Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats

Journal of Diabetes Research - Tập 2016 - Trang 1-5 - 2016
C. Bonaventure1, Theophine Chinwuba Okoye1, Victor Eshu Okpashi2, Christiana Nonye Igwe3, EO Alumanah2
1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
2Department of Biochemistry, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
3Synthetic Organic Chemistry Division, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

Tóm tắt

Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries. Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications. In the present study, the antioxidant effects of metformin (MET), glibenclamide (GLI), and repaglinide (REP) were evaluated in alloxan-induced diabetic rats. The findings from this study may possibly help in understanding the efficacy of these standard drugs in managing the complications arising from diabetes mellitus (DM). Alloxan (130 mg/kg BW) was administered as a single dose to induce diabetes. Four (4) groups of rats (n=6) were used; group 1 served as diabetic control while groups 2, 3, and 4 were the diabetic test groups that received MET (25 mg/kg), GLI (2.5 mg/kg), and REP (0.5 mg/kg), respectively. The result of the study showed significant (p<0.05) improvement in the altered antioxidant enzymes (SOD, CAT) and GSH concentration in diabetic treated rats compared with the diabetic control group. MET and REP produced significant effect on the MDA concentration while GLI showed insignificant reduction in the MDA concentration compared with the diabetic control. Findings from this study suggest that the administration of MET, GLI, and REP exerts significant antioxidant effects in alloxan-induced diabetic rats, thus contributing to the protective effect against oxidative stress-induced damage during diabetic complications.

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Tài liệu tham khảo

2002

10.2337/diabetes.54.suppl_2.s97

10.2337/diabetes.52.1.1

10.1016/j.freeradbiomed.2005.12.018

10.1016/0378-8741(89)90001-9

10.2165/00003088-199630050-00003

10.1111/j.1442-200x.2005.02075.x

10.1056/nejm198805123181903

10.3168/jds.s0022-0302(91)78493-2

1983, Catalase, 673

1959, Microanalysis, 14

10.1080/09553009014552121

10.2337/diabetes.48.1.1

10.1016/j.fct.2004.08.012

10.1900/rds.2010.7.15

1985, Laboratory Investigation, 53, 599

10.1016/j.numecd.2005.05.003

2008, International Journal of Applied Research in Natural Products, 1, 25

2009, African Journal of Traditional, Complementary and Alternative Medicines, 6, 78

2013, Bangladesh Journal of Medical Science, 12, 298, 10.3329/bjms.v12i3.12721

2004, Indian Journal of Experimental Biology, 42, 989

1994, Physiological Reviews, 74, 139, 10.1152/physrev.1994.74.1.139

2011, International Journal of PharmTech Research, 3, 1780

1968, Physiological Reviews, 48, 311, 10.1152/physrev.1968.48.2.311

10.3390/ijms11052056

10.1016/s0008-6363(00)00097-3

10.1002/(sici)1099-0461(2000)14:460;189::aid-jbt262;3.0.co;2-v

10.1021/jf010697n

2005, Biokemistri, 17, 149

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Journal of Diabetes Research

Tập 2016

1-5

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