Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

American Association for the Advancement of Science (AAAS) - Tập 248 Số 4959 - Trang 1122-1124 - 1990
Frederick Esch1, Pamela S. Keim1, Eric C. Beattie1, Russell Blacher1, Alan R. Culwell1, Tilman Oltersdorf1, D B McClure2, Pamela J. Ward1
1Athena Neurosciences, Incorporated, South San Francisco, CA 94080.
2Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.

Tóm tắt

The amyloid β peptide (AβP) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant AβP deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the AβP, thus preventing AβP deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.

Từ khóa


Tài liệu tham khảo

ESCH F.S. unpublished data.

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