.1016/j.ejmech.2011.02.003

Prashantha-Kumar, 2010, Synthesis of novel hantzsch dihydropyridines and biginelli dihydropyrimidines of biological interest: A 3D-QSAR study on their cytotoxicity, Med Chem Res, 19, 344, 10.1007/s00044-009-9195-7

Akbarzadeh, 2010, Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl -1,4-dihydropyridine derivatives, DARU J Pharm Sci, 18, 118

Jain, 2010, Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives, Asian Pacific J Tropical Med, 3, 471, 10.1016/S1995-7645(10)60113-7

Satyanarayana, 2011, An efficient and novel one-pot synthesis of 2,4,5-triaryl-1-imidazoles catalyzed by UO2 (NO3)2·6H2O under heterogeneous conditions, Chem Pap, 65, 519, 10.2478/s11696-011-0028-z

Wang, 2012, Synthesis and biological activities of thio-triazole derivatives as new potential antibacterial and antifungal agents, Sci China Chem, 55, 2134, 10.1007/s11426-012-4602-1

Amir, 2011, Design and synthesis of some azole derivatives containing 2,4,5-triphenyl imidazole moiety as anti-inflammatory and antimicrobial agents, Indian J Chem, 50, 207

Satyanarayana, 2011, Synthesis characterization of some new five membered heterocycles based on imidazole moiety and their applications on therapeutics, Lett Drug Des Discov, 8, 276, 10.2174/157018011794578196

Satyanarayana, 2010, Ultrasound-assisted synthesis of some new Schiff base derivatives incorporating imidazole moiety, their characterization and biological evaluation, J Pharm Res, 3, 2327

Demain, 2009, Antibiotics: Natural products essential to human health, Med Res Rev, 29, 821, 10.1002/med.20154

Kumar, 2012, Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens, Bioorg Med Chem Lett, 22, 476, 10.1016/j.bmcl.2011.10.101

La Marche, 2011, 4-Aminothiazolyl analogs of GE2270 A: Design, synthesis and evaluation of imidazole analogs, Bioorg Med Chem Lett, 21, 3210, 10.1016/j.bmcl.2011.04.048

Van der Knaap, 2011, Evaluation of readily accessible azoles as mimics of the aromatic ring of D-phenylalanine in the turn region of gramicidin S, ChemMedChem, 6, 840, 10.1002/cmdc.201000539

Zhou, 2009, Triazole onium compound with antimicrobial activity, preparation method and medical use, CN Patent, CN101391985

Luo, 2009, Synthesis, antibacterial and antifungal activities of novel 1,2,4-triazolium derivatives, Arch Pharm, 342, 386, 10.1002/ardp.200800221

Coleman, 2012, Antimicrobial toxicity studies of ionic liquids leading to a ‘hit’ MRSA selective antibacterial imidazolium salt, Green Chem, 14, 1350, 10.1039/c2gc16090k

Noujeim, 2010, Imidazolium cations in organic chemistry: From chemzymes to supramolecular building blocs, Curr Org Chem, 14, 1500, 10.2174/138527210791616830

Tiekink, 2012, Therapeutic potential of selenium and tellurium compounds: Opportunities yet unrealized, Dalton Trans, 41, 6390, 10.1039/c2dt12225a

Alberto, 2011, Imidazolium ionic liquids containing selenium: Synthesis and antimicrobial activity, Org Biomol Chem, 9, 1001, 10.1039/C0OB01010C

Garg, 2010, Anion effects on anti-microbial activity of poly[1-vinyl-3-(2-sulfoethyl imidazolium betaine)], J Colloid Interface Sci, 344, 90, 10.1016/j.jcis.2009.12.016

Colonna, 2012, Synthesis and characterization of imidazolium telechelic poly(butylene terephthalate) for antimicrobial applications, React Funct Polym, 72, 133, 10.1016/j.reactfunctpolym.2011.12.003

Baker, 2009, Mercury complexes of N-heterocyclic carbenes derived from imidazolium-linked cyclophanes: Synthesis, structure, and reactivity, Organometallics, 28, 3793, 10.1021/om8011745

Rajakumar, 2009, Investigation of the role of 1,3,4-oxadiazole on the spectroscopic, optical, and electrochemical properties of benzimidazolophanes, Tetrahedron Lett, 50, 223, 10.1016/j.tetlet.2008.10.142

Rajakumar, 2009, Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents, Eur J Med Chem, 44, 3040, 10.1016/j.ejmech.2008.07.031

Rajakumar, 2009, Synthesis and antibacterial activity of some novel imidazole-based dicationic quinolinophanes, Bioorg Med Chem Lett, 19, 3466, 10.1016/j.bmcl.2009.05.019

