Biến chứng từ Xạ trị cơ thể chính xác trong điều trị ung thư phổi

Cancers - Tập 7 Số 2 - Trang 981-1004
Kylie H. Kang1, Christian C. Okoye2, Ravi B. Patel3, Shankar Siva4, Tithi Biswas5, Rodney J. Ellis6, Min Yao7, Mitchell Machtay8, Simon S. Lo9
1School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
2Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
3Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
4Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. [email protected].
5Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
6Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
7Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
8Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
9Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].

Tóm tắt

Xạ trị cơ thể chính xác (SBRT) đã trở thành một phương pháp điều trị tiêu chuẩn cho ung thư phổi không tế bào nhỏ (NSCLC) giai đoạn sớm, không có hạch bạch huyết ở những bệnh nhân không thể phẫu thuật vì lý do y tế hoặc từ chối phẫu thuật cắt bỏ. SBRT có tỷ lệ kiểm soát tại chỗ cao và có hồ sơ độc tính thuận lợi so với các phương pháp phẫu thuật và không phẫu thuật khác. Với tỷ lệ kiểm soát khối u xuất sắc và việc sử dụng SBRT ngày càng tăng, những nỗ lực gần đây đã tập trung vào việc hạn chế độc tính trong khi mở rộng điều trị cho những bệnh nhân ngày càng phức tạp. Chúng tôi xem xét các độc tính từ SBRT cho ung thư phổi, bao gồm đường hô hấp trung tâm, thực quản, mạch máu (ví dụ, động mạch chủ), nhu mô phổi (ví dụ, viêm phổi do xạ trị) và độc tính từ thành ngực, cũng như các bệnh lý thần kinh do bức xạ (ví dụ, đám rối brachial, dây thần kinh lang thang và dây thần kinh thanh quản quay). Chúng tôi tóm tắt các đặc điểm liên quan đến bệnh nhân, khối u, đặc tính liều lượng của những độc tính này, xem xét các hạn chế liều đã được công bố và đề xuất các chiến lược để giảm thiểu các biến chứng này.

Từ khóa

#Xạ trị cơ thể chính xác #ung thư phổi không tế bào nhỏ #độc tính #viêm phổi do xạ trị #thần kinh do bức xạ

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