Circular RNAs: diversity of form and function
Tóm tắt
It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to an upstream 3′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in
Từ khóa
Tài liệu tham khảo
2013, Hepatitis δ virus: a peculiar virus, Adv Virol, 2013, 560105
2014, miRNA sponges: soaking up miRNAs for regulation of gene expression, Wiley Interdiscip Rev RNA, 5, 317, 10.1002/wrna.1213
1992, Splicing with inverted order of exons occurs proximal to large introns, EMBO J, 11, 1095, 10.1002/j.1460-2075.1992.tb05148.x
1996, Exon circularization in mammalian nuclear extracts, RNA, 2, 603
2014, Circularly permuted tRNA genes: their expression and implications for their physiological relevance and development, Front Genet, 5, 63
2002, The group I-like ribozyme DiGIR1 mediates alternative processing of pre-rRNA transcripts in Didymium iridis, Eur J Biochem, 269, 5804, 10.1046/j.1432-1033.2002.03283.x
1997, Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis, Mol Cell Biol, 17, 2985, 10.1128/MCB.17.6.2985
2014, Complementary sequence-mediated exon circularization, Cell, 99, 99