Savjani, 2011, Pharmaceutical importance and synthetic strategies for imidazolidine-2-thione and imidazole-2-thione derivatives, Pakistan J Biol Sci, 14, 1076, 10.3923/pjbs.2011.1076.1089

Fujisaki, 2010, Antibacterial activity of 5-dialkylamino methylhydantoins and related compounds, Chem Pharm Bull, 58, 1123, 10.1248/cpb.58.1123

Subramaniam, 2010, Synthesis and in vitro study of biological activity of 2,3-substituted quinazolin-4(3H)-ones, J Chem Pharm Res, 2, 462

Al-Tamamy, 2010, Synthesis and antibacterial activity of some new imidazole, imidazo[2,1-c]triazole and imidazo[1,2-e]tetrazole derivatives, Orient J Chem, 26, 421

Patel, 2010, Synthesis and antibacterial and antifungal studies of novel nitrogen containing heterocycles from 5-ethylpyridin-2-ethanol, Indian J Pharm Sci, 72, 613, 10.4103/0250-474X.78531

Atia, 2009, Synthesis and antibacterial activities of new metronidazole and imidazole derivatives, Molecules, 14, 2431, 10.3390/molecules14072431

Cui, 2013, Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA, Bioorg Med Chem Lett, 23, 3267, 10.1016/j.bmcl.2013.03.118

Parab, 2010, Synthesis, characterization and biological evaluation of quinoline based imidazole derivatives, Asian J Chem, 22, 7641

Kathrotiya, 2012, An efficient synthesis of 3′-quinolinyl substituted imidazole-5-one derivatives catalyzed by zeolite and their antimicrobial activity, Chin Chem Lett, 23, 273, 10.1016/j.cclet.2011.11.022

Sathe, 2011, Synthesis of anti-bacterial activity of some synthesized 2[21-phenyl-41-benzidinyl-51-oxo-imidazoline1yl-amino]-6 fluoro-7-substituted (1,3) benzothiazoles, J Pharm Res, 4, 585

Bondock, 2011, Synthesis and antimicrobial activity of some new 4-hetarylpyrazole and furo[2,3-c]pyrazole derivatives, Eur J Med Chem, 46, 2555, 10.1016/j.ejmech.2011.03.045

Vijesh, 2011, Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives, Eur J Med Chem, 46, 3531, 10.1016/j.ejmech.2011.05.005

Neelakantan, 2010, Synthesis, characterization, thermal and redox behavior, and biological activity of Ni(II), Cu(II), and Zn(II) complexes containing pyridoxine and imidazole moieties, J Coord Chem, 63, 1969, 10.1080/00958972.2010.493583

Arish, 2010, Synthesis, characterization, antimicrobial, and nuclease activity studies of some metal Schiff-base complexes, J Coord Chem, 63, 1619, 10.1080/00958972.2010.483729

Neelakantan, 2011, Synthesis, spectral and thermal studies of some transition metal mixed ligand complexes: Modeling of equilibrium composition and biological activity, Spectrochim Acta Part A, 79, 1693, 10.1016/j.saa.2011.05.037

Joseyphus, 2009, Synthesis, characterization and antimicrobial activity of transition metal complexes with the Schiff base derived from imidazole-2-carboxaldehyde and glycylglycine, J Coord Chem, 62, 319, 10.1080/00958970802236048

Barone, 2009, Spectroscopic study of the interaction of Ni(II)-5-triethyl ammonium methyl salicylidene ortho-phenylendiiminate with native DNA, J Inorg Biochem, 103, 731, 10.1016/j.jinorgbio.2009.01.006

Wojciechowska, 2011, Synthesis, crystal structure, spectroscopic, magnetic, theoretical, and microbiological studies of a Nickel(II) complex of L-tyrosine and imidazole, [Ni(Im)2L-tyr)2]·4H2O, Inorg Chem, 50, 11532, 10.1021/ic201471f

Liu, 2011, Group 11 metal compounds with tripodal bis(imidazole) thioether ligands. Applications as catalysts in the oxidation of alkenes and as antimicrobial agents, Molecules, 16, 6701, 10.3390/molecules16086701

Stover, 2000, A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis, Nature, 405, 962, 10.1038/35016103

Lima, 2011, Synthesis and antimycobacterial evaluation of N-(E)-heteroaromatic-pyrazine-2-carbohydrazide derivatives, Med Chem, 7, 245, 10.2174/157340611795564303

Thomas, 2011, Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents, Eur J Med Chem, 46, 5283, 10.1016/j.ejmech.2011.07.033

