Comparison of the Spectrum of Radiologic and Clinical Manifestations of Pulmonary Disease Caused by Mycobacterium avium Complex and Mycobacterium xenopi

Canadian Association of Radiologists Journal - Tập 65 - Trang 207-213 - 2014
Maria C. Carrillo1,2, Demetris Patsios1,2, Ute Wagnetz1,2, Frances Jamieson3,4, Theodore K. Marras5,6
1Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
2Department of Medical Imaging, University of Toronto, Ontario, Canada
3Public Health Ontario, Toronto, Ontario, Canada
4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
5Department of Medicine, Division of Respirology, University Health Network, Toronto, Ontario, Canada
6Department of Medicine, Division of Respirology, University of Toronto, Toronto, Ontario, Canada

Tóm tắt

Aim Mycobacterium xenopi is described with upper lobe cavitation (“fibrocavitary” pattern), whereas the Mycobacterium avium complex (MAC) is described with bronchiectasis and centrilobular nodules (“nodular bronchiectasis”). We retrospectively described and compared computed tomography (CT) chest manifestations of disease caused by MAC and M xenopi. Materials and Methods We reviewed patients who had either MAC or M xenopi lung disease and who had CTs between January 2002 and December 2003. Clinical data were recorded, and the patterns on chest CTs were categorized as “fibrocavitary,” “nodular bronchiectatic,” and “unclassified.” Results There were 74 patients; 50 with MAC and 24 with M xenopi. The patients with MAC were older (mean 69 vs 58 years; P = .007). Patients with M xenopi more often had emphysema (50% vs 20%; P = .02), cavities (46% vs 16%; P = .01), and nodules ≤5 mm (88% vs 58%; P = .02). M xenopi cases more commonly had a fibrocavitary radiologic pattern (33% vs 18%), with no statistically significant difference ( P = .24). MA C was more often associated with a nodular bronchiectatic pattern (68% MAC vs 4% M xenopi; P < .0001). Sixty-three percent of patients with M xenopi had a pattern that was predominantly randomly distributed nodules (11/15 [73%]) or consolidation and/or ground-glass opacities (4/15 [27%]). Conclusion Compared with MAC, patients with M xenopi infection develop more cavities and more nodules, and they less often have a predominant nodular bronchiectatic pattern. Although a predominantly cavitary pattern appears to be more common with M xenopi, the majority of patients with M xenopi had CT patterns of random nodules or consolidation and/or ground-glass opacities rather than classically described findings.

Tài liệu tham khảo

10.1016/S0272-5231(02)00019-9 10.1136/thx.2006.070797 10.1136/thx.2008.096842 10.1136/thx.39.5.376 10.1164/rccm.200604-571ST 10.1111/j.1365-2672.2009.04161.x 10.1378/chest.11-0089 10.1148/radiol.2313030833 Varadi R.G., 2009, Int J Tuberc Lung Dis, 13, 1210 10.1007/s00330-001-1282-1 10.1259/bjr.75.892.750340 10.1097/00004728-199803000-00012 10.1148/radiographics.19.6.g99no101487 10.1136/thx.38.5.373 10.1148/radiology.191.2.8153304 10.1007/s00408-010-9241-8 10.1016/S1010-7940(01)00720-5 10.1378/chest.101.6.1605 10.1136/thx.2005.046631 10.1056/NEJM198909283211310 10.1378/chest.130.4.1234
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Canadian Association of Radiologists Journal

Tập 65

207-213

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