Comparing the RETeval® portable ERG device with more traditional tabletop ERG systems in normal subjects and selected retinopathies
Tóm tắt
Our study aimed to determine if ISCEV standard-like ERGs recorded with the LKC RETeval® portable ERG unit compared to those obtained using the more traditional tabletop unit. ERGs recorded from normal subjects and patients affected with retinal ON and OFF pathway anomalies were compared. Analysis included peak time and amplitude measurements as well as time–frequency domain analysis with the discrete wavelet transform of waveforms obtained with the two systems. Although both systems were similarly able to record reliable and highly reproducible ERG responses, there were major discrepancies in ERG responses between the portable and tabletop units, pointing toward a weaker stimulation of the retinal OFF pathway with the portable RETeval® unit. The portable RETeval® unit appears to be able to record highly reproducible and diagnostically useful clinical ERGs, albeit with some significant differences in waveform composition compared to those obtained with more standard tabletop systems. Given the unknown origin of these waveform discrepancies, if left uncorrected, these differences could potentially lead to erroneous interpretation when used in the clinical context and/or compared to ERGs recorded using more traditional table top units. Clearly, more research is warranted before handheld devices, such as the RETeval®, can be homologated as a diagnostically sound ERG devices.
Tài liệu tham khảo
Robson AG, Frishman LJ, Grigg J, Hamilton R, Jeffrey BG, Kondo M, Li S, McCulloch DL (2022) ISCEV Standard for full-field clinical electroretinography (2022 update). Doc Ophthalmol. https://doi.org/10.1007/s10633-022-09872-0
Tzekov R, Arden GB (1999) The electroretinogram in diabetic retinopathy. Surv Ophthalmol 44(1):53–60
Fukuo M, Kondo M, Hirose A, Fukushima H, Ikesugi K, Sugimoto M, Kato K, Uchigata Y, Kitano S (2016) Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device. Sci Rep 8(6):36591
Maa AY, Feuer WJ, Davis CQ, Pillow EK, Brown TD, Caywood RM et al (2016) A novel device for accurate and efficient testing for vision-threatening diabetic retinopathy. J Diabetes Complicat 30(3):524–532
Al-Otaibi H, Al-Otaibi MD, Khandekar R, Souru C, Al-Abdullah AA, Al-Dhibi H et al (2017) Validity, usefulness and cost of RET eval system for diabetic retinopathy screening. Transl Vis Sci Technol 6(3):3
Grace SF, Lam BL, Feuer WJ, Osigian CJ, Cavuoto KM, Capo H (2017) Nonsedated handheld electroretinogram as a screening test of retinal dysfunction in pediatric patients with nystagmus. J Am Assoc Pediatr Ophthalmol Strabismus [Internet]. [cited 2017 Oct 2]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S1091853117301544
Davis CQ, Kraszewska O, Manning C (2017) Constant luminance (cd·s/m2) versus constant retinal illuminance (Td·s) stimulation in flicker ERGs. Doc Ophthalmol 134(2):75–87
Kato K, Kondo M, Sugimoto M, Ikesugi K, Matsubara H (2015) Effect of pupil size on flicker ERGs recorded with RETeval System: new mydriasis-free full-field ERG system. Investig Opthalmol Vis Sci 56(6):3684
Miura G, Nakamura Y, Sato E, Yamamoto S. Effects of cataracts on flicker electroretinograms recorded with RETevalTM system: new mydriasis-free ERG device. BMC Ophthalmol [Internet]. 2016 [cited 2016 Jul 4];16(1). Available from: http://www.biomedcentral.com/1471-2415/16/22
Nakamura N, Fujinami K, Mizuno Y, Noda T, Tsunoda K (2016) Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device. Clin Ophthalmol 10:1175–1185
