Clinical association between non‐alcoholic fatty liver disease and the development of hypertension

Journal of Gastroenterology and Hepatology (Australia) - Tập 29 Số 11 - Trang 1926-1931 - 2014
Jae‐Hong Ryoo1, Young Ju Suh2, Ho Cheol Shin3, Yong Kyun Cho4, Joong‐Myung Choi1, Sung Keun Park1,5
1Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea
2Institute of Clinical Research School of Medicine Inha University Incheon Korea
3Department of Family Medicine Kangbuk Samsung Hospital School of Medicine Sungkyunkwan University Seoul Korea
4Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University Seoul Korea
5Total Healthcare Center Kangbuk Samsung Hospital School of Medicine Sungkyunkwan University Seoul Korea

Tóm tắt

AbstractBackground and AimNon‐alcoholic fatty liver disease (NAFLD) is getting an increasing attention for its clinical implications on cardiovascular disease (CVD). However, epidemiologic data are not so evident to sustain the causative association between NAFLD and hypertension, the major cause of CVD. Accordingly, we designed this study to investigate the clinical association between NAFLD and the development of hypertension.MethodsTo assess the natural course of blood pressure according to degree of NAFLD (normal, mild, and moderate to severe), we conducted a prospective cohort study on the 22 090 Korean men without hypertension for 5 years. We serially checked the various metabolic factors including systolic and diastolic blood pressure in order to monitor the development of hypertension.ResultsThe incidence rate of hypertension increased according to the degree of NAFLD (normal: 14.4%, mild: 21.8%, moderate to severe: 30.1%, P < 0.001). Even after adjusting for other multiple covariates, the hazard ratios (95% confidence intervals) for hypertension were higher in the mild group (1.07; 1.00–1.15) and moderate to severe group (1.14; 1.00–1.30), compared with normal group, respectively (P for trend < 0.001).ConclusionDevelopment of hypertension is more potentially associated with the more progressive NAFLD than normal or milder state. In addition, NAFLD was an independent risk factor for hypertension.

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Journal of Gastroenterology and Hepatology (Australia)

Tập 29 Số 11

1926-1931

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