Phân tích transcriptome so sánh để xem xét giả định rằng các PAHs genotoxic có tác dụng qua một cơ chế chung

Ba Q, Li J, Huang C et al (2014) Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling. Environ Health Perspect 123(3):246–254 Bostrom CE, Gerde P, Hanberg A et al (2002) Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect 110(3):451–488 CCME (2010) Canadian soil quality guidelines: carcinogenic and other polycyclic aromatic hydrocarbons (PAHs) (environmental and human effects), vol PN 1445. Canadian Council of Ministers of the Environment Culp S, Gaylor D, Sheldon W, Goldstein L, Beland F (1998) A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay. Carcinogenesis 19(1):117–124 Davis JA, Gift JS, Zhao QJ (2011) Introduction to benchmark dose methods and U.S. EPA’s benchmark dose software (BMDS) version 2.1.1. Toxicol Appl Pharmacol 254:181–191. doi:10.1016/j.taap.2010.10.016 Donald C, Cooper C, Harris-Hooker S, Emmett N, Scanlon M, Dr Cooke (2001) Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer. Cell Mol Biol 47(6):1033–1038 EFSA (2008) Polycyclic aromatic hydrocarbons in food. Scientific opinion of the panel on contaminants in the food chain. EFSA J 742:1–114 Godschalk RW, Van Schooten FJ, Bartsch H (2003) A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds. J Biochem Mol Biol 36(1):1–11 Hakura A, Tsutsui Y, Sonoda J et al (1998) Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse). Mutat Res 398(1–2):123–130 Halappanavar S, Wu D, Williams A et al (2011) Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage. Toxicology 285:133–141 Hanahan D, Weinberg R (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674 Harrigan J, McGarrigle B, Sutter T, Olson J (2006) Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro 20(4):426–438 Health Canada (2010) Federal contaminated site risk assessment in Canada part 1: guidance on human health preliminary quantitative risk assessment (PQRA), Version 2.0, H128-1/11-632E-PDF Health Protection Agency (2010) Contaminated land information sheet—polycyclic aromatic hydrocarbons (PAHs). Health Protection Agency, Chilton Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1):44–57 IARC (2010) Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans 92F Jung KH, Kim JK, Noh JH et al (2013) Characteristic molecular signature for the early detection and prediction of polycyclic aromatic hydrocarbons in rat liver. Toxicol Lett 216(1):1–8. doi:10.1016/j.toxlet.2012.11.001 Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27–30 Kroese E, Muller J, Mohn G, Dortant P, Wester P (2001) Tumorigenic effects in Wistar rats orally administered benzo[a]pyrene for two years (gavage studies). Implications for human cancer risks associated with oral exposure to polycyclic aromatic hydrocarbons. RIVM Report 658603010 Labib S, Yauk C, Williams A et al (2012) Sub-chronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis. Toxicol Sci 129(1):213–224 Labib S, Guo C, Williams A, Yauk C, White P, Halappanavar S (2013) Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: relevance to human cancer risk. Toxicol Appl Pharmacol 273(1):269–280 Laupeze B, Amiot L, Sparfel L, Le Ferrec E, Fauchet R, Fardel O (2002) Polycyclic aromatic hydrocarbons affect functional differentiation and maturation of human monocyte-derived dendritic cells. J Immunol 168(6):2652–2658. doi:10.4049/jimmunol.168.6.2652 Lecureur V, Ferrec EL, N’diaye M et al (2005) ERK-dependent induction of TNFα expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Lett 579(9):1904–1910 Lemieux C, Douglas G, Gingerich J et al (2011) Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse. Environ Mol Mutagen 52(9):756–765 Lu H, Ouyang W, Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res 4(4):221–233. doi:10.1158/1541-7786.mcr-05-0261 