Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

American Association for the Advancement of Science (AAAS) - Tập 350 Số 6264 - Trang 1084-1089 - 2015
Ayelet Sivan1, Leticia Corrales1, Nathaniel Hubert2, Jason B. Williams1, Keston Aquino-Michaels3, Zachary M. Earley2, Franco W. Benyamin1, Yuk Man Lei2, Bana Jabrì2, Maria‐Luisa Alegre2, Eugene B. Chang2, Thomas F. Gajewski2,1
1Department of Pathology, University of Chicago, Chicago, IL 60637 USA
2Department of Medicine, University of Chicago, Chicago, IL 60637, USA
3Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA

Tóm tắt

Gut microbes affect immunotherapy

The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Although these therapies can cause dramatic tumor regressions in some patients, many patients inexplicably see no benefit. Mice have been used in two studies to investigate what might be happening. Specific members of the gut microbiota influence the efficacy of this type of immunotherapy (see the Perspective by Snyder et al. ). Vétizou et al. found that optimal responses to anticytotoxic T lymphocyte antigen blockade required specific Bacteroides spp. Similarly, Sivan et al. discovered that Bifidobacterium spp. enhanced the efficacy of antiprogrammed cell death ligand 1 therapy.

Science , this issue, p. 1079 and p. 1084 ; see also p. 1031

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Tài liệu tham khảo

10.1056/NEJMoa1003466

10.1056/NEJMoa1305133

10.1038/nature13954

10.1126/scitranslmed.3006504

10.1007/s00262-011-1172-6

10.1097/PPO.0b013e3181eacbd8

10.1126/science.1223490

10.1016/j.chom.2012.09.009

10.1016/j.immuni.2012.07.001

10.1126/science.1240527

10.1126/science.1240537

10.1016/j.cell.2009.09.033

10.1016/j.ijfoodmicro.2009.12.023

10.1128/AEM.01261-07

10.1016/j.earlhumdev.2010.01.002

10.1111/1348-0421.12210

10.1038/nature12726

10.1126/science.1241165

10.1126/science.1198469

Mackey M. F., Gunn J. R., Maliszewsky C., Kikutani H., Noelle R. J., Barth R. J., Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J. Immunol. 161, 2094–2098 (1998).9725199

10.1016/j.immuni.2007.12.016

10.4049/jimmunol.1201271

10.1016/j.imlet.2004.05.003

Pettit A. R., Quinn C., MacDonald K. P., Cavanagh L. L., Thomas G., Townsend W., Handel M., Thomas R., Nuclear localization of RelB is associated with effective antigen-presenting cell function. J. Immunol. 159, 3681–3691 (1997).9378953

10.3389/fimmu.2012.00037

10.1038/ncb1552

10.1128/IAI.00153-07

10.2353/ajpath.2007.070225

10.1002/eji.200535549

10.1056/NEJMoa020177

10.1084/jem.20101159

10.1016/j.immuni.2014.10.017

10.1158/0008-5472.CAN-03-3259

10.1038/nmeth.f.303

10.1038/ismej.2011.139

10.1093/bioinformatics/btp636

10.1128/AEM.00062-07

10.1128/AEM.71.12.8228-8235.2005

10.1093/nar/gkr201

10.1128/IAI.01432-07

10.1371/journal.pone.0129996

10.1111/j.1574-6941.2009.00671.x

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American Association for the Advancement of Science (AAAS)

Tập 350 Số 6264

1084-1089

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