Comparison of multiplexed reduced representation bisulfite sequencing (mRRBS) with the 450K Illumina Human BeadChip: from concordance to practical applications for methylomic profiling in epigenetic epidemiologic studies

Springer Science and Business Media LLC - Tập 6 - Trang 1-2 - 2013
Juan J Carmona1,2,3, Benedetta Izzi4,5, Allan C Just1, Jitendra Barupal1, Alexandra M Binder, John Hutchinson6, Oliver Hofmann6, Joel Schwartz1,2,3, Andrea Baccarelli1,2,3,7,8, Karin B Michels3,4,5
1Laboratory of Environmental Epigenetics, Department of Environmental Health, Harvard School of Public Health, Boston, USA
2Exposure, Epidemiology, & Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, USA
3Department of Epidemiology, Harvard School of Public Health, Boston, USA
4Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
5Division of Cancer Epidemiology, Comprehensive Cancer Center Freiburg, Freiburg University, Freiburg, Germany
6Center for Health Bioinformatics, Harvard School of Public Health, Department of Biostatistics &, Program in Quantitative Genomics, Boston, USA
7Dana-Farber/Harvard Cancer Center, Boston, USA
8Harvard/Massachusetts General Hospital Center on Genomics, Vulnerable Populations, and Health Disparities, Boston, USA

Tài liệu tham khảo

Boyle P, Clement K, Gu H, Smith ZD, Ziller M, Fostel JL, Holmes L, Meldrim J, Kelley F, Gnirke A, Meissner A: Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling. Genome Biol. 2012, 13: R92-10.1186/gb-2012-13-10-r92. Touleimat N, Tost J: Complete pipeline for Infinium((R)) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics. 2012, 4: 325-341. 10.2217/epi.12.21.
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