Upadhayaya, 2009, Design synthesis, biological evaluation and molecular modeling studies of novel quinoline derivatives against Mycobacterium tuberculosis, Bioorg Med Chem, 17, 2830, 10.1016/j.bmc.2009.02.026

Upadhayaya, 2010, Conformationally-constrained indeno[2,1-c]quinolines-a new class of anti-mycobacterial agents, Org Biomol Chem, 8, 2180, 10.1039/b924102g

Miranda, 2010, Synthesis of imidazole derivatives with antimycobacterial activity, Arch Pharm, 343, 40, 10.1002/ardp.200900149

Wei, 2011, Recent advances of 1,2,3-triazole compounds in medicinal chemistry, Chin Pharm J, 46, 481

Wei, 2011, Synthesis of novel D-glucose-derived benzyl and alkyl 1,2,3-triazoles as potential antifungal and antibacterial agents, Bull Korean Chem Soc, 32, 229, 10.5012/bkcs.2011.32.1.229

Tron, 2008, Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes, Med Res Rev, 28, 278, 10.1002/med.20107

Castagnolo, 2009, Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis, Bioorg Med Chem Lett, 19, 2203, 10.1016/j.bmcl.2009.02.101

Lee, 2011, Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole, Bioorg Med Chem Lett, 21, 1515, 10.1016/j.bmcl.2010.12.128

Fassihi, 2009, Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides, Eur J Med Chem, 44, 3253, 10.1016/j.ejmech.2009.03.027

Pandey, 2009, Synthesis and antitubercular screening of imidazole derivatives, Eur J Med Chem, 44, 3350, 10.1016/j.ejmech.2009.02.013

Singh, 2009, Chemistry and biology of synthetic and naturally occurring antiamoebic agents, Chem Rev, 109, 1900, 10.1021/cr068217k

Sanchez-Moreno, 2012, In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis species, J Antimicrob Chemother, 67, 387, 10.1093/jac/dkr480

Hammond, 2011, Synthesis and biological evaluation of a novel anti-malarial lead, Med Chem Res, 20, 401, 10.1007/s00044-010-9325-2

Glans, 2012, Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: Synthesis, characterization and in vitro antimalarial activity, Dalton Trans, 41, 2764, 10.1039/c2dt12083f

Dutta, 2010, Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles, Acta Pharm, 60, 229, 10.2478/v10007-010-0011-1

Baliani, 2005, Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites, J Med Chem, 48, 5570, 10.1021/jm050177+

Baliani, 2009, Novel functionalized melamine-based nitroheterocycles: Synthesis and activity against Trypanosomatid parasites, Org Biomol Chem, 7, 1154, 10.1039/b813394h

Sánchez-Moreno, 2012, Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection, J Med Chem, 55, 9900, 10.1021/jm3011004

Hernández-Núňez, 2009, Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles, Eur J Med Chem, 44, 2975, 10.1016/j.ejmech.2009.01.005

Trunz, 2011, 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis, Eur J Med Chem, 46, 1524, 10.1016/j.ejmech.2011.01.071

Kumar, 2011, Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception, Bioorg Med Chem Lett, 21, 176, 10.1016/j.bmcl.2010.11.042

Valdez, 2009, Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia, J Med Chem, 52, 4038, 10.1021/jm900356n

Dunn, 2010, A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro, Int J Antimicrob Agents, 36, 37, 10.1016/j.ijantimicag.2010.03.004

Gan, 2010, Synthesis of azole-containing piperazine derivatives and evaluation of their antibacterial, antifungal and cytotoxic activities, Bull Korean Chem Soc, 31, 3684, 10.5012/bkcs.2010.31.12.3684

Samant, 2011, Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis, Bioorg Med Chem Lett, 21, 1015, 10.1016/j.bmcl.2010.12.040

Ferreira, 2007, Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents, Eur J Med Chem, 42, 1388, 10.1016/j.ejmech.2007.02.020

Foroumadi, 2005, Synthesis and in vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives, Eur J Med Chem, 40, 1346, 10.1016/j.ejmech.2005.07.002

Marrapu, 2011, Synthesis and evaluation of new furanyl and thiophenyl azoles as antileishmanial agents, Eur J Med Chem, 46, 1694, 10.1016/j.ejmech.2011.02.021

Bhandari, 2010, Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agents, Bioorg Med Chem Lett, 20, 291, 10.1016/j.bmcl.2009.10.117

Marrapu, 2011, Design and synthesis of novel tetrahydronaphthyl azoles and related cyclohexyl azoles as antileishmanial agents, Bioorg Med Chem Lett, 21, 1407, 10.1016/j.bmcl.2011.01.026

