Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

2001, Cancer genetics., Nature, 411, 336, 10.1038/35077207

2003, Gene silencing in cancer in association with promoter hypermethylation., N Engl J Med, 349, 2042, 10.1056/NEJMra023075

2006, The consensus coding sequences of human breast and colorectal cancers., Science, 314, 268, 10.1126/science.1133427

1993, Number of cpg islands and genes in human and mouse., Proc Natl Acad Sci U S A, 90, 11995, 10.1073/pnas.90.24.11995

2000, Aberrant CpG-island methylation has non-random and tumour-type-specific patterns., NatGenet, 24, 132

2004, Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach., Cancer Cell, 6, 361, 10.1016/j.ccr.2004.08.029

2005, Distinct epigenetic changes in the stromal cells of breast cancers., Nat Genet, 37, 899, 10.1038/ng1596

2006, Evidence for an instructive mechanism of de novo methylation in cancer cells., Nat Genet, 38, 149, 10.1038/ng1719

2003, Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases., Hum Mol Genet, 12, 2209, 10.1093/hmg/ddg226

2002, A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer., Nat Genet, 31, 141, 10.1038/ng892

1999, Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification., Cancer Res, 59, 2307

2005, Detection and interpretation of altered methylation patterns in cancer cells., Nat Rev Cancer, 5, 223, 10.1038/nrc1571

2005, Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells., Nat Genet, 37, 853, 10.1038/ng1598

2002, DNMT1 and DNMT3b cooperate to silence genes in human cancer cells., Nature, 416, 552, 10.1038/416552a

2003, GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer., Mol Cell Biol, 23, 8429, 10.1128/MCB.23.23.8429-8439.2003

2003, Epigenetic inactivation of CHFR in human tumors., Proc Natl Acad Sci U S A, 100, 7818, 10.1073/pnas.1337066100

2006, Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival., Proc Natl Acad Sci U S A, 103, 14080, 10.1073/pnas.0604602103

2007, DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells., J Cell Biol, 176, 565, 10.1083/jcb.200610062

2002, 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy., Oncogene, 21, 5483, 10.1038/sj.onc.1205699

1985, Altering gene expression with 5-azacytidine., Cell, 40, 485, 10.1016/0092-8674(85)90192-8

1999, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer., Nat Genet, 21, 103, 10.1038/5047

1996, Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands., Proc Natl Acad Sci U S A, 93, 9821, 10.1073/pnas.93.18.9821

2002, Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma., Cancer Cell, 2, 485, 10.1016/S1535-6108(02)00215-5

1998, Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region., Oncogene, 16, 1009, 10.1038/sj.onc.1201618

2001, Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling., Dev Cell, 1, 795, 10.1016/S1534-5807(01)00091-0

2001, Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta., Dev Cell, 1, 783, 10.1016/S1534-5807(01)00092-2

2001, neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis., Dev Cell, 1, 807, 10.1016/S1534-5807(01)00093-4

2005, Notch signals control the fate of immature progenitor cells in the intestine., Nature, 435, 964, 10.1038/nature03589

2005, Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells., Nature, 435, 959, 10.1038/nature03659

2005, Self-renewal and cancer of the gut: Two sides of a coin., Science, 307, 1904, 10.1126/science.1104815

2003, Fox's in development and disease., Trends Genet, 19, 339, 10.1016/S0168-9525(03)00111-2

2004, Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development., Hum Mol Genet, 13, 1171, 10.1093/hmg/ddh124

2001, The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome., Nat Genet, 27, 159, 10.1038/84781

1993, Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis., Nature, 363, 558, 10.1038/363558a0

1993, Hypermutability and mismatch repair deficiency in RER+ tumor cells., Cell, 75, 1227, 10.1016/0092-8674(93)90331-J

1998, Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma., Proc Natl Acad Sci U S A, 95, 6870, 10.1073/pnas.95.12.6870

1999, CpG island methylator phenotype in colorectal cancer., Proc Natl Acad Sci U S A, 96, 8681, 10.1073/pnas.96.15.8681

2006, CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer., Nat Genet, 38, 787, 10.1038/ng1834

2005, Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon., Genes Dev, 19, 311, 10.1101/gad.1260605

1994, Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma., Proc Natl Acad Sci U S A, 91, 9700, 10.1073/pnas.91.21.9700

2004, Epigenetics in human disease and prospects for epigenetic therapy., Nature, 429, 457, 10.1038/nature02625

2002, Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors., Nat Genet, 32, 453, 10.1038/ng1007

1996, A language for data analysis and graphics., J Comput Graphical Stat, 5, 299

2004, Bioconductor: Open software development for computational biology and bioinformatics., Genome Biol, 5, R80, 10.1186/gb-2004-5-10-r80

2003, Normalization of cDNA microarray data., Methods, 31, 265, 10.1016/S1046-2023(03)00155-5

2003, Statistical issues in cDNA microarray data analysis., Methods Mol Biol, 224, 111

1997, BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines., Cancer Res, 57, 300

2004, Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer., Nat Genet, 36, 417, 10.1038/ng1330