Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells

Blood Advances - Tập 4 - Trang 87-99 - 2020
Karen Phaik Har Lim1,2,3, Paul Milne4, Michael Poidinger5, Kaibo Duan5, Howard Lin1,2, Naomi McGovern6, Harshal Abhyankar1,2, Daniel Zinn1,2, Thomas M. Burke1,2,3,7, Olive S. Eckstein1,2, Rikhia Chakraborty1,2, Amel Sengal1,2, Brooks Scull1,2, Evan Newell5, Miriam Merad8, Kenneth L. McClain1,2, Tsz-Kwong Man1,2, Florent Ginhoux5, Matthew Collin4, Carl E. Allen1,2,3
1Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX
2Division of Pediatric Hematology-Oncology, Department of Pediatrics, College of Medicine, Baylor University, Houston, TX;
3Graduate Program in Translational Biology and Molecular Medicine, College of Medicine, Baylor University, Houston, TX;
4Human Dendritic Cell Laboratory, Newcastle University, Newcastle upon Tyne, United Kingdom;
5Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore
6Department of Pathology, University of Cambridge, Cambridge, United Kingdom
7Medical Scientist Training Program, College of Medicine, Baylor University, Houston, TX
8Icahn School of Medicine at Mount Sinai, New York, NY

Tóm tắt

Key PointsTranscriptional profile of LCH CD1a+CD207+ DCs is most closely related to that of CD1c+ mDCs in the blood. Lineage tracing with BRAFV600E and HLA-DQB2 expression supports CD1c+ mDCs as precursors to LCH CD1a+CD207+ DCs.

Tài liệu tham khảo

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