Điều trị phối hợp với Interferon-α2b, Ribavirin và Amantadine ở bệnh nhân viêm gan C mãn tính không đáp ứng với liệu pháp Interferon và Ribavirin

McHutchison JG, Gordon SC, Schiff ER, Shiffman ML, Lee WM, Rustgi VK, Goodman ZD, Ling MH, Cort S, Albrecht JK: Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 339:1485-1492, 1998 Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon SC, Trepo C, Shiffman ML, Zeuzem S, Craxi A, Ling MH, Albrecht J: Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N Engl J Med 339:1493-1499, 1998 Pol S, Couzigou P, Bourliere M, Abergel A, Combis JM, Larrey D, Tran A, Moussalli J, Poupon R, Berthelot P, Brechot C: A randomized trial of ribavirin and interferon-alpha vs. interferon-alpha alone in patients with chronic hepatitis C who were non-responders to a previous treatment. Multicenter Study Group under the coordination of the Necker Hospital, Paris, France. J Hepatol. 31:1-7, 1999 Hoofnagle JH, di Bisceglie AM: The treatment of chronic viral hepatitis. N Engl J Med. 336:347-356, 1997 Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK: Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 358:958-965, 2001 Smith JP: Treatment of chronic hepatitis C with amantadine. Dig Dis Sci 42:1681-1687, 1997 Di Martino V, Boudjema H, Delacour T, Cazier A, Caron C, Coutarel P, Dumouchel P, Cadranel JF: Treatment of chronic hepatitis C with amantadine hydrochloride in patients who had not responded to previous treatment with interferon-alpha and/or ribavirin. Clin Infect Dis 32:830-831, 2001 Yagura M, Harada H: Treatment of chronic hepatitis C patients with amantadine. J Gastroenterol 36:759-763, 2001 Brillanti S, Levantesi F, Masi L, Foli M, Bolondi L: Triple antiviral therapy as a new option for patients with interferon nonresponsive chronic hepatitis C. Hepatology. 32:63-64, 2000 Carlsson T, Lindahl K, Schvarcz R, Wejstal R, Uhnoo I, Shev S, Reichard O: HCV RNA levels during therapy with amantadine in addition to interferon and ribavirin in chronic hepatitis C patients with previous nonresponse or response/relapse to interferon and ribavirin. J Viral Hepat 7:409-413, 2000 Thuluvath PJ, Patt CH, Wu L, Yoo HY, Maygers J, Gelrud L, Anania F, Lobis I, Cox M, Lin J, Black M, Ryan MJ: Doubleblind, randomized, controlled trial of interferon, ribavirin, and amantadine compared to interferon, ribavirin and placebo in the treatment of naïve HCV patients. Gastroenterology 123:73, 2002, (abstract) Thevenot T, Regimbeau C, Ratziu V, Leroy V, Opolon P, Poynard T: Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C in naive patients: 1999 update. J Viral Hepat 8:48-62, 2001 Camma C, Giunta M, Pinzello G, Morabito A, Verderio P, Pagliaro L: Chronic hepatitis C and interferon alpha: conventional and cumulative meta-analyses of randomized controlled trials. Am J Gastroenterol 94:581-595, 1999 Chan J, O'Riordan K, Wiley TE: Amantadine's viral kinetics in chronic hepatitis C infection. Dig Dis Sci 47:438-442, 2002 Torre F, Campo N, Giusto R, Ansaldi F, Icardi GC, Picciotto A: Antiviral activity of amantadine in elderly patients with chronic hepatitis C. Gerontology 47:330-333, 2001 Bacosi M, Russo F, D'innocenzo S, Santolamazza M, Miglioresi L, Ursitti A, De Angelis A, Patrizi F, Ricci GL: Amantadine and interferon in the combined treatment of hepatitis C virus in elderly patients. Hepatol Res 22:231-239, 2002 Gaeta GB, Stornaiuolo G, Stanzione M, Ascione T, Pasquazzi C, Taliani G, Cimino L, Budillon G, Piccinino F: Interferon-alpha plus amantadine in chronic hepatitis C resistant to interferon alone: a pilot randomized study. J Viral Hepat 8:284-286, 2001 Teuber G, Berg T, Naumann U, Raedle J, Brinkmann S, Hopf U, Zeuzem S: Randomized, placebo-controlled, double-blind trial with interferon-alpha with and without amantadine sulphate in primary interferon-alpha nonresponders with chronic hepatitis C. J Viral Hepat 8:276-283, 2001 Younossi ZM, Mullen KD, Zakko W, Hodnick S, Brand E, Barnes DS, Carey WD, McCullough AC, Easley K, Boparai N, Gramlich T: A randomized, double-blind controlled trial of interferon alpha-2b and ribavirin vs. interferon alpha-2b and amantadine for treatment of chronic hepatitis C non-responder to interferon monotherapy. J Hepatol 34:128-133, 2001 Khalili M, Denham C, Perrillo R: Interferon and ribavirin versus interferon and amantadine in interferon nonresponders with chronic hepatitis C. Am J Gastroenterol 95:1284-1289, 2000 Zeuzem S, Teuber G, Naumann U, Berg T, Raedle J, Hartmann S, Hopf U: Randomized, double-blind, placebo-controlled trial of interferon alfa2a with and without amantadine as initial treatment for chronic hepatitis C. Hepatology 32:835-841, 2000 Helbling B, Stamenic I, Viani F, Gonvers JJ, Dufour JF, Reichen J, Cathomas G, Steuerwald M, Borovicka J, Sagmeister M, Renner EL, Investigators of the Swiss Association for the Study of the Liver: Interferon and amantadine in naive chronic hepatitis C: a double-blind, randomized, placebo-controlled trial. Hepatology 35:447-454, 2002 Caronia S, Bassendine MF, Barry R, Mills P, Naoumov NV, Fox R, Lowes J, Hollanders D, Murray-Lyon L, Irving WL, Goldin RD, Foster GR, UK Amantadine Study Group: Interferon plus amantadine versus interferon alone in the treatment of naive patients with chronic hepatitis C: a UK multicentre study. J Hepatol 35:512-516, 2001 Tabone M, Laudi C, Delmastro B, Biglino A, Andreoni M, Chieppa F, Bonardi R, Cariti G, Cusumano S, Brunello F, Calleri G, Manca A, Monica PD, Sidoli L, Rizzetto M, Pera A: Interferon and amantadine in combination as initial treatment for chronic hepatitis C patients. J Hepatol 35:517-521, 2001 Mangia A, Minerva N, Annese M, Leandro G, Villani MR, Santoro R, Carretta V, Bacca D, Giangaspero A, Bisceglia M, Ventrella F, Dell'Erba G, Andriulli A: A randomized trial of amantadine and interferon versus interferon alone as initial treatment for chronic hepatitis C. Hepatology 33:989-993, 2001