Comparison of Virulence between Seoul Virus Strain SR‐11 and Hantaan Virus Strain 76–118 of Hantaviruses in Newborn Mice

Microbiology and Immunology - Tập 37 Số 7 - Trang 557-562 - 1993
Yung Choon Yoo1, Kumiko Yoshimatsu1, Ryu Yoshida1, Mizuho Tamura1, Ichiro Azuma1, Jiro Arikawa1
1Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido 060, Japan

Tóm tắt

AbstractVirulence of hantavirus strain of SR‐11 Seoul virus and Hantaan 76–118 (HTN) of Hantaan virus were compared. Infections of both strains were lethal in newborn mice. However, inoculum required to cause lethal infection was about 4,000 times higher for strain HTN (1.65 × 103 PFU/mouse/LD50) than for strain SR‐11 (0.36 PFU). Thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. The assay system used for these strains in newborn mice proved to be useful in the study of hantavirus vilurence. Growth curves of the two strains in CV‐7 cell cultures were compared. Strain SR‐11 was shown to have higher activity of virus replication and virus release into the culture fluids than strain HTN. The possibility of a relationship between replication activity and high levels of virulence in mice was suggested.

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Microbiology and Immunology

Tập 37 Số 7

557-562

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