Srinivas, 2009, Aryloxy cyclohexyl imidazoles: A novel class of antileishmanial agents, Bioorg Med Chem Lett, 19, 324, 10.1016/j.bmcl.2008.11.094

Maldonado, 2010, In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi, J Med Chem, 53, 6964, 10.1021/jm100581z

Carvalho, 2010, ‘Click chemistry’ synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase, Bioorg Med Chem, 18, 2412, 10.1016/j.bmc.2010.02.053

Da Silva, 2010, The evaluation of quinonoid compounds against Trypanosoma cruzi: Synthesis of imidazolic anthraquinones, nor-lapachone derivatives and b-lapachone-based 1,2,3-triazoles, Bioorg Med Chem, 18, 3224, 10.1016/j.bmc.2010.03.029

Sánchez-Moreno, 2011, In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of chagas disease, J Med Chem, 54, 970, 10.1021/jm101198k

Deng, 2010, Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials, Bioorg Med Chem Lett, 20, 4027, 10.1016/j.bmcl.2010.05.095

Liesen, 2010, Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazoli dinones and 1,3,4-thiadiazoles, Eur J Med Chem, 45, 3685, 10.1016/j.ejmech.2010.05.017

Birnkammer, 2012, The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists, J Med Chem, 55, 1147, 10.1021/jm201128q

Wu, 2007, Avance in H3 histamine receptor ligands, Chin Pharm J, 42, 404

Zampeli, 2009, The role of histamine H4 receptor in immune and inflammatory disorders, Br J Pharmacol, 157, 24, 10.1111/j.1476-5381.2009.00151.x

Bhatt, 2010, Histamine H4 Receptor: A novel therapeutic target for immune and allergic responses, Mini Rev Med Chem, 10, 1293, 10.2174/138955710793564124

Geyer, 2011, Synthesis and histamine H3 and H4 receptor activity of conformationally restricted cyanoguanidines related to UR-PI376, Arch Pharm, 344, 775, 10.1002/ardp.201100144

Tiligada, 2009, Histamine H3 and H4 receptors as novel drug targets, Expert Opin Invest Drugs, 18, 1519, 10.1517/14728220903188438

Broderick, 2011, Histamine H3 receptor (H3R) antagonists and inverse agonists in the treatment of sleep disorders, Curr Pharm Des, 17, 1426, 10.2174/138161211796197133

Łażewska, 2009, Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates, Bioorg Med Chem Lett, 19, 6682, 10.1016/j.bmcl.2009.10.005

Wi'cek, 2011, N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands, Bioorg Med Chem, 19, 2850, 10.1016/j.bmc.2011.03.046

Ishikawa, 2010, Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: Development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice, J Med Chem, 53, 3840, 10.1021/jm901890s

Ishikawa, 2010, Investigation of the Histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain, J Med Chem, 53, 6445, 10.1021/jm100643t

Ishikawa, 2010, Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor, Bioorg Med Chem, 18, 5441, 10.1016/j.bmc.2010.04.052

Kottke, 2011, Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands, Eur J Pharmacol, 654, 200, 10.1016/j.ejphar.2010.12.033

Wijtmans, 2011, Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity, J Med Chem, 54, 1693, 10.1021/jm1013488

Igel, 2009, Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists, J Med Chem, 52, 6297, 10.1021/jm900526h

Lim, 2009, Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: Synthesis, pharmacological evaluation, and cross-target QSAR studies, Bioorg Med Chem, 17, 3987, 10.1016/j.bmc.2009.04.007

Galley, 2012, Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012, Bioorg Med Chem Lett, 22, 5244, 10.1016/j.bmcl.2012.06.060

Hack, 2011, Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors, Eur J Med Chem, 46, 1483, 10.1016/j.ejmech.2011.01.042

Galley, 2012, Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012, Bioorg Med Chem Lett, 22, 5244, 10.1016/j.bmcl.2012.06.060

Seo, 2011, Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT2A receptor and 5-HT transporter, J Med Chem, 54, 6305, 10.1021/jm200682b

Gonçalves, 2012, The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: Evidence for the involvement of adrenergic, dopaminergic and serotonergic systems, Eur J Pharmacol, 674, 307, 10.1016/j.ejphar.2011.11.009

Lakatos, 2012, Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease, Dalton Trans, 41, 1713, 10.1039/C1DT10989H

Tyagarajan, 2010, Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers, Bioorg Med Chem Lett, 20, 5536, 10.1016/j.bmcl.2010.07.064

Hanna-Elias, 2010, Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands, Curr Med Chem, 17, 2775, 10.2174/092986710791859351

Galambos, 2010, Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists, Bioorg Med Chem Lett, 20, 4371, 10.1016/j.bmcl.2010.06.075

