Comparison of the effects of morphine administered by constant-rate intravenous infusion or intermittent intramuscular injection in dogs

Journal of the American Veterinary Medical Association - Tập 218 Số 6 - Trang 884-891 - 2001
Anthony N Lucas1, Ava M. Firth, GA Anderson, J. Vine, Glenn A. Edwards
1Veterinary Clinic and Hospital, School of Veterinary Science, University of Melbourne, Werribee, Victoria, Australia.

Tóm tắt

AbstractObjective—To compare physiologic and analgesic effects of morphine when given by IV constant-rate infusion or by IM injection to dogs undergoing laparotomy and to determine pharmacokinetics of morphine in dogs following IV constant-rate infusion.Design—Prospective randomized controlled trial.Animals—20 dogs.Procedure—Dogs undergoing laparotomy were treated with morphine beginning at the time of anesthetic induction. Morphine was administered by IV infusion (0.12 mg/kg/h [0.05 mg/lb/h] of body weight) or by IM injection (1 mg/kg [0.45 mg/lb]) at induction and extubation and every 4 hours thereafter. Treatments continued for 24 hours after extubation.Results—Blood gas values did not indicate clinically significant respiratory depression in either group, and degree of analgesia (determined as the University of Melbourne Pain Scale score) and incidence of adverse effects (panting, vomiting, defecation, and dysphoria) were not significantly different between groups. Dogs in both groups had significant decreases in mean heart rate, rectal temperature, and serum sodium and potassium concentrations, compared with preoperative values. Mean ± SEM total body clearance of morphine was 68 ± 6 ml/min/kg (31 ± 3 ml/min/lb). Mean steady-state serum morphine concentration in dogs receiving morphine by constant-rate infusion was 30 ± 2 ng/ml.Conclusions and Clinical Relevance—Results indicated that administration of morphine as a constantrate IV infusion at a dose of 0.12 mg/kg/h induced effects similar to those obtained with administration at a dose of 1 mg/kg, IM, every 4 hours in dogs undergoing laparotomy. Panting was attributed to an opioidinduced resetting of the hypothalamic temperature set point, rather than respiratory depression. (J Am Vet Med Assoc2001;218:884–891)

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Tài liệu tham khảo

Papich MG, 2000, Vet Clin North Am Small Animal Pract, 30, 815, 10.1016/S0195-5616(08)70009-3

Dohoo S, 1996, Can Vet J, 37, 546

Booth N. Neuroleptanalgesics, narcotic analgesics, and analgesic antagonists. In: Booth N, McDonald L, eds. Veterinary pharmacology and therapeutics. 6th ed. Ames, Iowa: Iowa State University Press, 1988;290-328.

10.2460/ajvr.2000.61.24

Dohoo S, 1994, J Vet Pharmacol Ther, 17, 426, 10.1111/j.1365-2885.1994.tb00273.x

Robinson E, 1988, Am J Vet Res, 49, 1699

Dahlstrom B, 1982, Clin Pharmacokinet, 7, 266, 10.2165/00003088-198207030-00006

Gourlay G, 1986, Anesthesiology, 64, 322, 10.1097/00000542-198603000-00004

Firth A, 1999, J Am Vet Med Assoc, 214, 651, 10.2460/javma.1999.214.05.651

1997, NC: SAS Institute Inc, 571

Milne R, 1996, Drug Metabol Rev, 28, 345, 10.3109/03602539608994011

Reisine T, 1996, New York: McGraw Hill Book Co, 521

Martin WR, 1983, Pharmacol Rev, 35, 283

Martin WR, 1961, J Pharmacol Exp Ther, 133, 262

Martin WR, 1963, J Pharmacol Exp Ther, 146, 385

10.1146/annurev.pa.28.040188.002241

Fox S, 1994, Australia: University of Sydney Post Graduate Committee in Veterinary Science, 87

10.1053/rvsc.1998.0293

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Thông tin xuất bản

Journal of the American Veterinary Medical Association

Tập 218 Số 6

884-891

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