Clinical significance of serum hyaluronan in chronic fibrotic interstitial pneumonia

Respirology - Tập 18 Số 8 - Trang 1236-1243 - 2013
Yayoi Inokoshi1, Yoshinori Tanino1, Xintao Wang1, Suguru Sato1, Naoko Fukuhara1, Takefumi Nikaido1, Atsuro Fukuhara1, Junpei Saito1, Charles W. Frevert2, Mitsuru Munakata1
1Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan
2Center for Lung Biology University of Washington School of Medicine Seattle Washington USA

Tóm tắt

AbstractBackground and objectiveHyaluronan is an important constituent of the extracellular matrix in lungs, and growing evidence demonstrates its important biological properties in the lung. However, its role in interstitial pneumonia remains to be fully clarified. The goal of this study was to clarify the role of hyaluronan in interstitial pneumonia.MethodsHyaluronan in serum and bronchoalveolar lavage (BAL) fluid of chronic interstitial pneumonia (CIP) patients was measured, and the correlation with clinical parameters was determined. In addition, the correlation between hyaluronan in serum and clinical parameters was analysed in patients with acute exacerbation of interstitial pneumonia (IP‐AE).ResultsWhen compared with healthy controls, serum hyaluronan was significantly greater in patients with CIP and was positively correlated with serum biomarkers of inflammation and fibrosis, such as C‐reactive protein and surfactant protein‐D. In BAL fluid, the amount of hyaluronan was positively correlated with the percentage of inflammatory cells and the amount of CXCL8. When compared with CIP patients, patients with IP‐AE had significantly greater amounts of serum hyaluronan, and patients with the highest serum hyaluronan had the worst 60‐day outcomes.ConclusionsThis work suggests that serum hyaluronan may be a clinically useful biomarker of interstitial pneumonia and suggests the possibility that hyaluronan is involved in the pathogenesis of interstitial pneumonia by recruiting inflammatory cells into the lungs.

Từ khóa


Tài liệu tham khảo

10.1165/ajrcmb.20.1.2941

10.4049/jimmunol.168.12.6470

10.1038/nm1315

Milman N, 1995, Hyaluronan and procollagen type III aminoterminal peptide in serum and bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis, Sarcoidosis, 12, 38

10.1136/thx.44.2.126

10.1183/09031936.02.00492002

10.1164/rccm.200703-463PP

10.1164/ajrccm.161.2.ats3-00

10.1378/chest.07-0323

10.4049/jimmunol.0903274

10.1164/rccm.200803-386OC

10.1165/rcmb.2011-0294OC

10.1002/ar.21094

Allen SJ, 1991, Lung hyaluronan during development: a quantitative and morphological study, Am. J. Physiol., 260, 1449

10.1126/science.1069659

10.1164/ajrccm.154.6.8970376

10.1046/j.1440-1843.1999.00164.x

10.1084/jem.20102510

10.1378/chest.08-2209

10.1183/09031936.02.00081102

Kohno N, 1999, Serum marker KL‐6/MUC1 for the diagnosis and management of interstitial pneumonitis, J. Med. Invest., 46, 151

10.1309/UVARMDY8FE9FJDKU

10.1183/09031936.03.00022703

10.1042/bj2580919

10.1074/jbc.274.35.25085

10.1096/fasebj.6.7.1563592

10.1186/1476-9255-5-20

10.1056/NEJMoa042976

10.1073/pnas.0813368106

10.1016/S0945-053X(01)00170-6

10.1378/chest.07-1948

10.1164/ajrccm.154.2.8756813

10.7326/0003-4819-132-12-200006200-00004

10.1097/01.pas.0000213341.70852.9d

10.1183/09031936.06.00114004

10.1164/rccm.201206-1109OC

10.1164/rccm.2009-040GL

Thông tin
Thông tin xuất bản

Respirology

Tập 18 Số 8

1236-1243

Thông tin tác giả