Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

American Association for the Advancement of Science (AAAS) - Tập 4 Số 127 - 2012
Janis M. Taube1,2, Robert A. Anders2, Geoffrey D. Young3,4, Haiying Xu1, Rajni Sharma2, Tracee L. McMiller4, Shuming Chen4, Alison P. Klein5,2, Drew M. Pardoll5, Suzanne L. Topalian4, Lieping Chen1,6,5
1Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
3Department of Otolaryngology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
4Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
5Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
6Department of Immunobiology, Yale University, New Haven, CT 06519, USA

Tóm tắt

Activated tumor-infiltrating lymphocytes may induce B7-H1 on melanocytes, which suggests adaptive resistance to antitumor immunity.

Từ khóa


Tài liệu tham khảo

10.1002/1521-4141(200107)31:7<2007::AID-IMMU2007>3.0.CO;2-S

10.1016/j.critrevonc.2010.04.007

10.1038/nri2326

10.1002/j.1460-2075.1992.tb05481.x

10.1038/nm730

10.1038/70932

10.1084/jem.192.7.1027

10.1073/pnas.192461099

10.1200/JCO.2011.38.0899

10.1056/NEJMoa1003466

10.1056/NEJMoa1104621

10.1158/1078-0432.CCR-07-0187

10.1200/JCO.2005.04.5716

10.1126/science.270.5238.985

10.4049/jimmunol.170.3.1257

10.1002/eji.200324228

10.4049/jimmunol.169.10.5538

10.1038/nm863

10.1016/j.immuni.2007.05.016

10.1016/1074-7613(95)90125-6

10.1016/S1074-7613(04)00050-0

10.1126/science.291.5502.319

10.1097/CJI.0b013e31802e085a

10.1016/j.acthis.2006.01.003

10.1158/1078-0432.CCR-04-1469

10.1158/0008-5472.CAN-05-4303

10.1073/pnas.0406351101

10.1593/neo.05733

10.1200/JCO.2009.26.7609

10.1158/1078-0432.CCR-06-1868

10.1126/science.1203486

10.1038/ni1102-991

10.1038/nm1517

10.1002/eji.201040979

10.4049/jimmunol.181.10.6738

10.1158/1078-0432.CCR-09-1652

10.1097/PPO.0b013e3181eacbd8

Ji R. R., Chasalow S. D., Wang L., Hamid O., Schmidt H., Cogswell J., Alaparthy S., Berman D., Jure-Kunkel M., Siemers N. O., Jackson J. R., Shahabi V., An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol. Immunother. 10.1007/s00262-011-1172-6 (2011).

Sznol M., Powderly J. D., Smith D. C., Brahmer J. R., Drake C. G., McDermott D. F., Lawrence D. P., Wolchok J. D., Topalian S. L., Lowy I., Safety and antitumor activity of biweekly MDX-1106 (anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies [abstract 2506]. J. Clin. Oncol. (Meet. Abstr.) 28, 15s (2010).

10.1056/NEJMoa020177

10.1097/00006676-200401000-00023

Eerola A. K., Soini Y., Pääkkö P., A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin. Cancer Res. 6, 1875–1881 (2000).

Schumacher K., Haensch W., Röefzaad C., Schlag P. M., Prognostic significance of activated CD8+ T cell infiltrations within esophageal carcinomas. Cancer Res. 61, 3932–3936 (2001).

10.1056/NEJMoa051424

10.1002/cncr.21951

10.1126/science.1129139

10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5

Mihm M. C., Clemente C. G., Cascinelli N., Tumor infiltrating lymphocytes in lymph node melanoma metastases: A histopathologic prognostic indicator and an expression of local immune response. Lab. Invest. 74, 43–47 (1996).

10.1002/cncr.24899

10.1002/cncr.25747

10.1056/NEJMoa050092

10.1200/JCO.2006.06.2984

10.1200/JCO.2009.23.4799

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 4 Số 127

Thông tin tác giả