Clinical characteristics of 3062 COVID‐19 patients: A meta‐analysis

Journal of Medical Virology - Tập 92 Số 10 - Trang 1902-1914 - 2020
Jieyun Zhu1, Pan Ji1, Jielong Pang1, Zhimei Zhong1, Hongyuan Li1, Cuiying He1, Jianfeng Zhang1, Chunling Zhao1
1Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China

Tóm tắt

AbstractWe aimed to systematically review the clinical characteristics of coronavirus disease 2019 (COVID‐19). Seven databases were searched to collect studies about the clinical characteristics of COVID‐19 from January 1, 2020 to February 28, 2020. Then, meta‐analysis was performed by using Stata12.0 software. A total of 38 studies involving 3062 COVID‐19 patients were included. Meta‐analysis showed that a higher proportion of infected patients was male (56.9%). The incidence rate of respiratory failure or acute respiratory distress syndrome was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%), and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia (13.1%), shivering (10.9%), and abdominal pain (4.4%). The proportion of patients that was asymptomatic was 11.9%. Normal leukocyte counts (69.7%), lymphopenia (56.5%), elevated C‐reactive protein levels (73.6%), elevated ESR (65.6%), and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients were found with elevated D‐dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%), and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving a single lung and 75.7% of patients had lesions involving bilateral lungs. The most commonly experienced symptoms of COVID‐19 patients were fever, fatigue, cough, and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C‐reactive protein and ESR. Bilateral lung involvement was common.

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Tài liệu tham khảo

10.1007/s11427-020-1637-5

WHO.Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance [Internet].2020.https://www.who.int/internalpublicationsdetail/clinicalmanagementofsevereacuterespiratoryinfectionwhennovelcoronavirus(ncov)infectionissuspected. Accessed April 7 2020.

WHO.Statement on the second meeting of the International Health Regulations;2005.Emergency Committee regarding the outbreak of novel coronavirus (2019‐nCoV)[Internet].https://www.who.int/newsroom/detail/30-01-2020-statement-on-thesecond-meeting-of-the-international-healthregulations-(2005)-emergency-committeeregarding-the-outbreak-of-novel-coronavirus-(2019-ncov). Accessed April 7 2020.

WHO.WHO Director‐General's remarks at the media briefing on 2019‐nCoV on 11 February2020[Internet].https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. Accessed April 7 2020.

WHO.WHO Director‐General's opening remarks at the media briefing on COVID‐19–11 March2020[Internet].https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19-11-march-2020. Accessed April 7 2020.

WHO.Coronavirus disease 2019 (COVID‐19) outbrake situation[Internet].https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed April 7 2020.

Zhang MQ, 2020, Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing, Chin J Tuberc Respir Dis, 215

10.1002/jmv.25735

Li L, 2020, 2019 novel coronavirus patients' clinical characteristics, discharge rate and fatality rate of meta‐analysis, J Med Virol, jmv.25757

Cheng KB, 2020, Clinical characteristics of 463 patients with common and severe type coronavirus disease 2019, Shanghai Med J, 1

Sun WW, 2020, Epidemiological characteristics of 2019 novel coronavirus family clustering in Zhejiang province, Chin J Prev Med, 54

NICE.Appendix 4 Quality of case series form [Internet].https://www.nice.org.uk/guidance/cg3/documents/appendix-4-quality-of-case-series-form2. Accessed April 7 2020.

Chen L, 2020, Clinical diagnosis and treatment of critical patients with novel coronavirus pneumonia (report of 12 cases), Chin J Clin Med, 27, 32

Fang XW, 2020, Clinical characteristics and treatment analysis of 79 cases of COVID‐19, Chin Pharmacol Bull

Yu SM, 2020, Analysis of the relationship between clinical features and tongue manifestations of 40 cases with novel coronavirus pneumonia, Beijing J Tradit Chin Med

Zhang X, 2020, A preliminary study on the clinical characteristics and Chinese medical syndrome of 42 cases of COVID‐19 in Nanjing, J Nanjing Univ Trad Chin Med

Liu M, 2020, Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia, Chin J Tuberculos Respirat Dis

Li YY, 2020, Comparison of the clinical characteristics between RNA positive and negative patients clinically diagnosed with 2019 novel coronaviruspneumonia, Chin J Tuberculos Respirat Dis