Kato K, Kondo M, Nagashima R, Sugawara A, Sugimoto M, Matsubara H, McCulloch DL, Ikesugi K (2017) Factors affecting mydriasis-free flicker ERGs recorded with real-time correction for retinal illuminance: study of 150 young healthy subjects. Invest Ophthalmol Vis Sci 58(12):5280–5286. https://doi.org/10.1167/iovs.17-22587
Soekamto CD, Gupta R, Keck KM (2021) Using the RETeval device in healthy children to establish normative electroretinogram values. J Pediatr Ophthalmol Strabismus 58(1):17–22
Osigian CJ, Grace SF, Cavuoto KM, Feuer WJ, Tavakoli M, Saksiriwutto P, Liu M, Capo H, Lam BL (2019) Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram. J AAPOS 23(1):34.e1-34.e5
Kimia R, Hansen RH, Moskowitz A, Fulton AB (2017) Comparison of ERG responses obtained using a portable device and a conventional recording system. Investig Ophthalmol Vis 58:4887
Liu H, Ji X, Dhaliwal S, Rahman SN, McFarlane M, Tumber A, Locke J, Wright T, Vincent A, Westall C (2018) Evaluation of light- and dark-adapted ERGs using a mydriasis-free, portable system: clinical classifications and normative data. Doc Ophthalmol 137(3):169–181
Carter P, Gordon-Reid A, Shawkat F, Self JE (2021) Comparison of the handheld RETeval ERG system with a routine ERG system in healthy adults and in paediatric patients. Eye (Lond) 35(8):2180–2189
Kim BG, Chang IB, Jeong KD, Park JY, Kim JS, Hwang JH (2019) Comparison of electroretinographic measurements between tabletop and handheld stimulators in healthy subjects. Doc Ophthalmol 139(1):1–9
Gauvin M, Dorfman AL, Lachapelle P (2018) Recording and analysis of the human clinical electroretinogram. Methods Mol Biol 1715:313–325
Dryja TP, McGee TL, Berson EL, Fishman GA, Sandberg MA, Alexander KR et al (2005) Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Proc Natl Acad Sci U S A 102(13):4884–4889
Gregg RG, Kamermans M, Klooster J, Lukasiewicz PD, Peachey NS, Vessey KA et al (2007) Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness. J Neurophysiol 98(5):3023–3033
Langrová H, Gamer D, Friedburg C, Besch D, Zrenner E, Apfelstedt-Sylla E (2002) Abnormalities of the long flash ERG in congenital stationary night blindness of the Schubert-Bornschein type. Vis Res 42(11):1475–1483
Miyake Y, Yagasaki K, Horiguchi M, Kawase Y (1987) On-and off-responses in photopic electroretinogram in complete and incomplete types of congenital stationary night blindness. Jpn J Ophthalmol 31(1):81–87
Pusch CM, Zeitz C, Brandau O, Pesch K, Achatz H, Feil S et al (2000) The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Nat Genet 26(3):324
Quigley M, Roy M-S, Barsoum-Homsy M, Chevrette L, Jacob J-L, Milot J (1996) On-and off-responses in the photopic electroretinogram in complete-type congenital stationary night blindness. Doc Ophthalmol 92(3):159–165
Bech-Hansen NT, Naylor MJ, Maybaum TA, Sparkes RL, Koop B, Birch DG et al (2000) Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness. Nat Genet 26(3):319
Heckenlively JR, Martin DA, Rosenbaum AL (1983) Loss of electroretinographic oscillatory potentials, optic atrophy, and dysplasia in congenital stationary night blindness. Am J Ophthalmol 96(4):526–534
Rufiange M, Dassa J, Dembinska O, Koenekoop RK, Little JM, Polomeno RC et al (2003) The photopic ERG luminance-response function (photopic hill): method of analysis and clinical application. Vis Res 43(12):1405–1412
Miyake Y, Horiguchi M, Suzuki S, Kondo M, Tanikawa A (1997) Complete and incomplete type congenital stationary night blindness (CSNB) as a model of “OFF-retina” and “ON-retina.” In: Degenerative retinal diseases. Springer, 31–41
Lachapelle P, Little JM, Polomeno RC (1983) The photopic electroretinogram in congenital stationary night blindness with myopia. Invest Ophthalmol Vis Sci 24:442–450
