Dược Lý Lâm Sàng và Quản Lý Của Các Thuốc Platinum Đã Được Thiết Lập

Drugs - Tập 59 - Trang 19-27 - 2012
Peter J. O'Dwyer1, James P. Stevenson1, Steven W. Johnson1
1University of Pennsylvania Cancer Center, Philadelphia, USA

Tóm tắt

Chúng tôi đánh giá về dược lý và quản lý lâm sàng của các thuốc chống ung thư dựa trên platinum thường được sử dụng như cisplatin và carboplatin, cũng như oxaliplatin dựa trên diamminocyclohexane đã được phê duyệt gần đây. Việc phát triển các dẫn xuất của cisplatin đã tập trung vào việc xác định các hợp chất có độc tính thấp hơn và có phổ hoạt động khác biệt. Carboplatin là một ví dụ cho điều này, trong khi dữ liệu ban đầu với oxaliplatin hỗ trợ cho hoạt động của nó trên các khối u kháng cisplatin. Dược động học lâm sàng của các loại thuốc này cũng được đánh giá. Việc tích hợp các dữ liệu này vào thiết kế các phác đồ lâm sàng đã cho phép liệu pháp cá nhân hóa với carboplatin và tăng cường độ an toàn. Nghiên cứu thêm về dược lực học của tất cả các tác nhân này được kỳ vọng sẽ dẫn đến ứng dụng chọn lọc của chúng. Các hiệu quả lâm sàng của các dẫn xuất này cũng được thảo luận.

Từ khóa

#cisplatin #carboplatin #oxaliplatin #dược lý #dược động học #khối u kháng

Tài liệu tham khảo

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