Karakurt, 2012, Synthesis of some novel 1-(2-naphthyl)-2- (imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity, Eur J Med Chem, 57, 275, 10.1016/j.ejmech.2012.08.037

Karakurt, 2010, Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives, Bioorg Med Chem, 18, 2902, 10.1016/j.bmc.2010.03.010

Çaliş, 2011, Synthesis and anticonvulsant evaluation of some novel (thio)semicarbazone derivatives of arylalkylimidazole, Arzneim-Forsch, 61, 327, 10.1055/s-0031-1296206

Ahangar, 2011, 1-[(2-Arylthiazol-4-yl) methyl]azoles as a new class of anticonvulsants: Design, synthesis, in vivo screening, and in silico drug-like properties, Chem Biol Drug Des, 78, 844, 10.1111/j.1747-0285.2011.01211.x

Koller, 2011, Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity, Bioorg Med Chem Lett, 21, 3358, 10.1016/j.bmcl.2011.04.017

Husain, 2011, Synthesis, anticonvulsant and neurotoxixity screening of some novel 1,2,4-trisubstituted-1H-imidazole derivatives, Acta Pol Pharm, 68, 657

Chiriano, 2012, A small chemical library of 2-aminoim idazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation, Eur J Med Chem, 48, 206, 10.1016/j.ejmech.2011.12.016

Brodney, 2011, Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease, Bioorg Med Chem Lett, 21, 2631, 10.1016/j.bmcl.2010.12.117

Brodney, 2011, Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014, Bioorg Med Chem Lett, 21, 2637, 10.1016/j.bmcl.2010.12.118

Helal, 2009, Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease, Bioorg Med Chem Lett, 19, 5703, 10.1016/j.bmcl.2009.08.019

Areias, 2012, New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships, Eur J Med Chem, 54, 303, 10.1016/j.ejmech.2012.05.009

Karlsson, 2012, Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation, Eur J Pharm Sci, 45, 169, 10.1016/j.ejps.2011.11.004

Vacher, 2010, Rigid analogues of the a2-adrenergic blocker atipamezole: Small changes, big consequences, J Med Chem, 53, 6986, 10.1021/jm1006269

Wager, 2010, Moving beyond rules: The development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties, ACS Chem Neurosci, 1, 435, 10.1021/cn100008c

Asproni, 2011, Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors, Bioorg Med Chem, 19, 642, 10.1016/j.bmc.2010.10.038

Sugimoto, 2009, Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: Exploration and optimization of alternative pyrazole structure, Bioorg Med Chem Lett, 19, 4611, 10.1016/j.bmcl.2009.06.095

Lange, 2010, Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism, J Med Chem, 53, 1338, 10.1021/jm901614b

Yoon, 2009, N-methyl amine-substituted fluoxetine derivatives: New dopamine transporter inhibitors, Arch Pharm Res, 32, 1663, 10.1007/s12272-009-2201-2

Butini, 2009, Novel, potent, and selective quinoxaline-based 5-HT3 receptor ligands. 1. Further structure-activity relationships and pharmacological characterization, J Med Chem, 52, 6946, 10.1021/jm901126m

Salerno, 2012, Novel inhibitors of nitric oxide synthase with antioxidant properties, Eur J Med Chem, 49, 118, 10.1016/j.ejmech.2012.01.002

Yang, 2011, Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain, Bioorg Med Chem Lett, 21, 182, 10.1016/j.bmcl.2010.11.044

Lange, 2010, Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies, Bioorg Med Chem Lett, 20, 1084, 10.1016/j.bmcl.2009.12.032

Nshimyumukiza, 2010, Synthesis and biological evaluation of novel imidazole-containing macrocycles, Tetrahedron, 66, 4515, 10.1016/j.tet.2010.04.070

Baumann, 2011, An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals, Beilstein J Org Chem, 7, 442, 10.3762/bjoc.7.57

Prasad, 2012, An efficient and straight forward synthesis of (5S)-1-benzyl-5- (1H-imidazol-1-ylmethyl)-2-pyrrolidinone (MM1): A novel antihypertensive agent, Med Chem Res, 21, 321, 10.1007/s00044-010-9536-6

Agelis, 2012, The discovery of new potent non-peptide angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives, Eur J Med Chem, 55, 358, 10.1016/j.ejmech.2012.07.040

Agelis, 2010, An efficient synthesis of a rationally designed 1,5-disubstituted imidazole AT1 angiotensin II receptor antagonist: Reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies, J Comput Aided Mol Des, 24, 749, 10.1007/s10822-010-9371-3

