Yasuhiro Yoshida1,2,3,4,5, K. Nagakane1,2,3,4,5, R. Fukuda1,2,3,4,5, Y. Nakayama1,2,3,4,5, M. Okazaki1,2,3,4,5, Hideaki Shintani1,2,3,4,5, Satoshi Inoue1,2,3,4,5, Yoh‐ichi Tagawa1,2,3,4,5, Kazuomi Suzuki1,2,3,4,5, Jan De Munck1,2,3,4,5, Bart Van Meerbeek1,2,3,4,5
1Department of Biomaterials Science, Hiroshima University Graduate School of Biomaterials Science, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan;
2Department of Biomaterials, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan
3Department of Operative Dentistry and Dental Materials, Hiroshima University Graduate School of Biomaterials Science, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan;
4Research Center for Biomedical Engineering, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan;
5Research Planning Department, Toray Research Center, Inc., Sonoyama 3-3-7, Otsu, Shiga 520-8567, Japan;
Tóm tắt
Mild self-etch adhesives demineralize dentin only partially, leaving hydroxyapatite around collagen within a submicron hybrid layer. We hypothesized that this residual hydroxyapatite may serve as a receptor for chemical interaction with the functional monomer and, subsequently, contribute to adhesive performance in addition to micro-mechanical hybridization. We therefore chemically characterized the adhesive interaction of 3 functional monomers with synthetic hydroxyapatite, using x-ray photoelectron spectroscopy and atomic absorption spectrophotometry. We further characterized their interaction with dentin ultra-morphologically, using transmission electron microscopy. The monomer 10-methacryloxydecyl dihydrogen phosphate (10-MDP) readily adhered to hydroxyapatite. This bond appeared very stable, as confirmed by the low dissolution rate of its calcium salt in water. The bonding potential of 4-methacryloxyethyl trimellitic acid (4-MET) was substantially lower. The monomer 2-methacryloxyethyl phenyl hydrogen phosphate (phenyl-P) and its bond to hydroxyapatite did not appear to be hydrolytically stable. Besides self-etching dentin, specific functional monomers have additional chemical bonding efficacy that is expected to contribute to their adhesive potential to tooth tissue.
