Circulating steroids negatively correlate with tinnitus

Daniell, 1998, Occupational hearing loss in Washington state, 1984–1991: II. Morbidity and associated costs, Am. J. Ind. Med., 33, 529, 10.1002/(SICI)1097-0274(199806)33:6<529::AID-AJIM2>3.0.CO;2-L Daniell, 2002, Increased reporting of occupational hearing loss: workers’ compensation in Washington State, 1984–1998, Am. J. Ind. Med., 42, 502, 10.1002/ajim.10146 Shargorodsky, 2010, Prevalence and characteristics of tinnitus among US adults, Am. J. Med., 123, 711, 10.1016/j.amjmed.2010.02.015 Coelho, 2007, Tinnitus in children and associated risk factors, Prog. Brain Res., 166, 179, 10.1016/S0079-6123(07)66016-6 Semaan, 2010, Contemporary perspectives on the pathophysiology of Meniere’s disease: implications for treatment, Curr. Opin. Otolaryngol. Head Neck Surg., 18, 392, 10.1097/MOO.0b013e32833d3164 Sulcova, 1997, Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects, J. Endocrinol., 154, 57, 10.1677/joe.0.1540057 Havlikova, 2002, Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects, J. Clin. Endocrinol. Metab., 87, 2225, 10.1210/jcem.87.5.8499 Baulieu, E.E., et al., Steroid Hormone Regulation of the Brain. Pergamon Press ed. Oxford, Wenner-Green Center International Symposium Series. vol. 34, 1981. 3–14. Kancheva, 2011, Neuroactive steroids in periphery and cerebrospinal fluid, Neuroscience, 191, 22, 10.1016/j.neuroscience.2011.05.054 Mensah-Nyagan, 1999, Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system, Pharmacol. Rev., 51, 63 Morfin, 2001, Neurosteroid 7-hydroxylation products in the brain, Int. Rev. Neurobiol., 46, 79, 10.1016/S0074-7742(01)46059-4 Kriz, 2008, Steroid sulfatase and sulfuryl transferase activities in human brain tumors, J. Steroid Biochem. Mol. Biol., 109, 31, 10.1016/j.jsbmb.2007.12.004 Kriz, 2005, Steroid sulfatase and sulfuryl transferase activity in monkey brain tissue, Steroids, 70, 960, 10.1016/j.steroids.2005.07.005 Ghosh, 2011, Cellular localization and functional significance of CYP3A4 in the human epileptic brain, Epilepsia, 52, 562, 10.1111/j.1528-1167.2010.02956.x Stevens, 2003, Developmental expression of the major human hepatic CYP3A enzymes, J. Pharmacol. Exp. Ther., 307, 573, 10.1124/jpet.103.054841 Miller, 2004, Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450, Drug Metab. Dispos., 32, 305, 10.1124/dmd.32.3.305 Reddy, 2003, Pharmacology of endogenous neuroactive steroids, Crit. Rev. Neurobiol., 15, 197, 10.1615/CritRevNeurobiol.v15.i34.20 Vyklicky, 2015, Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule, Sci. Rep., 5, 10935, 10.1038/srep10935 Sun, 2007, Neurotransmitter modulation relates with tinnitus signal generation and management, J. Otol., 2, 2 Marx, 2006, Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?, Pharmacol. Biochem. Behav., 84, 598, 10.1016/j.pbb.2006.07.026 Kancheva, 2010, Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances, J. Steroid Biochem. Mol. Biol., 119, 35, 10.1016/j.jsbmb.2009.12.006 Naylor, 2008, Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer’s disease, and related to neuropathological disease stage, J. Clin. Endocrinol. Metab., 93, 3173, 10.1210/jc.2007-1229 Trygg, 2007, Chemometrics in metabonomics, J. Proteome Res., 6, 469, 10.1021/pr060594q Trygg, 2002, Orthogonal projections to latent structure, J. Chemom., 16, 119, 10.1002/cem.695 Madsen, 2010, Chemometrics in metabolomics–a review in human disease diagnosis, Anal. Chim. Acta, 659, 23, 10.1016/j.aca.2009.11.042 Czech, 2012, Metabolite profiling of Alzheimer’s disease cerebrospinal fluid, PLoS ONE, 7, e31501, 10.1371/journal.pone.0031501 Parizek, 2016, A comprehensive evaluation of steroid metabolism in women with intrahepatic cholestasis of pregnancy, PLoS ONE, 11, e0159203, 10.1371/journal.pone.0159203 Hill, 2010, Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor, J. Steroid Biochem. Mol. Biol., 121, 594, 10.1016/j.jsbmb.2009.10.012 Hill, 2010, Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy, J. Steroid Biochem. Mol. Biol., 122, 239, 10.1016/j.jsbmb.2010.06.003 Hill, 2011, The steroid metabolome in lamotrigine-treated women with epilepsy, Steroids, 76, 1351, 10.1016/j.steroids.2011.07.002 Dehennin, 1996, Plasma and urinary markers of oral testosterone misuse by healthy men in presence of masking epitestosterone administration, Int. J. Sports Med., 17, 315, 10.1055/s-2007-972853 Brochu, 1987, Comparative study of plasma steroid and steroid glucuronide levels in normal men and in men with benign prostatic hyperplasia, Prostate, 11, 33, 10.1002/pros.2990110105 Sanchez-Guijo, 2015, Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS, J. Lipid Res., 56, 1843, 10.1194/jlr.D061499 Labrie, 1997, Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging, J. Clin. Endocrinol. Metab., 82, 2396, 10.1210/jcem.82.8.4160 Brochu, 1987, Effects of flutamide and aminoglutethimide on plasma 5 alpha-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate, J. Steroid Biochem., 28, 619, 10.1016/0022-4731(87)90388-8 Tokushige, 2013, Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease, J. Gastroenterol., 48, 1392, 10.1007/s00535-013-0766-5 Meng, 1997, Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy, Hepatology, 26, 1573, 10.1002/hep.510260627 Abu-Hayyeh, 2013, Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype, Hepatology, 57, 716, 10.1002/hep.26055 Guennoun, 2015, Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection, J. Steroid Biochem. Mol. Biol., 146, 48, 10.1016/j.jsbmb.2014.09.001 Melcangi, 2014, Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions, Prog. Neurobiol., 113, 56, 10.1016/j.pneurobio.2013.07.006 Sakata, 1997, Clinical experiences of steroid targeting therapy to inner ear for control of tinnitus, Int. Tinnitus J., 3, 117 Schuld, 2000, Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers, J. Clin. Endocrinol. Metab., 85, 4624 Auci, 2009, 7-Hydroxy androstene steroids and a novel synthetic analogue with reduced side effects as a potential agent to treat autoimmune diseases, Autoimmun. Rev., 8, 369, 10.1016/j.autrev.2008.11.011 Hennebert, 2007, Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes, J. Steroid Biochem. Mol. Biol., 104, 326, 10.1016/j.jsbmb.2007.03.026 Kim, 2014, Diagnostic value and clinical significance of stress hormones in patients with tinnitus, Eur. Arch. Otorhinolaryngol., 271, 2915, 10.1007/s00405-013-2785-5 Baldo, 2012, Antidepressants for patients with tinnitus, Cochrane Database Syst. Rev., CD003853 Syka, 2000, Threshold shifts and enhancement of cortical evoked responses after noise exposure in rats, Hear. Res., 139, 59, 10.1016/S0378-5955(99)00175-6 Sripada, 2014, The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity, Hum. Brain Mapp., 35, 3249, 10.1002/hbm.22399