Hadizadeh, 2010, Synthesis and effects of novel dihydropyridines as dual calcium channel blocker and angiotensin antagonist on isolated rat aorta, Iran J Basic Med Sci, 13, 195

García, 2012, New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers, Eur J Med Chem, 50, 90, 10.1016/j.ejmech.2012.01.043

Iman, 2011, Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker, Arch Pharm Res, 34, 1417, 10.1007/s12272-011-0902-9

Malhotra, 2011, Substituted imidazole derivatives as novel cardiovascular agents, Bioorg Med Chem Lett, 21, 936, 10.1016/j.bmcl.2010.12.062

Gautam, 2009, Recent developments in anti-inflammatory natural products, Med Res Rev, 29, 767, 10.1002/med.20156

Yu, 2012, Synthesis and biological evaluation of acridine derivatives as antimalarial agents, ChemMedChem, 7, 587, 10.1002/cmdc.201100554

Grimstrup, 2010, Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2, Bioorg Med Chem Lett, 20, 1181, 10.1016/j.bmcl.2009.12.015

Grimstrup, 2010, Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists, Bioorg Med Chem Lett, 20, 1638, 10.1016/j.bmcl.2010.01.092

Raghavendra, 2011, Microwave synthesis and anti-inflammatory evaluation of some new imidazolo quinoline analogs, Rasayan J Chem, 4, 91

Scior, 2011, Pharmacophore design of p38a MAP kinase inhibitors with either 2,4,5-trisubstituted or 1,2,4,5-tetrasubstituted imidazole scaffold, Curr Med Chem, 18, 1526, 10.2174/092986711795328409

Hernández, 2012, Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives, Bioorg Med Chem, 20, 2158, 10.1016/j.bmc.2012.01.034

Tripathy, 2010, Parallel synthesis of tetra substituted imidazoles by microwave irradiation and evaluation of their anti-inflammatory activity, Res J Pharm Biol Chem Sci, 1, 31

Gaonkar, 2009, Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives, Med Chem Res, 18, 221, 10.1007/s00044-008-9121-4

Chu, 2009, Design and synthesis of imidazopyrimidine derivatives as potent iNOs dimerization inhibitors, Open Med Chem J, 3, 8, 10.2174/1874104500903010008

Assadieskandar, 2012, Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors, Bioorg Med Chem, 20, 7160, 10.1016/j.bmc.2012.09.050

Che, 2010, 1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells, Bioorg Med Chem Lett, 20, 4035, 10.1016/j.bmcl.2010.05.092

Husain, 2009, Synthesis and biological screening of di- and tri-substituted imidazoles, Acta Pol Pharm, 66, 243

Saberi, 2010, Synthesis and effects of 4,5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazoles as selective cyclooxygenase inhibitors, Iran J Basic Med Sci, 13, 225

Wang, 2011, Synthesis and their evaluation for their antimicrobial activity of diphenyl piperazine-based sulfanilamides, Sci Sin Chim, 41, 451, 10.1360/032010-605

Zhou, 2011, [Chloro(sulfonylphenyl)vinyl]azole derivatives with antimicrobial activity and their preparation, pharmaceutical compositions and use in the treatment of infections, CN Patent, CN102079724

Ren, 2011, Synthesis and potent biological activity of 1-sulfonyl substituted imidazole and benzo[d]imidazole compounds, Adv Mater Res, 236-238, 2570, 10.4028/www.scientific.net/AMR.236-238.2570

Yasodha, 2009, Synthesis and biological evaluation of some 2,4,5-triphenyl imidazole derivatives, J Pharm Sci Res, 1, 127

Umarani, 2011, Exploring the effects of newer three component aminobenzylated reactions of triphenyl imidazole motif as potent antimicrobial and anti-inflammatory agents, Int J Pharm Pharm Sci, 3, 62

Huang, 2012, Insight into the structural determinants of imidazole scaffold-based derivatives as p38 MAP kinase inhibitors by computational explorations, Curr Med Chem, 19, 4024, 10.2174/092986712802002608

Lee, 2005, MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38 protein, Curr Med Chem, 12, 2979, 10.2174/092986705774462914

Selig, 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors, J Med Chem, 55, 8429, 10.1021/jm300852w

Abu Thaher, 2009, Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38a mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors, J Med Chem, 52, 2613, 10.1021/jm801467h

Bracht, 2010, Synthesis and biological testing of N-aminoimidazole-based p38a MAP kinase inhibitors, ChemMedChem, 5, 1134, 10.1002/cmdc.201000114

Ziegler, 2009, 2-Acylaminopyridin-4-yl imidazoles as p38 MAP kinase inhibitors: Design, synthesis, and biological and metabolic evaluations, ChemMedChem, 4, 1939, 10.1002/cmdc.200900242