Malik A, Williams A, Lemieux C, White P, Yauk C (2012) Hepatic mRNA, microRNA, and miR-34a-Target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation. Environ Mol Mutagen 53(1):10–21 Malik AI, Rowan-Carroll A, Williams A et al (2013) Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a, h]anthracene. Mutagenesis 28(5):543–554. doi:10.1093/mutage/get031 Mayati A, Levoin N, Paris H et al (2012) Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2 adrenergic receptor/adenylyl cyclase/Epac-1/IP3 pathway in endothelial cells. J Biol Chem 287(6):4041–4052. doi:10.1074/jbc.M111.319970 Moffat I, Chepelev NL, Labib S et al (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol 45(1):1–43. doi:10.3109/10408444.2014.973934 Mosesson Y, Mills GB, Yarden Y (2008) Derailed endocytosis: an emerging feature of cancer. Nat Rev Cancer 8(11):835–850 OECD (2011) Test No. 488: transgenic rodent somatic and germ cell gene mutation assays OECD guidelines for the testing of chemicals, Section 4: health effects. Organisation for Economic Co-operation and Development, p 16 Phillips DH, Arlt VM (2007) The 32P-postlabeling assay for DNA adducts. Nat Protoc 2(11):2772–2781 Phillips D, Arlt V (2014) 32P-postlabeling analysis of DNA Adducts. In: Keohavong P, Grant SG (eds) Molecular toxicology protocols. Methods in molecular biology, vol 1105. Humana Press, New York, pp 127–138 Pottenger LH, Carmichael N, Banton MI et al (2009) ECETOC workshop on the biological significance of DNA adducts: summary of follow-up from an expert panel meeting. Mutat Res 678(2):152–157. doi:10.1016/j.mrgentox.2009.07.006 Prevarskaya N, Skryma R, Shuba Y (2011) Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer 11(8):609–618 R Development Core Team (2010) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna Renault D, Brault D, Thybaud V (1997) Effect of ethylnitrosourea and methyl methanesulfonate on mutation frequency in Muta™Mouse germ cells seminiferous tubule cells and epididymis spermatozoa. Mutat Res 388:145–153 Resende R, Andrade L, Oliveira A, Guimaraes E, Guatimosim S, Leite MF (2013) Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus. Cell Commun Signal 11(1):14 Song M-K, Song M, Choi H-S, Kim Y-J, Park Y-K, Ryu J-C (2012) Identification of molecular signatures predicting the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). Toxicol Lett 212(1):18–28. doi:10.1016/j.toxlet.2012.04.013 Sparfel L, Pinel-Marie M-L, Boize M et al (2010) Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci 114(2):247–259. doi:10.1093/toxsci/kfq007 Tilton SC, Siddens LK, Krueger SK et al (2015) Mechanism-based classification of PAH mixtures to predict carcinogenic potential. Toxicol Sci 146(1):135–145. doi:10.1093/toxsci/kfv080 USEPA (2010) DRAFT Development of a relative potency factor approach for polycyclic aromatic hydrocarbon mixtures. In support of summary information on the integrated risk information system (IRIS) EPA/635/R-08/012A USEPA (2011) IRIS Toxicological reviews of chemicals, Washington, DC USEPA (2012) Benchmark dose technical guidance. EPA/100/R-12/001 van Grevenynghe J, Rion S, Le Ferrec E et al (2003) Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages. J Immunol 170(5):2374–2381 Wenzel-Hartung R, Brune H, Grimmer G, Germann P, Timm J, Wosniok W (1990) Evaluation of the carcinogenic potency of 4 environmental polycyclic aromatic compounds following intrapulmonary application in rats. Exp Pathol 40(4):221–227 Weyand EH, Chen YC, Wu Y, Koganti A, Dunsford HA, Rodriguez LV (1995) Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: benzo[a]pyrene vs manufactured gas plant residue. Chem Res Toxicol 8(7):949–954 Zuo J, Brewer D, Arlt V, Cooper C, Phillips D (2014) Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. BMC Genomics 15(1):880