Garon M-L, Dorfman AL, Racine J, Koenekoop RK, Little JM, Lachapelle P (2014) Estimating ON and OFF contributions to the photopic hill: normative data and clinical applications. Doc Ophthalmol 129(1):9–16
Lachapelle P, Rousseau S, McKerral M, Benoit J, Polomeno RC, Koenekoop RK et al (1998) Evidence supportive of a functional discrimination between photopic oscillatory potentials as revealed with cone and rod mediated retinopathies. Doc Ophthalmol 95(1):35–54
Gauvin M, Little JM, Lina J-M, Lachapelle P (2015) Functional decomposition of the human ERG based on the discrete wavelet transform. J Vis 15(16):14
You JY, Dorfman AL, Sun V, Gauvin M, Vatcher D, Polomeno RC, Koenekoop RK, Lachapelle P (2016) Comparing the RETeval portable ERG device with a more traditional ERG system. Doc Ophthalmol 133:38
Garon M-L, Rufiange M, Hamilton R, McCulloch DL, Lachapelle P (2010) Asymmetrical growth of the photopic hill during the light adaptation effect. Doc Ophthalmol 121(3):177–187
Rufiange M, Rousseau S, Dembinska O, Lachapelle P (2002) Cone-dominated ERG luminance–response function: the photopic hill revisited. Doc Ophthalmol 104(3):231–248
Gauvin M, Lina J-M, Lachapelle P (2014) Advance in ERG analysis: from peak time and amplitude to frequency, power, and energy. BioMed Res Int 2014:1–11
Gauvin M, Sustar M, Little JM, Brecelj J, Lina J-M, Lachapelle P (2017) Quantifying the ON and OFF contributions to the flash ERG with the discrete wavelet transform. Transl Vis Sci Technol 6(1):3
Wali N, Leguire LE (1992) The photopic hill: a new phenomenon of the light adapted electroretinogram. Doc Ophthalmol 80:335–342
Ueno S, Kondo M, Niwa Y, Terasaki H, Miyake Y (2004) Luminance dependence of neural components that underlies the primate photopic electroretinogram. Invest Ophthalmol Vis Sci 45(3):1033–1040
Asakawa K, Amino K, Iwase M, Kusayanagi Y, Nakamura A, Suzuki R et al (2017) New mydriasis-free electroretinogram recorded with skin electrodes in healthy subjects. BioMed Res Int 2017:1–7
Wu Z, Hadoux X, Hui F, Sarossy MG, Crowston JG (2016) Photopic negative response obtained using a handheld electroretinogram device: determining the optimal measure and repeatability. Transl Vis Sci Technol 5(4):8
Tang J, Edwards T, Crowston JG, Sarossy M (2014) The test-retest reliability of the photopic negative response (PhNR). Transl Vis Sci Technol 3(6):1
Kojima M, Zrenner E (1978) Off-components in response to brief light flashes in the oscillatory potential of the human electroretinogram. Albrecht Von Graefes Arch Für Klin Exp Ophthalmol 206(2):107–120
Nagata M (1963) Studies on the photopic ERG of the human retina. Jpn J Ophthalmol 7:96–124
Rousseau S, McKerral M, Lachapelle P (1995) The i-wave: bridging flash and pattern electroretinography. Electroencephalogr Clin Neurophysiol Suppl 46:165–171
Sachidanandam R, Khetan V, Sen P (2015) Comparison between fullfield electroretinography obtained from handheld and tabletop devices in normal subjects. Can J Ophthalmol J Can Ophtalmol 50(2):166–171
Hamilton R, Bees MA, Chaplin CA, McCulloch DL (2007) The luminance-response function of the human photopic electroretinogram: a mathematical model. Vis Res 47:2968–2972
Rufiange M, Dumont M, Lachapelle P (2005) Modulation of the human photopic ERG luminance-response function with the use of chromatic stimuli. Vis Res 45(17):2321–2330
Lachapelle P, Molotchnikoff S (1986) Components of the electroretinogram: a reappraisal. Doc Ophthalmol 63(4):337–348
-RETeval device user manual. LKC Technlogies January 7, 2022. (https://f.hubspotusercontent40.net/hubfs/8952491/User%20Manuals/96-023%20RETeval%20Device%20User%20Manual%20January%207%202022.pdf)