Laufer, 2010, Tri- and tetra-substituted imidazoles as p38a mitogen-activated protein kinase inhibitors, Bioorg Med Chem Lett, 20, 6671, 10.1016/j.bmcl.2010.09.012

Koch, 2010, Unexpected reaction of 2-alkylsulfanylimidazoles to imidazol-2-ones: Pyridinylimidazol-2-ones as novel potent p38a mitogen-activated protein kinase inhibitors, J Med Chem, 53, 4798, 10.1021/jm100161q

Wu, 2010, Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1, Bioorg Med Chem Lett, 20, 6978, 10.1016/j.bmcl.2010.09.129

Forster, 2010, 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A2a and fatty acid amide hydrolase, Bioorg Med Chem, 18, 945, 10.1016/j.bmc.2009.11.028

Sun, 2011, Discovery of S-nitrosoglutathione reductase inhibitors: Potential agents for the treatment of asthma and other inflammatory diseases, ACS Med Chem Lett, 2, 402, 10.1021/ml200045s

Kagayama, 2009, Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1, Bioorg Med Chem, 17, 6959, 10.1016/j.bmc.2009.08.014

Moutevelis-Minakakis, 2011, Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity, Bioorg Med Chem, 19, 2888, 10.1016/j.bmc.2011.03.044

Cushing, 2011, A novel series of IKKb inhibitors part 1: Initial SAR studies of a HTS hit, Bioorg Med Chem Lett, 21, 417, 10.1016/j.bmcl.2010.10.126

Honda, 2011, Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)- dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent, Bioorg Med Chem Lett, 21, 2188, 10.1016/j.bmcl.2011.03.018

Illig, 2011, Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate. 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)-acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141), J Med Chem, 54, 7860, 10.1021/jm200900q

Dow, 2009, Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part 1: Potent, orally-active 1,4-disubstituted imidazoles, Bioorg Med Chem Lett, 19, 5351, 10.1016/j.bmcl.2009.07.130

Wu, 2009, Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice, J Med Chem, 52, 4496, 10.1021/jm900471u

Kim, 2009, Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists, Bioorg Med Chem Lett, 19, 142, 10.1016/j.bmcl.2008.10.130

He, 2010, Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists, Bioorg Med Chem Lett, 20, 1913, 10.1016/j.bmcl.2010.01.154

Liu, 2010, Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity, Bioorg Med Chem Lett, 20, 2074, 10.1016/j.bmcl.2010.02.076

Basu, 2009, Development of CoMFA and CoMSIA models of cytotoxicity data of anti-HIV-1-phenylamino-1H-imidazole derivatives, Eur J Med Chem, 44, 2400, 10.1016/j.ejmech.2008.09.043

Edwards, 2011, HPV episome levels are potently decreased by pyrrole-imidazole polyamides, Antiviral Res, 91, 177, 10.1016/j.antiviral.2011.05.014

Chong, 2012, Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase, J Med Chem, 55, 10601, 10.1021/jm301294g

Zhan, 2009, Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors, Bioorg Med Chem, 17, 5775, 10.1016/j.bmc.2009.07.028

Le, 2010, Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators, Bioorg Med Chem Lett, 20, 5909, 10.1016/j.bmcl.2010.07.081

Jia, 2009, Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols, Arch Pharm, 342, 507, 10.1002/ardp.200900070

Vlahakis, 2009, Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring, Bioorg Med Chem, 17, 2461, 10.1016/j.bmc.2009.01.078

Sun, 2012, Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification, Bioorg Med Chem Lett, 22, 2338, 10.1016/j.bmcl.2012.01.047

Okuda, 2010, Polycyclic N-heterocyclic compounds. Part 64: Synthesis of 5-amino-1,2,6,7-tetrahydrobenzo[f]furo[2,3-c]isoquinolines and related compounds. Evaluation of their bronchodilator activity and effects on lipoprotein lipase mRNA expression, Chem Pharm Bull, 58, 685, 10.1248/cpb.58.685

Watanabe, 2011, Supramolecular ferric porphyrins as cyanide receptors in aqueous solution, ACS Med Chem Lett, 2, 943, 10.1021/ml200231x

Hille, 2011, First selective CYP11B1 inhibitors for the treatment of cortisol-dependent diseases, ACS Med Chem Lett, 2, 2, 10.1021/ml100071j

Moss, 2009, A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties, Bioorg Med Chem Lett, 19, 2206, 10.1016/j.bmcl.2009.02.126

Garton, 2010, Discovery of biaryl inhibitors of H+/K+ ATPase, Bioorg Med Chem Lett, 20, 1049, 10.1016/j.bmcl.2009.12.040

