Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor

Pathology International - Tập 62 Số 2 - Trang 120-126 - 2012
Junjeong Choi1, Ja Seung Koo2
1Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, South Korea
2Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea

Tóm tắt

We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.

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Pathology International

Tập 62 Số 2

120-126

Thông tin tác giả