Cognitive resilience depends on white matter connectivity: The Maastricht Study

Alzheimer's & Dementia - Tập 19 Số 4 - Trang 1164-1174 - 2023
Nathan R. DeJong1,2,3,4, Jacobus F.A. Jansen5,3,4, Martin P.J. van Boxtel1,3,4, Miranda T. Schram6,7,8,4, Coen D.A. Stehouwer6,8, Pieter C. Dagnelie6,8, Carla Kallen6,8, Abraham A. Kroon6,8, Anke Wesselius9, Annemarie Koster10,11, Walter H. Backes5,3,4, Sebastian Köhler1,2,4
1Alzheimer Centrum Limburg, Maastricht University Medical Center+, Maastricht, the Netherlands
2Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands
3Department of Radiology & Nuclear Medicine Maastricht University Medical Center+ Maastricht The Netherlands
4School for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands
5Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
6Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands
7Maastricht Heart & Vascular Center Maastricht University Medical Center+ Maastricht The Netherlands
8School for Cardiovascular Diseases (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
9School of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
10Department of Social Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
11Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands

Tóm tắt

AbstractIntroduction

Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle‐aged individuals.

Methods

A total of 4759 participants from The Maastricht Study (mean age = 59.2, SD = 8.7, 50.2% male) underwent cognitive testing and diffusion magnetic resonance imaging (dMRI), from which brain volume, structural connectivity, and vascular damage were quantified. Multivariable linear regression was used to investigate whether connectivity modified the association between brain damage and cognition, adjusted for demographic and cardiometabolic risk factors.

Results

More atrophic and vascular brain damage was associated with worse cognition scores. Increasing connectivity moderated the negative association between damage and cognition (χ2 = 8.64, df = 3, p ≤ 0.001); individuals with high damage but strong connectivity showed normal cognition.

Discussion

Findings support the reserve hypothesis by showing that brain connectivity is associated with cognitive resilience.

Từ khóa


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Alzheimer's & Dementia

Tập 19 Số 4

1164-1174

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