Lee, 2009, (2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors, Bioorg Med Chem Lett, 19, 1329, 10.1016/j.bmcl.2009.01.060

Bhabak, 2011, Inhibition of peroxynitrite- and peroxidase-mediated protein tyrosine nitration by imidazole-based thiourea and selenourea derivatives, Org Biomol Chem, 9, 7343, 10.1039/c1ob05773a

Joseph, 2011, Ion and molecular recognition by lower rim 1,3-di-conjugates of calix[4]arene as receptors, Chem Rev, 111, 4658, 10.1021/cr1004524

McConnell, 2012, Heteroditopic receptors for ion-pair recognition, Angew Chem Int Ed Engl, 51, 5052, 10.1002/anie.201107244

Nishijima, 2010, Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content, Bioorg Med Chem, 18, 978, 10.1016/j.bmc.2009.07.018

León, 2010, Zinc-imidazole negative staining of chromosomal-sized DNA molecules in agarose minigels, Anal Biochem, 402, 96, 10.1016/j.ab.2010.02.038

Zhang, 2009, (Thio)urea organocatalysis-What can be learnt from anion recognition?, Chem Soc Rev, 38, 1187, 10.1039/b801793j

Amendola, 2009, Anion receptors that contain metals as structural units, Chem Commun, 45, 513, 10.1039/B808264M

Wang, 2012, A new N-imidazolyl-1,8-naphthalimide based fluorescence sensor for fluoride detection, Org Biomol Chem, 10, 6271, 10.1039/c2ob25903f

Kundu, 2012, Selective recognition of fluoride and acetate by a newly designed ruthenium framework: Experimental and theoretical investigations, Dalton Trans, 41, 4484, 10.1039/c2dt12126c

Jadhav, 2011, Fluorescence sensing of H2PO4− by a imidazolium-based cholestane receptor, Tetrahedron Lett, 52, 1623, 10.1016/j.tetlet.2011.01.107

Xu, 2010, Revisit to imidazolium receptors for the recognition of anions: Highlighted research during 2006-2009, Chem Soc Rev, 39, 1457, 10.1039/b918937h

Chen, 2010, Thin-film formation of imidazolium-based conjugated polydiacetylenes and their application for sensing anionic surfactants, Angew Chem Int Ed Engl, 49, 1422, 10.1002/anie.200905041

Vaijayanthi, 2012, Progress and prospects of pyrrole-imidazole polyamide-fluorophore conjugates as sequence-selective DNA probes, ChemBioChem, 13, 2170, 10.1002/cbic.201200451

Kim, 2011, Unique X-ray sheet structure of 1,8-bis(imidazolium) anthracene and its application as a fluorescent probe for DNA and DNase, Org Lett, 13, 1314, 10.1021/ol103166q

Chavda, 2011, Hx, a novel fluorescent, minor groove and sequence specific recognition element: Design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/ pyrrole-containing polyamides, Biochemistry, 50, 3127, 10.1021/bi102028a

Wang, 2010, Aminonaphthalimide-based imidazolium podands for turn-on fluorescence sensing of nucleoside polyphosphates, Org Biomol Chem, 8, 2923, 10.1039/c004148c

Jung, 2012, Recognition of myo-inositol 1,4,5-trisphosphate using a fluorescent imidazolium receptor, Chem Commun, 48, 7928, 10.1039/c2cc33717g

Fujishima, 2012, Ligand-directed acyl imidazole chemistry for labeling of membrane-bound proteins on live cells, J Am Chem Soc, 134, 3961, 10.1021/ja2108855

Hua, 2012, Perylene ligand wrapping G-quadruplex DNA for label-free fluorescence potassium recognition, Biosens Bioelectron, 38, 396, 10.1016/j.bios.2012.06.042

Bian, 2011, Imidazole-bearing tetraphenylethylene: Fluorescent probe for metal ions based on AIE feature, New J Chem, 35, 1667, 10.1039/c1nj20122k

Wang, 2010, Rational design of fluorescent bioimaging probes by controlling the aggregation behavior of squaraines: A special effect of ionic liquid pendants, Chem Eur J, 16, 5129, 10.1002/chem.200903492

Chong, 2010, Synthesis and characterization of degradable water-soluble fluorescent polymers, Macromolecules, 43, 10196, 10.1021/ma102159c

Majouga, 2012, Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: Synthetic and biological studies, Tetrahedron Lett, 53, 51, 10.1016/j.tetlet.2011.10.118

Alfonso, 2011, A simple but effective dual redox and fluorescent ion pair receptor based on a ferrocene-imidazopyrene dyad, Org Lett, 13, 2078, 10.1021/ol2004935