Collagen turnover in the adult femoral mid‐shaft: Modeled from anthropogenic radiocarbon tracer measurements

Wiley - Tập 133 Số 2 - Trang 808-816 - 2007
R. E. M. Hedges1, John G. Clement2, C. David L. Thomas2, Tamsin C. O’Connell3,1
1Research Laboratory for Archaeology, University of Oxford, Oxford OX1 3QY, UK
2School of Dental Science, University of Melbourne, Victoria 3010, Australia
3McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, UK

Tóm tắt

AbstractWe have measured the 14C content of human femoral mid‐shaft collagen to determine the dynamics of adult collagen turnover, using the sudden doubling and subsequent slow relaxation of global atmospheric 14C content due to nuclear bomb testing in the 1960s and 1970s as a tracer. 14C measurements were made on bone collagen from 67 individuals of both sexes who died in Australia in 1990‐1993, spanning a range of ages at death from 40 to 97, and these measurements were compared with values predicted by an age‐dependent turnover model. We found that the dataset could constrain models of collagen turnover, with the following outcomes: 1) Collagen turnover rate of females decreases, on average, from 4%/yr to 3%/yr from 20 to 80 years. Male collagen turnover rates average 1.5–3%/yr over the same period. 2) For both sexes the collagen turnover rate during adolescent growth is much higher (5–15%/yr at age 10–15 years), with males having a significantly higher turnover rate than have females, by up to a factor of 2. 3) Much of the variation in residual bomb 14C in a person's bone can be attributed to individual variation in turnover rate, but of no more than about 30% of the average values for adults. 4) Human femoral bone collagen isotopically reflects an individual's diet over a much longer period of time than 10 years, including a substantial portion of collagen synthesised during adolescence Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.

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Wiley

Tập 133 Số 2

808-816

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