Xiao KF, 2020, The clinical features of the 143 patients with COVID‐19 in North‐East of Chongqing, J Third Mil Med Univ

Sun HY, 2020, A preliminary study on TCM syndrome characteristics of 88 patients with COVID‐19 in Tianjin, J Tradit Chin Med

Xu B, Analysis of traditional Chinese medicine syndromes of 46 cases of COVID‐19, Chin J Exp Tradit Med Formulae

Zhuang YJ, Clinical and epidemiological characteristics of 26 patients diagnosed with novel coronavirus pneumonia, Chin J Nosocomiol

Lu Y, 2019, Analysis on Chinese medical clinical characteristics of 50 patients with 2019‐nCoV‐infected pneumonia, Acad J Shanghai Univ Tradit Chin Med, 14

10.1136/bmj.m606

Zhang JJ, Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China, Allergy

WangD HuB HuC et al.Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus‐infected pneumonia in Wuhan China.JAMA.2020.https://www-ncbi-nlm-nih-gov.library.westernwyoming.edu/pubmed/?term=32031570. Accessed March 5 2020.

Kui L, 2020, Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei province, Chin Med J, 133, 1061

10.1016/S0140-6736(20)30183-5

10.1016/S0140-6736(20)30211-7

10.1056/NEJMoa2002032

Li J, Epidemiological and clinical characteristics of 17 hospitalized patients with 2019 novel coronavirus infections outside Wuhan, China, MedRxiv

10.1001/jama.2020.1623

10.1148/radiol.2020200463

10.1148/radiol.2020200230

Feng K, 2020, Analysis of CT features of 15 children with 2019 novel coronavirus infection, Chin J Pediatr

Wang JC, 2020, Dynamic changes of chest CT imaging in patients with corona virus disease‐19 (COVID‐19), J Zhejiang Univ Med Sci

Wu J, Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features, Invest Radiol

Huang XQ, 2020, Analysis of Chinese medical characteristics of 35 patients with novel coronavirus pneumonia, J Emerg Tradit Chin Med

Cao J, Clinical characteristics and CT signs of corona virus disease 2019 (COVID‐19) in the elderly, Med J Wuhan Univ

Liao XN, 2020, Chest CT features comparison between COVID⁃19 and bacterial pneumonia, Med J Wuhan Univ

Yu XT, 2020, Chest CT features of COVID‐19, J Pract Med

Li XH, 2020, Clinical presentations and CT features of imported corona virus disease 2019, Chin J Med Imaging Technol

LiuFM DingHL GongXM et al.Chest CT performance and clinical characteristics of coronavirus disease 2019 (COVID‐19).Radiologic Practice.https://doi.org/10.13609/j.cnki.1000-0313.2020.03.001. Accessed March 5 2020.

Wang K, CT characteristic appearances of patients with novel coronavirus pneumonia, Chin J Clin Med

Cheng DZ, 2020, Clinical effectiveness and case analysis in 54 NCP patients treated with lanhua qingwen granules, World Chin Med

Liu YX, 2020, Clinical and biochemical indicators related to lung injury in patients with 2019‐nCoV infection, Scientia Sinica

Zhong FY, 2020, CT findings in 2019 novel coronavirus disease (COVID‐19) patients, Med J Wuhan Univ

Gao L, 2020, CT features of patients with imported 2019‐nCov‐pneumonia, J Xi'an Jiaotong Univ Med Sci

Wang T, 2020, Clinical efficacy analysis of 50 cases of corona virus disease 2019 in traditional Chinese medicine, Jilin J Chin Med

Chem L, Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia, Chin J Tuberc Respir Dis

Su S, 2020, Advances in research on SARS‐CoV‐2, J Xi'an Jiaotong Univ Med Sci

10.1056/NEJMp2000929

10.1016/j.idc.2019.07.001

10.1016/j.idc.2019.08.001

Special expert group for control of the epidemic of novel coronavirus pneumonia of the Chinese Preventive Medicine Association, 2020, An update on the epidemiological charac teristics of novel coronavirus pneumonia COVID‐19, Zhonghua liu xing bingxue za zhi, 41, 139

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Journal of Medical Virology

Tập 92 Số 10

1902-1914

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