Clinicopathological and immunohistochemical features of three pilomyxoid astrocytomas: Comparative study with 11 pilocytic astrocytomas

Pathology International - Tập 59 Số 2 - Trang 80-85 - 2009
Vishwa Jeet Amatya1, Ryota Akazawa2, Yoji Sumimoto2, Yukio Takeshima2, Kouki Inai2
1Department of Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
2Department of Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

Tóm tắt

Pilomyxoid astrocytoma, first described by Tihan et al., was recently included as an established variant of pilocytic astrocytoma in the World Health Organization classification of CNS tumors. Histologically, it much resembles pilocytic astrocytoma, but monomorphic myxoid tumor of pilocytic cells with prominent angiocentric growth pattern without Rosenthal fibers or eosinophilic granular bodies is characteristic of pilomyxoid astrocytoma. Pilomyxoid astrocytoma is thought to be more aggressive with more frequent local recurrence as well as cerebrospinal spread. The authors recently encountered a case of pilomyxoid astrocytoma, therefore the purpose of the present study was undertake a retrospective review of pilocytic astrocytomas previously diagnosed during the past 10 years. Consequently, two of them were found to have histological features suggestive of pilomyxoid astrocytoma and both involved multiple recurrence, suggesting aggressive behavior in comparison to pilocytic astrocytoma. Therefore, knowledge of this entity is essential to surgical pathologists and clinicians for patient management.

Từ khóa


Tài liệu tham khảo

10.1097/00005072-199910000-00004

Janisch W, 1985, Diencephalic pilocytic astrocytoma with clinical onset in infancy. Biological behavior and pathomorphological findings in 11 children, Zentralbl Allg Pathol, 130, 31

10.1097/00005072-199605000-00204

10.1007/s00401-004-0858-7

Fuller CE, 2001, Suprasellar monomorphous pilomyxoid neoplasm: An ultastructural analysis, Clin Neuropathol, 20, 256

10.3171/jns.2003.99.2.0416

10.1227/01.NEU.0000097266.89676.25

10.1227/01.NEU.0000146212.95421.B3

10.3171/foc.2005.18.6.8

10.1111/j.1440-1789.2006.00641.x

Burger PC, 2007, WHO Classification of Tumours of the Nervous System, 20, 10.55418/9781933477015

10.1111/j.1750-3639.2007.00082.x

10.1007/s11060-006-9151-z

10.1227/01.NEU.0000079330.01541.6E

10.1016/S0002-9440(10)63730-3

10.1093/jnen/63.5.499

10.1111/j.1440-1789.2008.00896.x

10.1046/j.1365-2559.2000.01005.x

10.1007/s11060-006-9216-z

10.1097/00005072-199901000-00006

Thông tin
Thông tin xuất bản

Pathology International

Tập 59 Số 2

80-85

Thông tin tác giả