Cognitive deficits in the first 24 hours after the onset of first unprovoked generalized Tonic and clonic seizure
Tóm tắt
Background Many people with epilepsy suffer from cognitive deficits as a consequence of their seizure episodes. Relatively few researches have been undertaken to assess the short term impacts of seizure on cognitive function. This study aimed to evaluate changes in cognitive performance in adults with a new onset generalized seizure in the first 24 h after the onset of their attack.
Methods After having given informed consent, 40 patients with first episode of unprovoked generalized tonic-clonic seizure were investigated with a neuropsychological test battery (Wechsler Memory Scale III). Their performance was compared with 40 healthy individuals from the patients' companions.
Results Newly diagnosed patients had significantly worse performance in paired association recall which is a parameter of verbal memory; other memory parameters showed no significant changes after seizure attack.
Conclusion Our data suggested that even with a one-time seizure episode, patients are susceptible to verbal memory impairment.
Tài liệu tham khảo
Hermann, 2007, Epilepsy and cognition, Epilepsy Curr, 7, 1, 10.1111/j.1535-7511.2007.00151.x
Brodie, 1987, Psychomotor impairment and anticonvulsant therapy in adult epileptic patients, Eur J Clin Pharmacol, 31, 655, 10.1007/BF00541291
Smith, 1987, Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin and primidone, Epilepsia, 28, S50, 10.1111/j.1528-1157.1987.tb05778.x
Aikiä, 1995, Verbal learning and memory in newly diagnosed partial epilepsy, Epilepsy Res, 22, 157, 10.1016/0920-1211(95)00042-9
Prevey, 1998, Complex partial and secondarily generalised seizure patients: cognitive functioning prior to treatment with antiepileptic medication. VA Epilepsy Cooperative Study 264 Group, Epilepsy Res, 30, 1, 10.1016/S0920-1211(97)00091-0
Ogunrin, 2000, Cognitive function in Nigerians with newly diagnosed epilepsy, Can J Neurol Sci, 27, 148, 10.1017/S0317167100052264
Pulliainen, 2000, Motor and cognitive functions in newly diagnosed adult seizure patients before antiepileptic medication, Acta Neurol Scand, 101, 73, 10.1034/j.1600-0404.2000.101002073.x
Aikiä, 2001, Verbal memory in newly diagnosed patients and patients with chronic left temporal lobe epilepsy, Epilepsy Behav, 2, 20, 10.1006/ebeh.2000.0140
Helmstaedter, 2005, Impact of newly diagnosed and untreated symptomatic/cryptogenic epilepsy on cognition, Epilepsia, 46, 152
Taylor, 2010, SANAD study group. Patients with epilepsy: cognitively compromised before the start of antiepileptic treatment?, Epilepsia, 51, 48, 10.1111/j.1528-1167.2009.02195.x
Baker, 2011, SANAD group. Newly diagnosed epilepsy, cognitive outcome after 12 month, Epilepsia, 52, 1084, 10.1111/j.1528-1167.2011.03043.x
Marques, 2007, Cognitive decline in temporal lobe epilepsy due to unilateral hippocampal sclerosis, Epilepsy Behav, 10, 477, 10.1016/j.yebeh.2007.02.002
Jokeit, 1999, Long term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross-sectional study, J Neurol Neurosurg Psychiatry, 67, 44, 10.1136/jnnp.67.1.44
Jokeit, 2000, Cognitive impairment in temporal-lobe epilepsy, Lancet, 355, 1018, 10.1016/S0140-6736(05)74765-6
Hermann, 2002, The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function, Epilepsia, 43, 1062, 10.1046/j.1528-1157.2002.49901.x
Oyegbile, 2004, The nature and course of neuropsychological morbidity in chronic temporal lobe epilepsy, Neurology, 62, 1736, 10.1212/01.WNL.0000125186.04867.34
Kent, 2006, The effects of duration of intractable epilepsy on memory function, Epilepsy Behav, 9, 469, 10.1016/j.yebeh.2006.07.005
Helmstaedter, 1999, The phantom of progressive dementia in epilepsy, Lancet, 354, 2133, 10.1016/S0140-6736(99)03542-4
Helmstaedter, 2009, Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?, Brain, 132, 2822, 10.1093/brain/awp182
Orangi, 2002, Standardization of the revised wechsler memory scale in shiraz, IJPCP, 7, 56
Ruhle, 2014, Neuropsychological deficit after a first unprovoked seizure and depressive symptoms in the week before, Epilepsy Behav, 31, 334, 10.1016/j.yebeh.2013.10.007
Marson, 2007, The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial, Lancet, 369, 1000, 10.1016/S0140-6736(07)60460-7
Witt, 2012, Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients, J Neurol, 259, 1727, 10.1007/s00415-012-6526-2
Kalviainen, 1992, Memory and attention in newly diagnosed epileptic seizure disorder, Seizure, 1, 255, 10.1016/1059-1311(92)90034-X
Rösche, 2010, Kognitive defizite und psychiatrische Störungen in frühstadien epileptischer erkrankungen, Fortschr Neurol Psychiatr, 78, 18, 10.1055/s-0028-1109887
Hermann, 2006, Cognitive prognosis in chronic temporal lobe epilepsy, Ann Neurol, 60, 80, 10.1002/ana.20872
Helmstaedter, 2000, Temporal lobe epilepsy: longitudinal clinical, neuropsychological and psychosocial follow-up of surgically and conservatively managed patients, Nervenarzt, 71, 629, 10.1007/s001150050639
Taylor, 2010, Newly diagnosed epilepsy; cognitive outcome at five years, Epilepsy Behav, 18, 397, 10.1016/j.yebeh.2010.05.007
Holmes, 1998, Is partial epilepsy progressive? Ten-year follow-up of EEG and neuropsychological changes in adults with partial seizures, Epilepsia, 39, 1189, 10.1111/j.1528-1157.1998.tb01310.x
Seidenberg, 1981, Changes in seizure frequency and test-retest scores on the Wechsler Adult Intelligence Scale, Epilepsia, 22, 75, 10.1111/j.1528-1157.1981.tb04334.x
Dodrill, 1992, Neuropsychological abilities before and after 5 years of stable antiepileptic drug therapy, Epilepsia, 32, 327, 10.1111/j.1528-1157.1992.tb02323.x
Dodrill, 2002, Progressive cognitive decline in adolescents and adults with epilepsy, Prog Brain Res, 135, 399, 10.1016/S0079-6123(02)35037-4
Selwa, 1994, Serial cognitive testing in temporal lobe epilepsy: longitudinal changes with medical and surgical therapies, Epilepsia, 35, 743, 10.1111/j.1528-1157.1994.tb02505.x
Zeman, 2009, When a patient with epilepsy complains about poor memory, Pract Neurol, 9, 85, 10.1136/jnnp.2009.172205
Eddy, 2011, The cognitive impact of antiepileptic drugs, Ther Adv Neural Disord, 4, 385, 10.1177/1756285611417920